Brca2 (XRCC11) deficiency results in enhanced mutagenesis

Mutagenesis

Volumn 18, Issue 6, 2003, Pages 521-525

  Kraakman van der Zwet, Maria ^a   Wiegant, Wouter W ^a   Zdzienicka, Małgorzata Z ^a,b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NICOLAUS COPERNICUS UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA2 PROTEIN; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

ANIMAL CELL; ARTICLE; BREAST CANCER; CELL MUTANT; CELL STRAIN; CHINESE HAMSTER; CONTROLLED STUDY; DATA ANALYSIS; FREQUENCY ANALYSIS; GENE LOCUS; IONIZING RADIATION; MUTAGENESIS; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; RADIATION DOSE; RADIATION EXPOSURE; RISK ASSESSMENT; SPONTANEOUS MUTATION; WILD TYPE;

ANIMALS; BRCA2 PROTEIN; CHO CELLS; CRICETINAE; CRICETULUS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MUTAGENESIS; MUTATION; RADIATION, IONIZING;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0344897741     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/geg032     Document Type: Article

References (33)

1. Abbott,D.W., Freeman,M.L. and Holt,J.T. (1998) Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells. J. Natl Cancer Inst., 90, 978-985.
2. Alter,B.P. (1996) Fanconi's anemia and malignancies. Am. J. Hematol., 53, 99-110.
3. Collins,N., McManus,R., Wooster,R. et al. (1995) Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13. Oncogene, 10, 1673-1675.
4. Cornelis,R.S., Neuhausen,S.L., Johansson,O. et al. (1995) High allele loss rates at 17q12-q21 in breast and ovarian tumors from BRCA1-linked families. The Breast Cancer Linkage Consortium. Genes Chromosomes Cancer, 13, 203-210.
5. Dronkert,M.L. and Kanaar,R. (2001) Repair of DNA interstrand cross-links. Mutat. Res., 486, 217-247.
6. Escarceller,M., Rousset,S., Moustacchi,E. and Papadopoulo,D. (1997) The fidelity of double strand breaks processing is impaired in complementation groups B and D of Fanconi anemia, a genetic instability syndrome. Somat. Cell Mol. Genet., 23, 401-411.
7. Grompe,M. and D'Andrea,A. (2001) Fanconi anemia and DNA repair. Hum. Mol. Genet., 10, 2253-2259.
8. Howlett,N.G., Taniguchi, T., Olson,S. et al. (2002) Biallelic inactivation of BRCA2 in Fanconi anemia. Science, 297, 606-609.
9. Kraakman-van der Zwet,M., Overkamp,W.J., van Lange,R.E. et al. (2002) Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions. Mol. Cell. Biol., 22, 669-679.
10. Larminat,F., Germanier,M., Papouli,E. and Defais,M. (2002) Deficiency in BRCA2 leads to increase in non-conservative homologous recombination. Oncogene, 21, 5188-5192.
11. Lengauer,C., Kinzler,K.W. and Vogelstein,B. (1998) Genetic instabilities in human cancers. Nature, 396, 643-649.
12. Loeb,L.A. (2001) A mutator phenotype in cancer. Cancer Res., 61, 3230-3239.
13. Moynahan,M.E., Pierce,A.J. and Jasin,M. (2001) BRCA2 is required for homology-directed repair of chromosomal breaks. Mol. Cell, 7, 263-272.
14. Overkamp,W.J., Rooimans,M.A., Neuteboom,I., Telleman,P., Arwert,F. and Zdzienicka,M.Z. (1993) Genetic diversity of mitomycin C-hypersensitive Chinese hamster cell mutants: a new complementation group with chromosomal instability. Somat. Cell Mol. Genet., 19, 431-437.
15. Papadopoulo,D., Guillouf,C., Mohrenweiser,H. and Moustacchi,E. (1990) Hypomutability in Fanconi anemia cells is associated with increased deletion frequency at the HPRT locus. Proc. Natl Acad. Sci. USA, 87, 8383-8387
16. Pellegrini,L., Yu,D.S., Lo,T., Anand,S., Lee,M., Blundell,T.L. and Venkitaraman,A.R. (2002) Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. Nature, 420, 287-293.
17. Powell,S.N., Willers,H. and Xia,F. (2002) BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer? Mol. Cell, 10, 1262-1263.
18. Sharan,S.K., Morimatsu,M., Albrecht,U. et al. (1997) Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature, 386, 804-810.
19. Smith,J., Andrau,J.C., Kallenbach,S., Laquerbe,A., Doyen,N. and Papadopoulo,D. (1998) Abnormal rearrangements associated with V(D)J recombination in Fanconi anemia. J. Mol. Biol., 281, 815-825.
20. Tavtigian,S.V., Simard,J., Rommens,J. et al. (1996) The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nature Genet., 12, 333-337.
21. The Breast Cancer Linkage Consortium (1999) Cancer risks in BRCA2 mutation carriers. J. Natl Cancer Inst., 91, 1310-1316.
22. Thompson,L.H. and Schild,D. (2001) Homologous recombinational repair of DNA ensures mammalian chromosome stability. Mutat. Res., 477, 131-153.
23. Tutt,A., Bertwistle,D., Valentine,J., Gabriel,A., Swift,S., Ross,G.,Griffin,C., Thacker,J. and Ashworth,A. (2001) Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences. EMBO J., 20, 4704-4716.
24. Tutt,A., Gabriel,A, Bertwistle,D., Connor,F., Paterson,H., Peacock,J.,Ross,G. and Ashworth,A. (1999) Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification. Curr. Biol., 9, 1107-1110.
25. Tutt,A.N., van Oostrom,C.T., Ross,G.M., van Steeg,H. and Ashworth,A. (2002) Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation. EMBO Rep., 3, 255-260.
26. Venkitaraman,A.R. (2002) Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell, 108, 171-182.
27. Verhaegh,G.W., Jongmans,W., Morolli,B., Jaspers,N.G., van der Schans,G.P., Lohman,P.H. and Zdzienicka,M.Z. (1995) A novel type of X-ray-sensitive Chinese hamster cell mutant with radioresistant DNA synthesis and hampered DNA double-strand break repair. Mutat. Res., 337, 119-129.
28. Wong,A.K.C., Pero,R., Ormonde,P.A., Tavtigian,S.V. and Bartel,P.L. (1997) RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2. J. Biol. Chem., 272, 31941-31944.
29. Xia,F., Taghian,D.G., DeFrank,J.S., Zeng,Z.C., Willers,H., Iliakis,G. and Powell,S.N. (2001) Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining. Proc. Natl Acad. Sci. USA, 98, 8644-8649.
30. Yang,H., Jeffrey,P.D., Miller,J. et al. (2002) BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science, 297, 1837-1848.
31. Yu,V.P., Koehler,M., Steinlein,C., Schmid,M., Hanakahi,L.A.. van Gool,A.J., West,S.C. and Venkitaraman,A.R. (2000) Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation. Genes Dev., 14, 1400-1406.
32. Zdzienicka,M.Z. and Simons,J.W. (1987) Mutagen-sensitive cell lines are obtained with a high frequency in V79 Chinese hamster cells. Mutat. Res., 178, 235-244.
33. Zhang,L.H., Vrieling,H., van Zeeland,A.A. and Jenssen,D. (1992) Spectrum of spontaneously occurring mutations in the hprt gene of V79 Chinese hamster cells. J. Mol. Biol., 223, 627-635.