Simulation of the effect of intrinsic reaction kinetics and particle size on the behaviour of immobilised enzymes under internal diffusional restrictions and steady state operation

Process Biochemistry

Volumn 39, Issue 3, 2003, Pages 393-399

  Jeison, D ^a   Ruiz, G ^b   Acevedo, F ^b   Illanes, A ^b  

^a UNIVERSIDAD DE LA FRONTERA   (Chile)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO   (Chile)

Author keywords

Diffusional restrictions; Effectiveness factor; Immobilised enzyme; Kinetic models; Modeling

Indexed keywords

EID: 0345015884     PISSN: 13595113     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0032-9592(03)00129-8     Document Type: Article

References (12)

1. Cabral J, Boross L, Tramper J. Applied biocatalysis. Chur: Harwood Academic Publishers, 1994.
2. D'Souza S. Immobilized enzymes in bioprocess. Curr Sci 1999;77:69-77.
3. Illanes A. Stability of biocatalysts, EJB: Electronic J Biotechnol [on line], vol. 2, no. 1. Valparaiso (Chile): Universidad Católica de Valparaíso, April 1999. Available from http://www.ejb.org.
4. Arroyo M. Immobilized enzymes: theory, methods of study and applications. Ars Pharm 1998;39:111-27.
5. Hartmeier W. Immobilized biocatalyst: from simple to complex systems. Trends Biotechnol 1985;3:149-53.
6. Katchalsky-Katiz E. Immobilized enzymes - learning from past successes and failures. Trends Biotechnol 1993;11:471-8.
7. Bódalo A, Gómez J, Gómez E, Bastida J, Martínez E. Transient stirred-tank reactors operating with immobilised enzyme systems: analysis and simulation models and their experimental checking. Biotechnol Prog 1993;9:166-73.
8. Handriková G, Štefuca V, Polakovič M, Báleš V. Determination of effective diffusion coefficient of substrate in gel particles with immobilised biocatalyst. Enzyme Microb Tech 1996;18:581-4.
9. Kiesser T, Oertzen G, Bauer W. Modelling of a fluidised bed bioreactor for immobilised enzymes (part 1). Chem Eng Technol 1990;13:20-6.
10. Yankov D, Sapundzhiev C, Beschkov V. Modelling of enzyme hydrolysis of maltose in a single pellet of immobilised biocatalyst. Bioprocess Eng 1996;14:219-22.
11. Bailey J, Ollis O. Biochemical engineering fundamentals, 2nd ed. New York: McGraw-Hill, 1986.
12. Xiu G, Jiang L, Li P. Mass-transfer limitations for immobilised enzyme-catalyzed kinetic resolution of racemate in a batch reactor. Ind Eng Chem Res 2000;39:4054-62.