Mechanisms of action of melatonin on the human immune system: Membrane versus nuclear receptors

Frontiers of Hormone Research

Volumn 23, Issue , 1997, Pages 43-51

  Guerrero, Juan M ^a   Rafii El Idrissi, Mohammed ^a   Garcia Pergañeda, Antonio ^a   Garcia Mauriño, Sofia ^a   Gil Haba, Maria ^a   Pozo, David ^a   Calvo, Juan R ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0344953516     PISSN: 03013073     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000060985     Document Type: Review

References (30)

1. Reiter RJ: Pineal melatonin: Cell biology of its synthesis and of its physiologic interactions. Endocr Rev 1991;12:151-180.
2. Dubocovich ML: Characterization of a retinal melatonin receptor. J Pharmacol Exp Ther 1985;234:395-401.
3. Stankov B, Reiter RJ: Melatonin receptors: Current status, facts, and hypotheses. Life Sci 1990;46:971-982.
4. Reppert SM, Weaver DR, Rivkees SA, Stopa EG: Putative melatonin receptors in a human biological clock. Science 1989;242:78-81.
5. Weaver DR, Rivkees SC, Reppert SM: Localization and characterization of melatonin receptors in rodent brain by in vitro autoradiography. J Neurosci 1989;9:2581-2590.
6. Laitinen JT, Flügge G, Saavedra JM: Characterization of melatonin receptors in the rat area postrema: Modulation of affinity with cations and guanine nucleotides. Neuroendocrinology 1990;51:619-624.
7. Ebisawa T, Karne S, Lerner MR, Reppert SM: Expression cloning of a high-affinity melatonin receptor from Xanopus dermal melanophores. Proc Natl Acad Sci USA 1994;91:6133-6137.
8. Reppert SM, Weaver DR, Ebisawa T: Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron 1994;13:1177-1185.
9. 1a-melatonin reeptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a). Genomics 1995;27:355-357.
10. 1b melatonin receptor. Proc Natl Acad Sci USA 1995;92:8734-8738.
11. Guerrero JM, Reiter RJ: A brief survey of pineal gland-immune system interrelationships. Endocr Res 1992;18:91-113.
12. Calvo JR, Rafii-El-Idrissi M, Pozo D, Guerrero JM: Immunomodulatory role of melatonin: Specific binding sites in human and rodent lymphoid cells. J Pineal Res 1995;18:119-126.
13. Lopez-Gonzalez MA, Calvo JR, Osuna C, Guerrero JM: Interaction of melatonin with human lymphocytes: Evidence for binding sites coupled to potentiation of cyclic AMP stimulation by vasoactive intestinal peptide and activation of cyclic GMP production. J Pineal Res 1992;12:97-104.
14. Lopez-Gonzalez MA, Calvo JR, Osuna C, Rubio A, Guerrero JM: Synergistic action of melatonin and vasoactive intestinal peptide in stimulating cyclic AMP production in human lymphocytes. J Pineal Res 1992;12:174-181.
15. Lopez-Gonzalez MA, Calvo JR, Segura JJ, Guerrero JM: Characterization of melatonin binding sites in human peripheral blood neutrophils. Biotechnol Ther 1993;4:253-262.
16. Gonzalez-Haba M, Garcia-Mauriño S, Calvo JR, Goberna R, Guerrero JM: High-affinity binding of melatonin by human circulating T lymphocytes (CD4+). FASEB J 1995;9:1331-1335.
17. 125I]iodomel-atonin by rat splenocytes: Characterization and its role on regulation of cyclic AMP production. J Neuroimmunol 1995;57:171-178.
18. 125I]melatonin by partially purified membranes of rat thymus. J Neuroimmunol 1993;45:121-126.
19. 125I]melatonin by rat thymus membranes during postnatal development. Immunol Lett 1993;36:59-64.
20. 125I]melatonin by rat spleen crude membranes: Day-night variations and effect of pinealectomy and continuous light exposure. J Pineal Res 1996;20:33-38.
21. Morgan PJ, Lawson W, Davidson G, Howell HE: Melatonin inhibits cyclic AMP production in cultured ovine pars tuberalis cells. J Mol Endocrinol 1989;3:R5-R8.
22. Carlson LL, Weaver DR, Reppert SM: Melatonin signal transduction in hamster brain: Inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein. Endocrinology 1989;125:2670-2676.
23. Pozo D, Delgado M, Calvo JR, Garcia-Pergañeda A, Guerrero JM: Expression of the membrane melatonin receptor mRNA in rat thymus and spleen; in Maestroni GMJ, Conti A, Reiter AJ (eds): Therapeutic Potential of Melatonin. Front Horm Res. Basel, Karger, 1996, vol 23, pp 36-42.
24. Menendez-Pelaez A, Reiter RJ: Distribution of melatonin in mammalian tissues: The relative importance of nuclear versus cytosolic localization. J Pineal Res 1993;15:59-69.
25. Acuña Castroviejo D, Reiter RJ, Menendez-Pelaez A, Pablos MI, Burgos A: Characterization of high-affinity melatonin binding sites in purified cell nuclei of liver. J Pineal Res 1994;16:100-112.
26. Becker-Andre M, Wiesenberg I, Scaeren-Wiemer N, Andre E, Missbach M, Saurat JH, Carlberg C: Pineal hormone melatonin binds and activates an orphan of the nuclear receptor superfamily. J Biol Chem 1994;269:28531-28534.
27. Pozo D, Reiter RJ, Calvo JR, Guerero JM: Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sci 1994;55:PL455-PL460.
28. Pozo D, Reiter RJ, Calvo JR, Guerrero JM: Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin. J Cell Biochem 1996, in press.
29. Reiter RJ, Melchiori D, Sewerynek E, Poeggeler B. Walden-Barlow LR, Chuang JI, Ortiz GG, Acuña-Castroviejo D: A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 1995;18:1-11.
30. Reiter RJ: Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 1995;9:526-533.