Carnitine: A Neuromodulator in Aged Rats

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 58, Issue 11, 2003, Pages 970-974

  Juliet, Packiasamy A R ^a   Balasubramaniam, Deepak ^b   Balasubramaniam, Naveen ^b   Panneerselvam, Chinnakannu ^c  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b MADRAS MEDICAL COLLEGE   (India)

^c UNIVERSITY OF MADRAS   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CARNITINE; DOPAMINE; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; BRAIN CORTEX; BRAIN NERVE CELL; BRAIN REGION; CHOLINERGIC NERVE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFECT; DRUG RESPONSE; EXPERIMENT; HIPPOCAMPUS; MALE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SENESCENCE;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0345016320     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/58.11.b970     Document Type: Article

References (39)

1. Timiras PS. Oxidative stress and loss of receptor sensitivity in aging. In: Timiras PS, Quay WD, Vernadakis A, eds. Hormones and Aging. Boca Raton, FL: CRC Press; 1995:3-22.
2. Enna SJ, Samirajski T, Beer B, eds. Brain Neurotransmitters and Receptors in Aging and Age-Related Disorders. New York: Raven Press; 1987.
3. Evans PH. Free radicals in brain metabolism and pathology. Br Med Bull. 1993;49:577-587.
4. Gerlach M, Ben-Shachar D, Riederer P. Altered brain metabolism of iron as a cause of neurodegenerative diseases? J Neurochem. 1994;63:793-807.
5. Urabe K, Aroca P, Tsukamoto K. The inherent cytotoxicity of melanin precursors: a revision. Biochem Biophys Acta. 1994;1221:272-278.
6. Kish SJ, Shannak K, Rajput A, Deck JHN, Hornykiewicz O. Aging produces a specific pattern of striatal dopamine loss-implications for the etiology of idiopathic Parkinson's disease. J Neurochem. 1992;58:642-648.
7. Berman SB, Zigmond NJ, Hastings TG. Modification of dopamine transporter function: effect of reactive oxygen species and dopamine. J Neurochem. 1996;67:593-600.
8. + and adenosine triphosphate in isolated brain synaptosomes. J General Physiol. 1990;95:591-616.
9. Orrinus S, Nicotera P. The calcium ion and cell death. J Neural Trans 1994;43(Suppl.):1-11.
10. Nalecz KA, Nalecz MJ. Carnitine - a known compound a novel function in neural cells. Acta Neurobiol Exper. 1996;56:597-609.
11. Angelucci, Ramacci MT, Taglilatela G, et al. Nerve growth factor binding in aged rat central nervous system: effect of acetyl-L-carnitine. J Neurosci Res. 1988;20:491-496.
12. Kalaiselvi CJ, Panneerselvam C. Effect of L-carnitine on the status of lipid peroxidation and antioxidants in aging rats. J Nutr Biochem 1998;9:575-578.
13. Paulson DJ, Schmidt MJ, Traxler JS, Ramacci MT, Shug AL. Improvement of myocardial function in diabetic rats after treatment with L-carnitine. Metabol. 1984;33:358-363.
14. Dayanandan A, Kumar P, Kalaiselvi T, Panneerselvam C. Effect of L-carnitine on blood lipid composition in athrosclerotic rat. J Clin Biochem Nutr. 1994;17:81-89.
15. 3H] DOPA in various regions of rat brain. J Neurochem. 1966;13:655-699.
16. Pearson DJ, Tubbs PK, Chase FA. Carnitine and acyl carnitines. In: Bergmeyer HV, ed. Methods in Enzymatic Analysis. New York: Academic Press; 1974:1762-1769.
17. Kari HP, Davision PP, Kohl HH, Kochar MM. Effects of ketamine on brain monoamine levels in rats. Res Commun Chem Pathol Physiol. 1978;20:175-185.
18. Piovesan P, Pacifici L, Taglialatela G, Ramacci MT, Angelucci L. L-Acetyl-L-carnitine treatment increase choline acetyltransferase activity and NGF levels in the CNS of adult rats following total fimbria-fomix transection. Brain Res. 1994;633:77-82.
19. Ponzio F, Calderini G, Lomuscio G, Vantini G, Taffano G, Algeri S. Changes in monoamines and their metabolite levels in some brain regions of aged rats. Neurobiol Aging. 1982;3:23-29.
20. Rajalakshmi R, Thrivikraman V, Ramakrishnan CV. Protein deficiency and regional chemistry of the brain: part I - effects of protein deficiency on regional distribution of protein, glutathione and ascorbic acid in rat brain. Ind J Biochem Biophys. 1971;8:295-299.
21. Shug AL, Schmidt MJ, Golden GT, Fariello RG. The distribution of carnitine in the mammalian brain. Life Sci. 1982;31:2869-2874.
22. Costell M, O'Connor JE, Grisolis S. Age-dependent decrease of carnitine content in muscle of mice and humans. Biochem Biophy Res Commun. 1989;161:1135-1143.
23. 6 requirement of elderly men and women. J Nutr. 1991;12:1062-1074.
24. 6 deficiency and aging on pyridoxal 5′-phosphate levels and glycogen phosphorylase activity in rats. J Nutr Biochem. 1991;2:135-141.
25. Morley JE. Nutritional status of the elderly. Am J Med. 1986;81:679-695.
26. Maccari F, Arseni A, Chiodi P.M, Ramacci T, Angelucci L. Levels of carnitine in brain and other tissues of rats of different aged: effect of acetyl-L-carnitine administration. Exp Gerontol. 1990;35:127-134.
27. Fornstedt B, Pileblad E, Carlsson A. In vivo autooxidation of dopamine in guinea pig striatum increases with age. J Neurochem. 1990;55:655-659.
28. Chiueh CC, Miyake H, Peng MT. Role of dopamine autooxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced Parkinsonism. In: Narabayashi H, Nagatsu N, Yanagisawa T, Mizuno Y, eds. Advances in Neurobiology. New York: Raven Press; 1993:251-256.
29. Jenner P, Dexter DT, Schapira AHV, Marsden CD. Free radical involvement and altered iron metabolism as a cause of Parkinson's disease. In: Narsden CD, Fahns, eds. The Assessment and Therapy of Parkinsonism. Lancashire, England: The Parthenon Publishing Group; 1990:17-30.
30. Juliet Arockia Rani P, Panneerselvam C. Carnitine as a free radical scavenger in aged rats. Exp Gerontol. 2001;36:1713-1726.
31. Li H, Dryhurst G. Irreversible inhibition of mitochondrial complex-I by 7-(-2aminoethyl) 3,4-dihydro-5-hydroxy 2H 1,4-benzothiazine-3-corboxylic acid (DHBT-1) a putative nigral endotoxin of relevance to Parkinson's disease. J Neurochem. 1997;69:1530-1541.
32. + and adenosine triphosphate in isolated brain synaptosomes. J General Physiol. 1990;95:591-616.
33. Jackson GR, Apfell L, Werrbach-Parex, Perez-Polo JR. Role of nerve growth factor in oxidant and antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance. J Neurosci. 1990;25:360-369.
34. Levi-Monlalcini R. The nerve growth factor 35 years later. Science. 1987;237:1154-1162.
35. Whittemore SR, Seiger A. The expression, localization and functional significance of β-nerve growth factor in the central nervous system. Brain Res. 1987;12:439-464.
36. Sampath D, Jackson GR, Werrbach-Perez K, Perez-Polo JR. Effects of nerve growth factor on glutathione peroxidase and catalase in PC12 cells. J Neurochem. 1994;62:2476-2479.
37. Pradhan SN. Central neurotransmitters and aging. Life Sci. 1980;26:1643-1656.
38. Tempesta E, Janiri L, Pirrongelli C. Stereospecific effects of acetylcarnitine on the spontaneous activity of brainstem neurons and their responses to acetylcholine and serotonin. Neuropharmacol. 1985; 24:43-50.
39. Lohninger S, Strasser A, Bubna-Littitz H. The effect of L-carnitine on T-maze leaming ability in aged rats. Arch Gerontol Geriatr. 2001; 32:245-253.