The activation of parathion by brain and liver of a Brazilian suckermouth benthic fish shows comparable in vitro kinetics

Pesticide Biochemistry and Physiology

Volumn 64, Issue 3, 1999, Pages 149-156

  Cunha Bastos, V L F ^a   Silva Filho, M V ^b   Rossini, A ^a   Cunha Bastos, J ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

PISCES;

EID: 0344980824     PISSN: 00483575     EISSN: None     Source Type: Journal    
DOI: 10.1006/pest.1999.2418     Document Type: Article

References (24)

1. Gaines T. B., Hayes W. J., Linder R. E. Liver metabolism of anticholinesterase compounds in live rats: Relation to toxicity. Nature. 209:1966;88.
2. Kamataki T., Leelin M. C. M., Belcher D. H., Neal R. A. Studies of the metabolism of parathion with an apparently homogenous preparation of rabbit liver microsomal cytochrome P-450. Drug Metab. Dispos. 4:1976;180.
3. Poore R. E., Neal R. A. Evidence for extrahepatic metabolism of parathion. Toxicol. Appl. Pharmacol. 23:1972;759.
4. Chambers J. E., Chambers H. W., Snawder J. E. Target site bioactivation of the neurotoxic organophosphorus insecticide parathion in partially hepatectomized rats. Life Sci. 48:1991;1023.
5. Neal R. A. Studies on the metabolism of diethyl 4-nitrophenyl phosphorothionate (parathion) in vitro. Bio chem. J. 108:1967;183.
6. Benke G. M., Cheever K. L., Mirer F. E., Murphy S. D. Comparative toxicity, anticholinesterase action and metabolism of methyl parathion and parathion in sunfish and mice. Toxicol. Appl. Pharmacol. 28:1974;97.
7. Li W. F., Furlong C. E., Costa L. G. Serum paraox onase status: A major factor in determining resistance to organophosphates. J. Toxicol. Environ. Health. 40:1993;337.
8. Chambers H. W., Brown B., Chambers J. E. Non-catalytic detoxication of six organophosphorus compounds by rat liver homogenates. Pest. Biochem. Physiol. 36:1990;308.
9. Chambers J. E., Carr R. L. Inhibition patterns of brain acetylcholinesterase and hepatic and plasma aliesterases following exposures to three phosphorothionate insecticides and their oxon in rats. Fund. Appl. Toxicol. 21:1993;111.
10. Norman B. J., Poore R. E., Neal R. A. Studies of the binding of sulfur released in the mixed-function oxydase-catalysed metabolism of diethyl p-nitrophenyl phosphorothioate (parathion) to diethyl p-nitrophenyl phosphate (paraoxon). Biochem. Pharmacol. 23:1974;1733.
11. Halpert J., Hammond D., Neal R. A. Inactivation of purified rat liver cytochrome P-450 during the metabolism of parathion (diethyl p-nitrophenyl phosphorothioate). J. Biol. Chem. 255:1980;1080.
12. Butler A. M., Murray M. Inhibition and inactivation of constitutive cytochrome P450 in rat liver by parathion. Mol. Pharmacol. 43:1993;902.
13. Cunha Bastos V. L. F., Cunha Bastos J., Mendonça R. L., Castro Faria M. V. Main Kinetic characteristics of acetylcholinesterase from brain of Hypostomus punctatus, a Brazilian bentonic fish (cascudo). Comp. Biochem. Physiol. 91C:1988;327.
14. Cunha Bastos J., Cunha Bastos V. L. F., Rossini A., Fortini H., Castro Faria M. V. Activation of parathion by liver of Hypostomus punctatus, a Brazilian benthic fish (cascudo). Comp. Biochem. Physiol. 102C:1992;561.
15. Cunha Bastos V. L. F., Rossini A., Alves M. V., Ceccarelli P. S., Ferraz de Lima J. A., Cunha Bastos J. Paraoxonase activity in sera from Piaractus mesopotamicus Holmberg (Characidae) and Hypostomus punctatus Valenciennes (Siluridae). Revta Bras. Zool. 15:1998;665.
16. Peterson G. L. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem. 83:1977;346.
17. Ellman G. L., Courtney K. D., Andres V., Featherstone R. M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7:1961;88.
18. Mesnil M., Testa B., Jenner P. Xenobiotic metabolism by brain monooxigenases and other cerebral enzymes. Adv. Drug Res. 13:1984;95.
19. Iscan M., Reuhl K., Weiss B., Maines M. D. Regional and subcellular distribution of cytochrome P450-dependent drug metabolism in monkey brain: The olfactory bulb and mitochondrial fraction have high levels of activity. Biochem. Biophys. Res. Commun. 169:1990;858.
20. Ghersi-Egea J. F., Perrin R., Leininger-Muller B., Grassiot M. C., Jeandel C., Floquet J., Cuny G., Siest G., Minn A. Subcellular localization of cytochrome P450, and activities of several enzymes responsible for drug metabolism in the human brain. Biochem. Pharmacol. 45:1993;647.
21. Nakatsugawa T., Tolman N. M., Dahm D. A. Degradation and activation of parathion analogs by microsomal enzymes. Biochem. Pharmacol. 17:1968;1517.
22. Neal R. A. Enzymic mechanism of metabolism of phosphorothionate insecticide. Arch. Intern. Med. 128:1971;118.
23. Levi P. E., Hollingworth R. M., Hodgson E. Differences in oxidative dearylation and desulfuration of fenitrothion by cytochrome P450 isozymes and in the subsequent inhibition of monooxygenase activity. Pestic. Biochem. Physiol. 32:1988;224.
24. Ma T., Chambers J. E. A kinetic analysis of hepatic microsomal activation of parathion and chlorpyrifos in control and phenobarbital-treated rats. J. Biochem. Toxicol. 10:1995;63.