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Volumn 49, Issue 1-2, 2003, Pages 17-23

An in vitro study on the active conversion of flucytosine to fluorouracil by microorganisms in the human intestinal microflora

Author keywords

Conversion; Flucytosine; Fluorouracil; Microorganisms; Toxicity

Indexed keywords

AMPHOTERICIN B; CIPROFLOXACIN; COTRIMOXAZOLE; FLUCONAZOLE; FLUCYTOSINE; FLUOROURACIL; NYSTATIN; PENICILLIN G;

EID: 0344942468     PISSN: 00093157     EISSN: None     Source Type: Journal    
DOI: 10.1159/000069784     Document Type: Article
Times cited : (37)

References (31)
  • 4
    • 0014425886 scopus 로고
    • Treatment of Candida species and Cryptococcus meningitis with 5-fluorocytosine. A new antifungal agent
    • Tassel D, Madoff MA: Treatment of Candida species and Cryptococcus meningitis with 5-fluorocytosine. A new antifungal agent. JAMA 1968;206:830-832.
    • (1968) JAMA , vol.206 , pp. 830-832
    • Tassel, D.1    Madoff, M.A.2
  • 6
    • 0023908371 scopus 로고
    • Clinical use of systemic antifungal agents
    • Benson JM, Nahata MC: Clinical use of systemic antifungal agents. Clin Pharm 1988;7:424-438.
    • (1988) Clin Pharm , vol.7 , pp. 424-438
    • Benson, J.M.1    Nahata, M.C.2
  • 7
    • 0020691284 scopus 로고
    • Antifungal agents used in systemic mycoses. Activity and therapeutic use
    • Graybill JR, Craven PC: Antifungal agents used in systemic mycoses. Activity and therapeutic use. Drugs 1983;25:41-62.
    • (1983) Drugs , vol.25 , pp. 41-62
    • Graybill, J.R.1    Craven, P.C.2
  • 9
    • 0026564314 scopus 로고
    • Evolving role of flucytosine in immunocompromised patients: New insights into safety, pharmacokinetics, and anti-fungal therapy
    • Francis P, Walsh TJ: Evolving role of flucytosine in immunocompromised patients: New insights into safety, pharmacokinetics, and anti-fungal therapy. Clin Infect Dis 1992;15:1003-1018.
    • (1992) Clin Infect Dis , vol.15 , pp. 1003-1018
    • Francis, P.1    Walsh, T.J.2
  • 10
  • 13
    • 0001902681 scopus 로고    scopus 로고
    • Antimicrobial agents. Antifungal agents
    • Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Goodman Gilman A (eds). New York, McGraw-Hill
    • Bennett JE: Antimicrobial agents. Antifungal agents; in Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Goodman Gilman A (eds): Goodman & Gilman's The Pharmacological Basis of Therapeutics. New York, McGraw-Hill, 1996, pp 1175-1190.
    • (1996) Goodman & Gilman's The Pharmacological Basis of Therapeutics , pp. 1175-1190
    • Bennett, J.E.1
  • 14
    • 0002190941 scopus 로고
    • Flucytosine
    • Speller DCE (ed). New York, Wiley
    • Scholer HJ: Flucytosine; in Speller DCE (ed): Antifungal Chemotherapy. New York, Wiley, 1980, pp 35-106.
    • (1980) Antifungal Chemotherapy , pp. 35-106
    • Scholer, H.J.1
  • 16
    • 0016255527 scopus 로고
    • Treatment of disseminated candidiasis with 5-fluorocytosine
    • Eilard T, Alestig K, Wahlén P: Treatment of disseminated candidiasis with 5-fluorocytosine. J Infect Dis 1974;130:155-159.
    • (1974) J Infect Dis , vol.130 , pp. 155-159
    • Eilard, T.1    Alestig, K.2    Wahlén, P.3
  • 17
    • 0017349264 scopus 로고
    • Bone marrow toxicity associated with 5-fluorocytosine therapy
    • Kauffman CA, Frame PT: Bone marrow toxicity associated with 5-fluorocytosine therapy. Antimicrob Agents Chemother 1977;11:244-247.
    • (1977) Antimicrob Agents Chemother , vol.11 , pp. 244-247
    • Kauffman, C.A.1    Frame, P.T.2
  • 20
    • 0033961388 scopus 로고    scopus 로고
    • Flucytosine: Correlation between toxicity and pharmacokinetic parameters
    • Vermes A, van der Sijs IH, Guchelaar HJ: Flucytosine: Correlation between toxicity and pharmacokinetic parameters. Chemotherapy 2000;46:86-94.
    • (2000) Chemotherapy , vol.46 , pp. 86-94
    • Vermes, A.1    Van Der Sijs, I.H.2    Guchelaar, H.J.3
  • 21
    • 0018080634 scopus 로고
    • Evidence for conversion of 5-fluorocytosine to 5-fluorouracil in humans: Possible factor in 5-fluorocytosine clinical toxicity
    • Diasio RB, Lakings DE, Bennett JE: Evidence for conversion of 5-fluorocytosine to 5-fluorouracil in humans: Possible factor in 5-fluorocytosine clinical toxicity. Antimicrob Agents Chemother 1978;14:903-908.
    • (1978) Antimicrob Agents Chemother , vol.14 , pp. 903-908
    • Diasio, R.B.1    Lakings, D.E.2    Bennett, J.E.3
  • 23
    • 0025729771 scopus 로고
    • Flucytosine conversion to fluorouracil in humans: Does a correlation with gut flora status exist? A report of two cases using fluorine-19 magnetic resonance spectroscopy
    • Malet-Martino MC, Martino R, de Forni M, Andremont A, Hartmann O, Armand JP: Flucytosine conversion to fluorouracil in humans: Does a correlation with gut flora status exist? A report of two cases using fluorine-19 magnetic resonance spectroscopy. Infection 1991;19:178-180.
    • (1991) Infection , vol.19 , pp. 178-180
    • Malet-Martino, M.C.1    Martino, R.2    De Forni, M.3    Andremont, A.4    Hartmann, O.5    Armand, J.P.6
  • 24
    • 0023501122 scopus 로고
    • Direct detection of new flucytosine metabolites in human biofluids by 19F nuclear magnetic resonance
    • Vialaneix JP, Malet-Martino MC, Hoffmann JC, Pris J, Martino R: Direct detection of new flucytosine metabolites in human biofluids by 19F nuclear magnetic resonance. Drug Metab Dispos 1987;15:718-724.
    • (1987) Drug Metab Dispos , vol.15 , pp. 718-724
    • Vialaneix, J.P.1    Malet-Martino, M.C.2    Hoffmann, J.C.3    Pris, J.4    Martino, R.5
  • 25
    • 0019870367 scopus 로고
    • Identification of minor metabolites of 5-fluorocytosine in man by chemical ionization gas chromatography mass spectrometry
    • Williams KM, Duffield AM, Christopher RK, Finlayson OJ: Identification of minor metabolites of 5-fluorocytosine in man by chemical ionization gas chromatography mass spectrometry. Biomed Mass Spectrom 1981;8:179-182.
    • (1981) Biomed Mass Spectrom , vol.8 , pp. 179-182
    • Williams, K.M.1    Duffield, A.M.2    Christopher, R.K.3    Finlayson, O.J.4
  • 26
    • 0344109583 scopus 로고    scopus 로고
    • Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
    • Meta-Analysis Group in Cancer
    • Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. Meta-Analysis Group in Cancer. J Clin Oncol 1998;16:301-308.
    • (1998) J Clin Oncol , vol.16 , pp. 301-308
  • 27
    • 0345596364 scopus 로고    scopus 로고
    • Toxicity of fluorouracil compared in patients with advanced colorectal cancer: Effect of administration schedule and prognostic factors
    • Meta-Analysis Group in Cancer
    • Toxicity of fluorouracil compared in patients with advanced colorectal cancer: Effect of administration schedule and prognostic factors. Meta-Analysis Group in Cancer. J Clin Oncol 1998;16:3537-3541.
    • (1998) J Clin Oncol , vol.16 , pp. 3537-3541
  • 28
    • 0032961161 scopus 로고    scopus 로고
    • An accelerated stability study of 5-flucytosine in intravenous solution
    • Vermes A, van der Sijs IH, Guchelaar HJ: An accelerated stability study of 5-flucytosine in intravenous solution. Pharm World Sci 1999;21:35-39.
    • (1999) Pharm World Sci , vol.21 , pp. 35-39
    • Vermes, A.1    Van Der Sijs, I.H.2    Guchelaar, H.J.3
  • 29
    • 0035062532 scopus 로고    scopus 로고
    • Simultaneous determination of flucytosine and fluorouracil in human plasma by high-performance liquid chromatography
    • Sastre Toraño J, Vermes A, Guchelaar HJ: Simultaneous determination of flucytosine and fluorouracil in human plasma by high-performance liquid chromatography. Biomed Chromatogr 2001;15:89-94.
    • (2001) Biomed Chromatogr , vol.15 , pp. 89-94
    • Sastre Toraño, J.1    Vermes, A.2    Guchelaar, H.J.3
  • 31
    • 0033485453 scopus 로고    scopus 로고
    • Noval oral fluoropyrimidines in the treatment of metastatic colorectal cancer
    • Ignoffo RJ: Noval oral fluoropyrimidines in the treatment of metastatic colorectal cancer. Am J Health Syst Pharm 1999;56:2417-2430.
    • (1999) Am J Health Syst Pharm , vol.56 , pp. 2417-2430
    • Ignoffo, R.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.