Cytokines in implantation

Cytokine and Growth Factor Reviews

Volumn 9, Issue 3-4, 1998, Pages 287-296

  Rice, Anne ^a   Chard, Tim ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

(Early) pregnancy; Blastocyst; Endometrium; Implantation; Trophoblast

Indexed keywords

CYTOKINE;

ANIMAL; BLASTOCYST; CYTOKINE PRODUCTION; ENDOMETRIUM; FEMALE; HUMAN; IMMUNOLOGY; NIDATION; PHYSIOLOGY; PREGNANCY; REVIEW; TROPHOBLAST; TUMOR IMMUNITY;

EID: 0345003724     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6101(98)00020-3     Document Type: Short Survey

References (128)

1. Barker DJP, Gluckman PD, Godfrey KM, et al. Fetal nutrition and cardiovascular disease in adult life. Lancet 1993, 341, 938-941.
2. Tabibzadeh S, Babaknia A. The signals and molecular pathways involved in implantation, a symbiotic interaction between blastocyst and endometrium involving adhesion and tissue invasion. Hum Reprod 1995, 10, 1579-1602.
3. Chard T. Cytokines in implantation. Hum Reprod Update 1995, 1, 385-396.
4. Simon C, Gimeno MJ, Mercader A, et al. Cytokines-adhesion molecules-invasive proteinases. The missing paracrine/autocrine link in embryonic implantation? Mol Hum Reprod 1996, 2, 405-424.
5. Cohen S, Ward PA, Bigazzi PE. In McCluskey RT, Cohen S, (Eds). Mechanisms of cell-mediated immunity. New York: J Wiley and Sons, 1974.
6. Meager A. Cytokines. Milton Keynes: Open University Press, 1990.
7. Giudice LC, Saleh W. Growth factors in reproduction. Trends Endocrinol Metab 1995, 6, 60-69.
8. Kishimoto T, Taga T, Akira S. Cytokine signal transduction. Cell 1994, 76, 253-262.
9. Simon C, Frances A, Pellicer A. Cytokines in implantation. Semin Reprod Endocrinol 1995, 13, 142-151.
10. Tazuke SI, Giudice LC. Growth factors and cytokines in endometrium, embryonic development and maternal:embryonic interactions. Semin Reprod Endocrinol 1996, 3, 231-245.
11. Kauma S, Matt D, Stromn S, et al. Interleukin-1β, human leukocyte antigen HLA-DRα and transforming growth factor-β expression in endometrium, placenta and placental membranes. Am J Obstet Gynecol 1990, 163, 2430-2438.
12. Kauma WW, Auckerman SL, Eireman D, et al. Colony-stimulating factor-1 and c-fms expression in human endometrial tissues and placenta during the menstrual cycle and early pregnancy. J Clin Endocrinol 1991, 73, 746-751.
13. Kameda T, Matsuzaki N, Sawai K, et al. Production of interleukin-6 by normal human trophoblast. Placenta 1990, 11, 205-213.
14. Hunt JS, Chen HL, Hu XL, et al. Normal distribution of tumour necrosis factor-α messenger ribonucleic acid and protein in the uteri, placentas and embryos of osteopetrotic (op/op) mice lacking colony-stimulating factor-1. Biol Reprod 1993, 49, 441-452.
15. Hunt JS, Chen HL, Hu XL, et al. Tumour necrosis factor-α messenger ribonucleic acid and protein in human endometrium. Biol Reprod 1992, 47, 141-147.
16. Hu XL, Yang Y, Hunt JS. Differential distribution of interleukin-1α and interleukin-1β proteins in human placentas. J Reprod Immunol 1992, 22, 257-268.
17. Horowitz GM, Scott RTJnr, Drews MR, et al. Immunohistochemical localization of transforming growth factor-α in human endometrium, decidua and trophoblast. J Clin Endocrinol Metab 1993, 76, 786-792.
18. Graham CH, Lysiak JJ, McCrae KR, et al. Localization of transforming growth factor-β at the human fetal-maternal interface: role in trophoblast growth and differentiation. Biol Reprod 1992, 46, 561-572.
19. Le Fourie R, Huyser C, Bosmans E, et al. Cytokine (IL-β and IL-6) and growth hormone concentrations in human follicular fluid. Hum Reprod 1994, 9, 136.
20. Delassus S, Coutinho GC, Saucier C, et al. Differential cytokine expression in maternal blood and placenta during murine gestation. J Immunol 1994, 152, 2411-2420.
21. De M, Sanford TR, Wood GW. Expression of interleukin 1, interleukin 6 and tumour necrosis factor-α in mouse uterus during the peri-implantation period of pregnancy. J Reprod Fertil 1993, 97, 83-89.
22. Daiter E, Pampfer S, Yeung TG, et al. Expression of colony-stimulating factor-1 in the human uterus and placenta. J Clin Endocrinol Metab 1992, 74, 850-858.
23. Chen HL, Yang Y, Xiao-Ling H, et al. Tumour necrosis factor-α mRNA and protein are present in human placental and uterine cells at early and late stages of gestation. Am J Pathol 1991, 139, 327-335.
24. Boehm KD, Kelley MF, Ilan J, et al. The interleukin 2 gene is expressed in the syncytiotrophoblast of the human placenta. Proc Natl Acad Sci U.S.A. 1989, 86, 656-660.
25. Bissonnette F, Cook C, Geoghegan T, et al. Transforming growth factor-α and epidermal growth factor messenger ribonucleic acid and protein levels in human placentas from early, mid and late gestation. Am J Obstet Gynecol 1992, 166, 192-199.
26. Bili H, Tarlatzis BC, Daniilidis M, et al. Cytokines and leukotriene B4 levels in human periovulatory follicular fluid and in preimplantation embryo culture media. Hum Reprod 1994, 9, 11-12.
27. Bhatt H, Brunet LJ, Stewart CL. Uterine expression of leukaemia inhibitory factor coincides with the onset of blastocyst implantation. Proc Natl Acad Sci U.S.A. 1991, 88, 11,408-11,412.
28. Arceci RJ, Shanahan F, Stanley ER, et al. Temporal expression and location of colony-stimulating factor 1 (CSF-1) and its receptor in the female reproductive tract are consistent with CSF-1 regulated placental development. Proc Natl Acad Sci U.S.A. 1989, 86, 8818-8822.
29. Barak V, Mordel N, Zajicek G, et al. The correlation between interleukin 2 and soluble interleukin 2 receptors to oestradiol, progesterone and testosterone levels in periovulatory follicles in in vitro fertilization patients. Hum Reprod 1992, 7, 926-929.
30. Zolti M, Ben-Fafael Z, Meirom R, et al. Cytokine involvement in oocytes and early embryos. Fertil Steril 1991, 56, 265-272.
31. Yelavarthi KK, Hunt JS. Analysis of p60 and p80 tumour necrosis factor-α receptor messenger RNA and protein in human placentas. Am J Pathol 1993, 143, 1131-1141.
32. Vince G, Shorter S, Starkey P, et al. Localization of tumour necrosis factor production in cells at the materno-fetal interface in human pregnancy. Clin Exp Immunol 1992, 88, 174-180.
33. Tamada H, McMaster MT, Flanders K, et al. Cell type specific expression of TGF-β-1 in the mouse uterus during the peri-implantation period. Mol Endocrinol 1990, 4, 965-972.
34. Tamada H, Das SK, Andrews GK, et al. Cell type specific expression of TGF-α in the mouse uterus during the peri-implantation period. Biol Reprod 1991, 45, 365-372.
35. Simon C, Frances A, Piquette G, et al. Interleukin-1 system in the materno-trophoblast unit in human implantation: immunohistochemical evidence for autocrine/ paracrine function. J Clin Endocrinol Metab 1994a, 78, 847-854.
36. Shorter SC, Vince GS, Starkey PM. Production of granulocyte colony-stimulating factor at the materno-fetal interface in human pregnancy. Immunology 1992, 75, 468-474.
37. Sheth KV, Roca GL, Al-Sedairy ST, et al. Prediction of successful embryo implantation by measuring interleukin-1α and immunosuppressive factor(s) in preimplantation embryo culture fluid. Fertil Steril 1991, 55, 952-907.
38. Selick CE, Horowitz GM, Gratch M, et al. Immunohistochemical localization of transforming growth factor-β in human implantation sites. J Clin Endocrinol Metab 1994, 78, 592-596.
39. Paria BC, Jones KL, Flanders KC, et al. Localization and binding of transforming growth factor-β isoforms in mouse preimplantation embryos and in delayed and activated blastocysts. Dev Biol 1992, 151, 91-104.
40. Kojima K, Kanzaki H, Iwai M, et al. Expression of leukaemia inhibitory factor in human endometrium and placenta. Biol Reprod 1994, 50, 882-887.
41. Murray R, Lee F, Chiu CP. The genes for leukaemia inhibitory factor and interleukin-6 are expressed in mouse blastocysts prior to the onset of haemopoiesis. Mol Cell Biol 1990, 10, 4953-4956.
42. Kohchi C, Noguchi K, Tanabe Y, et al. Constitutive expression of TNFα and β genes in mouse embryo: roles of cytokines as regulator and effector on development. Int J Biochem 1994, 26, 111-119.
43. Shen MM, Leder P. Leukaemia inhibitory factor is expressed by the preimplantation uterus and selectively blocks primitive ectoderm formation in vitro. Proc Natl Acad Sci U.S.A. 1992, 89, 8240-8244.
44. Tabibzadeh S, Sun XZ. Cytokine expression in human endometrium throughout the menstrual cycle. Hum Reprod 1992, 7, 1214-1221.
45. Clark DA, Vince G, Flanders KC, et al. CD56+ lymphoid cells in human first trimester pregnancy decidua as a source of novel transforming growth factor-β2-related immunosuppressive factors. Hum Reprod 1994, 9, 2270-2277.
46. Haynes MK, Jackson LG, Tuan RS, et al. Cytokine production in first trimester chorionic villi: detection of mRNAs and protein products in situ. Cell Immunol 1993, 151, 300-308.
47. Austgulen R, Arntzen KJ, Vatten LJ, et al. Detection of cytokines (interleukin-1, interleukin-6, transforming growth factor-β) and soluble tumour necrosis factor receptors in embryo culture fluids during in vitro fertilization. Hum Reprod 1995, 10, 171-176.
48. Aboagye-Mathiesen G, Toth FD, Zdravkovic M, et al. Human trophoblast interferons: production and possible roles in early pregnancy. Early Pregnancy:Biol Med 1995, 1, 41-53.
49. Lysiak JJ, Hunt J, Pringle GA, et al. Localization of transforming growth factor β and its natural inhibitor decorin in the human placenta and decidua throughout gestation. Placenta 1995, 16, 221-231.
50. Chen DB, Hilsenrath R, Yang ZM, et al. Leukaemia inhibitory factor in human endometrium during the menstrual cycle: cellular origin and action on production of glandular epithelial cell prostaglandin in vitro. Hum Reprod 1995, 10, 911-918.
51. Tabibzadeh S, Zupi E, Babaknia A, et al. Site and menstrual cycle-dependent expression of proteins of the tumour necrosis factor (TNF) receptor family and BCL-2 oncoprotein and phase-specific production of TNFα in human endometrium. Hum Reprod 1995, 10, 277-286.
52. Roby KF, Hunt JS. Mouse endometrial tumour necrosis factor-α messenger ribonucleic acid and protein: localization and regulation by oestradiol and progesterone. Endocrinology 1994, 135, 2780-2789.
53. Cullinan EB, Abbondanzo SJ, Anderson PS, et al. Leukaemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine/paracrine function in regulating embryo implantation. Proc Natl Acad Sci U.S.A. 1996, 93, 3115-3120.
54. Tamada H, Sakamoto M, Sakaguchi H, et al. Evidence for the involvement of transforming growth factor-α in implantation in the mouse. Life Sci 1997, 60, 1515-1522.
55. De Los Santos MJ, Mercader A, Frances A, et al. Role of endometrial factors in regulating secretion of components of the immunoreactive human embryonic interleukin-1 system during embryonic development. Biol Reprod 1996, 54, 563-574.
56. Dore JJJnr, Wilkinson JE, Godkin JD. Ovine endometrial expression of transforming growth factor-β isoforms during the peri-implantation period. Biol Reprod 1996, 54, 1080-1087.
57. Sawai K, Matsuzaki N, Kameda T, et al. Leukaemia inhibitory factor produced at the feto-maternal interface stimulates chorionic gonadotrophin production: its possible implication during pregnancy including the implantation period. J Clin Endocrinol Metab 1995, 80, 1449-1456.
58. Wood GW, Hausmann E, Choudhuri R. Relative role of CSF-1, MCP-1/JE and RANTES in macrophage recruitment during successful pregnancy. Mol Reprod Dev 1997, 46, 62-69.
59. Sharkey ME, Adler RR, Brenner CA, et al. Matrix metalloproteinase expression during mouse peri-implantation development. Am J Reprod Immunol 1996, 36, 72-80.
60. Simon C, Mercader A, Gimeno MJ, et al. The interleukin-1 system and human implantation. Am J Reprod Immunol 1997, 37, 64-72.
61. Pampfer S, Daiter E, Barad D, et al. Expression of colony-stimulating factor-1 receptor (c-fms proto-oncogene product) in the human uterus and placenta. Biol Reprod 1992, 46, 48-57.
62. Starkey PM. Expression on cells of early human pregnancy decidua, of the p75, IL-2 and p145, IL-4 receptor proteins. Immunology 1991, 73, 64-70.
63. Simon PL, Kumar V, Lillquist JS, et al. Mapping of neutralizing epitopes and the receptor binding site of human interleukin-1β. J Biol Chem 1993, 268, 9771-9779.
64. Hampson J, McLaughlin PJ, Johnson PM. Low-affinity receptors for tumour necrosis factor-α, interferon γ and granulocyte-macrophage colony-stimulating factor are expressed on human placental syncytiotrophoblast. Immunology 1993, 79, 485-490.
65. Hunt JS, Roby KF. Implantation factors. Clin Obstet Gynaec 1994, 37, 635-645.
66. Hill JA, Haimovici F, Anderson DJ. Products of activated lymphocytes and macrophages inhibit mouse embryo development in vitro. J Immunol 1987, 139, 2250-2254.
67. Armstrong DTA, Chaouat G. Effects of lymphokines and immune complexes on murine placental cell growth. Biol Reprod 1989, 40, 466-474.
68. Banfi G, Marinelli M, Casari E, et al. Isotopic and non-isotopic assays for measuring somatotropin compared: reevaluation of cutoff value in provocative tests. Clin Chem 1991, 37, 273-276.
69. Pollard JW, Hunt JS, Wiktor-Jedrzejczak W, et al. A pregnancy defect in the osteopetrotic (op/op) mouse demonstrates the requirement for CSF-1 in female fertility. Dev Biol 1991, 148, 273-283.
70. Tartakovsky B, Ben-Yair E. Cytokines modulate pre-implantation development and pregnancy. Dev Biol 1991, 146, 345-352.
71. Tartakovsky B, Goldstein C, Brosh N. Colony-stimulating factor-1 blocks early pregnancy in mice. Biol Reprod 1991, 44, 906-912.
72. Pollard JW, Bartocci A, Arceci R, et al. Apparent role of the macrophage growth factor, CSF-1, in placental development. Nature 1987, 330, 484-486.
73. Bartocci A, Pollard JW, Stanley ER. Regulation of colony-stimulating factor 1 during pregnancy. J Exp Med 1986, 164, 956-961.
74. Cohen PE, Zhu L, Pollard JW. Absence of colony-stimulating factor 1 in osteopetrotic (csfmop/csfmop) mice disrupts estrous cycles and ovulation. Biol Reprod 1997, 56, 110-118.
75. Chaouat G, Menu E, Clark DA, et al. Control of fetal survival in CBAxDBA/2 mice by lymphokine therapy. J Reprod Fertil 1990, 89, 447-458.
76. Lea RG, Clark DA. Effects of decidual cell supernatants and lymphokines on murine trophoblast growth in vitro. Biol Reprod 1993, 48, 930-935.
77. Azuma C, Saji F, Kimura T, et al. The gene expressions of macrophage colony-stimulating factor (MCSF) and MCSF receptor in the human myometrium during pregnancy: regulation by sex steroid hormones. J Steroid Biochem 1991, 39, 883-888.
78. Haimovici F, Hill JA, Anderson DJ. The effects of soluble products of activated lymphocytes and macrophages on blastocyst implantation events in vitro. Biol Reprod 1991, 44, 69-75.
79. Hatayama H, Kanzaki H, Iwai M, et al. Progesterone enhances macrophage colony-stimulating factor production in human endometrial stromal cells in vitro. Endocrinology 1994, 135, 1921-1927.
80. Laird SM, Tuckerman E, Li TC, et al. Stimulation of human endometrial epithelial cell interleukin-6 production by interleukin-1 and placental protein 14. Hum Reprod 1994, 9, 1339-1343.
81. Feinberg BB, Anderson DJ, Steller MA, et al. Cytokine regulation of trophoblast steroidogenesis. J Clin Endocrinol Metab 1994, 78, 586-591.
82. Fakih H, Baggett B, Holtz G, et al. Interleukin-1: a possible role in infertility associated with endometriosis. Fertil Steril 1987, 47, 213-217.
83. Masuhiro K, Matsuzaki N, Nishino E, et al. Trophoblast-derived interleukin-1 (il-1) stimulates the release of human chorionic gonadotrophin by activating IL-6 and IL-6 receptor system in first trimester human trophoblasts. J Clin Endocrinol Metab 1991, 72, 594-601.
84. Simon C, Francis A, Piquette GN, et al. Embryonic implantation in mice is blocked by interleukin-1 receptor antagonist. Endocrinology 1994b, 134, 521-528.
85. Tabibzadeh S, Kaffka KL, Satyaswaroop PG, et al. Interleukin-1 regulation of human endometrial function: presence of IL-1 receptor correlates with IL-1 stimulated prostaglandin E2 production. J Clin Endocrinol Metab 1990, 70, 1000-1006.
86. Tabibzadeh S, Santhanam U, Sehgal PB, et al. Cytokine-induced production of IFN-β 2/IL-6 by freshly explanted human endometrial stromal cells. Modulation by estradiol-17β. J Immunol 1989, 142, 3134-3139.
87. Kauma SW, Turner TT, Harty JR. Interleukin-1β stimulates interleukin-6 production in placental villous core mesenchymal cells. Endocrinology 1994, 134, 457-460.
88. Silen ML, Firpo A, Francus T, et al. The effect of interleukin-1α and tumour necrosis factor α on the secretion of human chorionic gonadotrophin by JAR human choriocarcinoma cells. Biochem Biophys Res Commun 1989, 164, 284-289.
89. Yagel S, Lia PK, Powell WA, et al. Interleukin-1 stimulates human chorionic gonadotrophin secretion by first trimester human trophoblast. J Clin Endocrinol Metab 1989, 68, 992.
90. Jikihara H, Posner AM, Handwerger S. Tumour necrosis factor-α and interleukin-1β inhibit the synthesis and release of renin from human decidual cells. J Clin Endocrinol Metab 1995, 79, 195-200.
91. Tezabwala BU, Johnson PM, Rees RC. Inhibition of pregnancy viability in mice following IL-2 administration. Immunology 1989, 67, 115-119.
92. Stephanou A, Handwerger S. Interleukin-6 stimulates placental lactogen expression by human trophoblast cells. Endocrinology 1994, 135, 719-723.
93. Nishino E, Matsuzaki N, Masuhiro K, et al. Trophoblast-derived interleukin-6 (IL-6) regulates human chorionic gonadotrophin release through IL-6 receptor on human trophoblasts. J Clin Endocrinol Metab 1990, 71, 436-441.
94. Wegman TG, Lin H, Guilbert L, et al. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 1993, 14, 353-356.
95. Li Y, Matsuzaki N, Masuhiro K, et al. Trophoblast-derived tumour necrosis factor-α induces release of human chorionic gonadotrophin using interleukin-6 (IL-6) and IL-6-receptor-dependent system in the normal human trophoblasts. J Clin Endocrinol Metab 1992, 74, 184-191.
96. Lachapelle MH, Miron P, Hemmings R, et al. Embryonic resistance to tumour necrosis factor-α mediated cytoxicity: novel mechanism underlying maternal immunological tolerance to the fetal allograft. Hum Reprod 1993, 8, 1032-1038.
97. Jikihara H, Handwerger S. Tumour necrosis factor-α inhibits synthesis and release of human decidual prolactin. Endocrinology 1994, 143, 353-357.
98. Inoue T, Kanzaki H, Imai K, et al. Tumour necrosis factor-α inhibits in vitro decidualization of human endometrial stromal cells. Hum Reprod 1994, 9, 2411-2417.
99. Pampfer S, Wuu YD, Vanderheyden I, et al. Expression of tumour necrosis factor-α receptors and selective effect of TNFα on the inner cell mass in mouse blastocysts. Endocrinology 1994, 134, 206-212.
100. Krishnan L, Guilbert LJ, Wegman TG, et al. T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-γ and TNF and reduced IL-10 production by placental cells. J Immunol 1996, 156, 653-662.
101. Paria BC, Dey SK. Preimplantation embryo development in vitro: cooperative interactions among embryos and role of growth factors. Dev Biol 1990, 87, 4756-4760.
102. Matsuzaki N, Li Y, Masuhiro K, et al. Trophoblast-derived transforming growth factor-β 1 suppresses cytokine-induced, but not gonadotrophin-releasing hormone-induced, release of human chorionic gonadotrophin by normal human trophoblasts. J Clin Endocrinol Metab 1992, 74, 211-216.
103. Slager HG, Van Inzen W, Freund E, et al. Transforming growth factor-β in the early mouse embryo: implications for the regulation of muscle formation and implantation. Dev Genet 1993, 14, 212-224.
104. Lysiak JL, Connelly IH, Khoo NKS, et al. Role of transforming growth factor-α and epidermal growth factor on proliferation and invasion by first trimester human trophoblast. Trophoblast Res 1994, 8, 455-467.
105. Das SK, Lim H, Wang J, et al. Inappropriate expression of human transforming growth factor-α in the uterus of transgenic mouse causes downregulation of TGF-β receptors and delays the blastocyst-attachment reaction. J Mol Endocrinol 1997, 18, 243-257.
106. Stewart CL, Kaspar P, Brunet LJ, et al. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 1987, 359, 76-79.
107. Fry RC, Batt PA, Fairclough RJ, et al. Human leukaemia inhibitory factor improves the viability of cultured ovine embryos. Biol Reprod 1992, 46, 470-474.
108. Godkin JD, Smith SE, Johnson RD, et al. The role of trophoblast interferons in the maintenance of early pregnancy in ruminants. Am J Reprod Immunol 1997, 37, 137-143.
109. Bazer FW, Spencer TE, Ott TL. Interferon tau: a novel pregnancy recognition signal. Am J Reprod Immunol 1997, 37, 412-420.
110. Hansen TR, Imakawa K, Polites HG, et al. Interferon RNA of embryonic origin is expressed transiently during early pregnancy in the ewe. J Biol Chem 1988, 263, 12,801-12,804.
111. Vallet JL, Bazer FW, Fliss MF, et al. Effect of ovine conceptus secretory proteins and purified ovine trophoblast protein-1 on interoestrous interval and plasma concentrations of prostaglandins F-1α and E and of 13, 14-dihydro-15-keto prostaglandin F-2α in cyclic ewes. J Reprod Fertil 1988, 84, 493-504.
112. Stewart HJ, McCann SHE, Barker PJ, et al. Interferon sequence homology and receptor binding activity of ovine trophoblast antiluteolytic protein. J Endocrinol 1987, 115, R13-R15.
113. Imakawa K, Anthony RV, Kazemi M, et al. Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm. Nature 1987, 330, 377-379.
114. Pontzer CH, Torres BA, Vallet JL, et al. Antiviral activity of the pregnancy recognition hormone ovine trophoblast protein-1. Biochem Biophys Res Commun 1988, 152, 801-807.
115. Charlier M, Hue D, Martal J, et al. Cloning and expression of cDNA encoding ovine trophoblastin: its identity with a class-II α interferon. Gene 1989, 77, 341-348.
116. Stewart HJ, McCann SH, Northrop AJ, et al. Sheep antiluteolytic interferon: cDNA sequence and analysis of mRNA. J Mol Endocrinol 1989, 2, 65-70.
117. Stewart HJ, McCann SH, Flint AP. Structure of an interferon-α 2 gene expressed in the bovine conceptus early in gestation. J Mol Endocrinol 1990, 4, 275-282.
118. Imakawa K, Hansen TR, Malathy PV, et al. Molecular cloning and characterization of complementary deoxyribonucleic acids corresponding to bovine trophoblast protein-1 and bovine interferon-α II. Mol Endocrinol 1989, 3, 127-139.
119. Gnatek GG, Smith LD, Duby RT, et al. Maternal recognition of pregnancy in the goat: effects of conceptus removal on interestrus intervals and characterization of conceptus protein production during early pregnancy. Biol Reprod 1989, 41, 655-663.
120. Cross JC, Roberts RM. Porcine conceptuses secrete an interferon during the preattachment period of early pregnancy. Biol Reprod 1989, 40, 1109-1118.
121. Chard T. Interferon in pregnancy. J Dev Physiol 1989, 11, 271-276.
122. Chard T. Interferon α is a reproductive hormone. J Endocrinol 1991, 131, 337-338.
123. Chard T, Craig PH, Menabawey M, et al. Alpha interferon in human pregnancy. Br J Obstet Gynaecol 1986, 93, 1145-1149.
124. Gunn LK, Homa ST, Searle MJ, et al. Lack of evidence for the production of interferon- α- like species by the cultured human embryo. Hum Reprod 1994, 9, 1522-1527.
125. Iles RK, Chard T. Enhancement of ectopic β-human chorionic gonadotrophin expression by interferon. J Endocrinol 1989, 123, 501-507.
126. Grabowska A, Chumbley G, Carter N, et al. Interferon γ enhances mRNA and surface expression of class I antigen on human extravillous trophoblast. Placenta 1990, 11, 301-308.
127. Polgar K, Yacono PW, Golan DE, et al. Immune interferon γ inhibits translational mobility of a plasma membrane protein in preimplantation stage mouse embryos: a T-helper 1 mechanism for immunologic reproductive failure. Am J Obstet Gynecol 1996, 174, 282-287.
128. Guilbert L, Robertson SA, Wegman TG. The trophoblast as an integral component of a macrophage-cytokine network. Immunol Cell Biol 1993, 71, 49-57.