The platelet window: Examining receptor regulated second messenger processes in psychosis and depression

Acta Neuropsychiatrica

Volumn 15, Issue 6, 2003, Pages 309-315

  Berk, Michael ^a   Malhi, G S ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Intracellular calcium response; Major depression; Peripheral markers; Platelet; Psychiatric illness; Psychosis; Second messengers

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE; ADENOSINE RECEPTOR BLOCKING AGENT; DOPAMINE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SEROTONIN; SEROTONIN 2 RECEPTOR;

CALCIUM SIGNALING; DEPRESSION; PATHOPHYSIOLOGY; PSYCHOSIS; REGULATORY MECHANISM; REVIEW; SECOND MESSENGER; SENSITIVITY AND SPECIFICITY; THROMBOCYTE;

EID: 0344982914     PISSN: 09242708     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1601-5215.2003.00048.x     Document Type: Review

References (64)

1. PEARSE AGE. The diffuse neuroendocrine system: Peptides, amines, placodes and the APUD theory. Progr Brain Res 1986;68:25-31.
2. LESCH KP, WOLOZIN BL, MURPHY DL et al. Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J Neurochem 1993;60:2319-2322.
3. STAHL SM. The human platelet. A disgnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders. Arch General Psychiatry 1977;34:509-516.
4. DA PRADA M, CESURA AM, LAUNAY JM et al. Platelets as a model for neurones? Experentia 1988;44:115-126.
5. BERK M, BODEMER W, VAN OUDENHOVE T et al. Dopamine increases platelet intracellular calcium in bipolar disorder and controls. Int Clin Pharmacol 1994;9:291-293.
6. PLEIN H, BERK M. The platelet as a peripheral marker in psychiatric illness. Hum Psychopharmacol 2001;16:229-236.
7. LEONARD BE. Fundamentals of Psychopharmacology. Chichester: John Wiley, 1992.
8. AROLT V, ROTHERMUNDT M, PETERS M, LEONARD B. Immunological research in clinical psychiatry: report on the consensus debate during the 7th expert meeting on psychiatry and immunology. Mol Psychiatry 2002;7:822-826.
9. DUBOVSKY SL, CHRISTIANO J, DANIELL LC et al. Increased platelet intracellular calcium concentration in patients with bipolar affective disorders. Arch General Psychiatry 1989;46:632-638.
10. BOWDEN CL, HUANG LG, JAVORS MA et al. Calcium function in affective disorders and healthy controls. Biol Psychiatry 1988;23:367-376.
11. DUBOVSKY SL, LEE C, CHRISTIANO J, MURPHY J. Elevated platelet intracellular calcium concentration in bipolar depression. Biol Psychiatry 1991;29:441-450.
12. BERK M, BODEMER W, VAN OUDENHOVE T, BUTKOW N. The platelet intracellular calcium response to serotonin is augmented in bipolar manic and depressed patients. Hum Psychopharmacol Clin Exp 1995;10:189-193.
13. DUBOVSKY SL, MURPHY J, THOMAS M, RADEMACHER J. Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients. Am J Psychiatry 1992;149:118-120.
14. EMAMGHOREISHI M, SCHLICHTER L, LI PP et al. High intracellular calcium concentrations in transformed lymphoblasts from subjects with bipolar I disorder. Am J Psychiatry 1997;154:976-982.
15. WALTON SA, BERK M, BROOK S. Superiority of lithium over verapamil in mania: a randomised controlled single blind trial. J Clin Psychiatry 1996;57:543-546.
16. TAN CH, JAVORS MA, SELESHI E, LOWRIMORE PA, BOWDEN CL. Effects of lithium on platelet ionic intracellular calcium concentration in patients with bipolar (manic-depressive) disorder and healthy controls. Life Sci 1990;46:1175-1180.
17. 2+ uptake into platelets in bipolar disorder and controls. Clin Neuropharmacol, 1996;19:48-51.
18. ARORA RC, MELTZER HY. Increased serotonin 2 receptor binding as measured by 3H-LSD binding in blood platelets of depressed patients. Life Sci 1989;44:725-734.
19. ARORA RC, MELTZER HY. Serotonin 2 receptor binding in blood platelets of schizophrenic patients. Psychiatr Res 1993;47:111-119.
20. BAKISH D, CAVAZZONI P, CHUDZIK J et al. Effects of serotonin reuptske inhibitors on platelet serotonin parameters in major depressive disorder. Biol Psychiatry 1997;41:184-190.
21. 2 receptor binding on blood platelets of suicidal men. Psychopharmacol (Berl) 1990;100:165-167.
22. BUTLER J, O'HALLORAN A, LEONARD BE. The Galway study of panic disorder II. Changes in some peripheral markers of noradrenergic and serotonergic function in DSM III-R panic disorder. J Affect Disord 1992;26:89-99.
23. NUGENT DF, DINAN TG, LEONARD BE. Further characterization of the inhibition of platelet aggregation by a plasma factor(s) in unmedicated unipolar depressed patients. J Affect Disord 1995;33:227-231.
24. 2A receptors unchanged by antidepressant treatment. Psychiatr Res 1997;66:73-85.
25. ALVAREZ JC, GLUCK N, ARNULF I et al. Decreased platelet serotonin transporter sites and increased platelet inositol triphosphate levels in patients with unipolar depression: effects of clomipramine and fluoxetine. Clin Pharmacol Therap 1999;66:617-624.
26. MENDELSON SD. The current status of the platelet 5-HT(2A) receptor in depression. J Affect Disord 2000;57:13-24.
27. KUSUMI I. Serotonin-2 receptor-mediated intraplatelet calcium mobilization in affective disorders: relevance to the pathophysiology of depression. Hokkaido Igaku Zasshi 1993;68:325-336.
28. MIKUNI M, KAGAYA A, TAKAHASHI K et al. Serotonin but not norepinephrine induced calcium mobilization of platelets is enhanced in affective disorders. Psychopharmacol 1992;106:311-314.
29. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985;260:3440-3450.
30. 2+ uptake. Life Sci 2000;66:425-431.
31. 2+ responses in untreated depressed patients and imipramine responders in remission. Biol Psychiatry 1999;45:1042-1048.
32. DELISI SM, KONOPKA LM, O'CONNOR FL, CRAYTON JW. Platelet cytosolic calcium responses to serotonin in depressed patients and controls: relationship to symptomatology and medication. Biol Psychiatry 1998;43:327-334.
33. KUSUMI I, KOYAMA T, YAMASHITA I. Serotonin-induced platelet intracellular calcium mobilization in depressed patients. Psychopharmacol (Berl) 1994;113:322-327.
34. KUSUMI I, SUZUKI K, SASAKI Y, KAMEDA K, KOYAMA T. Treatment response in depressed patients with enhanced Ca mobilization stimulated by serotonin. Neuropsychopharmacology 2000;23:690-696.
35. 3H]-IMI platelet binding and clinical response in depression? Neuropsychopharmacology 1996;14:47-53.
36. FIGUERAS G, PEREZ V, SAN MARTINO O, ALVAREZ E, GRUPO DE TRASTORNOS AFECTIVOS, ARTIGAS F. Pretreatment platelet 5HT concentration predicts the short term response to paroxetine in major depression. Biol Psychiatry 1999;46:518-524.
37. NEUGER J, WISTED B, SINNER B, ABERG-WISTED A, STAIN-MALMGREN R. The effect of citalopram treatment on platelet serotonin function in panic disorders. Int Clin Psychopharmacol 2000;15:83-91.
38. MARKOVITZ JH, SHUSTER JL, CHITWOOD WS, MAY RS, TOLBERT LC. Platelet activation in depression and effects of sertraline treatment: an open label study. Am J Psychiatry 2000;157:1006-1008.
39. MUSSELMAN DL, MARZEC UM, MANATUNGA A et al. Platelet reactivity in depressed patients treated with paroxetine. Arch General Psychiatry 2000;57:875-882.
40. BERRIDGE MJ. Cytoplasmic calcium oscillations: a two pool model. Cell Calcium 1991;12:63-72.
41. KONOPKA LM, COOPER R, CRAYTON JW. Serotonin-induced increases in platelet cytosolic calcium in depressives, schizophrenic, and substance abuse patients. Biol Psychiatry 1996;39:708-713.
42. OKAMOTO Y, KAGAYA A, TAMIYA S et al. Serotonin-induced platelet calcium mobilisation is enhanced in bulimia nervosa but not anorexia nervosa. Biol Psychiatry 1995;38:274-276.
43. BERK M, MITCHELL VS, PLEIN H. The platelet intracellular calcium response to serotonin in subsyndromal depression. Int Clin Psychopharmacol 1998;13:107-110.
44. KESSLER RC, ZHAO S, BLAZER DG, SWARTZ M. Prevalence, correlates, and course of minor depression and major depression in the National Comorbidity Survey. J Affect Disord 1997;45:19-30.
45. PEIRSON AR, HEUCHERT JW. Correlations for serotonin levels and measures of mood in a nonclinical sample. Psychol Rep 2000;87:707-716.
46. SUZUKI K, KUSUMI I, SASAKI Y, KOYAMA T. Serotonin-induced platelet intracellular calcium mobilization in various psychiatric disorders: is it specific to bipolar disorder? J Affect Disord 2001;64:291-296.
47. YAMAWAKI S, KAGAYA A, OKAMOTO Y, SHIMIZU M, NISHIDA A, UCHITOMI Y. Enhanced calcium response to serotonin in platelets from patients with affective disorders. J Psychiatry Neurosci 1996;21:321-324.
48. BOTHWELL RA, ECCLESTON D, MARSHALL E. Platelet intracellular calcium in patients with recurrent affective disorders. Psychopharmacology (Berl) 1994;114:375-381.
49. PLEIN H, BERK M. The platelet intracellular calcium response to serotonin and thrombin in patients with panic disorder. Eur Neuropsychopharmacol 1999;9:107-110.
50. 3H]-glutamic acid in human platelets. New type of platelet receptors? Biokimiya 1988;53:848-852.
51. GRANT ER, BACSKAI BJ, PLEASURE DE et al. N-methyl-D-aspartate receptors expressed in a non-neuronal cell line mediate subunit-specific increases in free intracellular calcium. J Biol Chem 1997;272:647-656.
52. MANGANO RM, SCHWARCZ R. The human platelet as a model for the glutamatergic neuron: Platelet uptake of 1-glutamate. J Neurochem 1981;36:1067-1076.
53. KIM JS, KORNHUBER HH, SCHMID- BURGK W et al. Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 1980;20:379-382.
54. TSAI G, PASSANI LA, SLUSHER BS et al. Abnormal excitatory neurotransmitter metabolism in schizophrenic brains Arch General Psychiatry 1995;52:829-836.
55. BERK M, PLEIN H, CZISMADIA T. Supersensitive platelet glutamate receptors as a possible peripheral marker in schizophrenia. Int Clin Psychopharmacol 1999;14:119-122.
56. BERK M, PLEIN H, BELSHAM B. The specificity of the platelet glutamate receptor supersensitivity in psychotic disorders. Life Sci 2000;66:2427-2432.
57. BERK M, PLEIN H, FERREIRA D. Platelet glutamate supersensitivity in depression. Int J Neuropsychopharmacol 2000;3:S112.
58. SARGES R, HOWARD HR, BROWNE RG, LEBEL LA, SEYMOUR PA, KOE BK. 4-amino[1,2,4]triazolo[4 3a] quinoxalines: a novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants. J Med Chem 1990;33:2240-2254.
59. WILLIAMS M. Adenosine: The prototypic neuromodulator. Neurochem Inter, 1989;14:249-264.
60. STONE TW, TAYLOR DA. Antidepressant drugs potentiate suppression by adenosine of neuronal firing in rat cerebral cortex. Neurosci Lett, 1979;11:93-97.
61. SHEID B. Trazodone, a non-tricyclic antidepressant, is an inhibitor of adenosine deaminease. Res Commum Chem Pathol Pharmacol 1985;47:149-152.
62. JONZON B, FREDHOLM BB. Adenosine mechanisms are not affected by antidepressant concentrations of desipramine. J Pharm Pharmacol, 1984;36:846-848.
63. WILLIAMS M, RISLEY EA, ROBINSON JL. Chronic in vivo treatment with desmethylimipramine and mianserin does not alter adenosine A-1 radioligand binding in rat cortex. Neurosci Lett 1983;35:47-51.
64. BERK M, PLEIN H, FERREIRA D, JERSKY B. Blunted adenosine A2a receptor function in platelets in patients with major depression. Eur Neuropsychopharmacol 2001;11:183-186.