Species and gender differences in the metabolism and distribution of tertiary amyl methyl ether in male and female rats and mice after inhalation exposure or gavage administration

Journal of Applied Toxicology

Volumn 23, Issue 6, 2003, Pages 427-436

  Sumner, Susan C J ^a,b   Janszen, Derek B ^a,c   Asgharian, Bahman ^a   Moore, Timothy A ^a,d   Parkinson, Horace D ^a   Fennell, Timothy R ^a,e  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b Clinical Data Inc   (United States)

^c PFIZER INC   (United States)

^d Deloitte and Touche   (United States)

^e RTI INTERNATIONAL   (United States)

Author keywords

Distribution; Gavage; Inhalation; Metabolism; Tertiary amyl methyl ether

Indexed keywords

2 METHOXY 2 METHYLBUTANE; ALCOHOL DERIVATIVE; ALKANE DERIVATIVE; CARBON 14; CYTOCHROME P450; ETHER DERIVATIVE; UNCLASSIFIED DRUG; VOLATILE ORGANIC COMPOUND;

ANIMAL EXPERIMENT; ARTICLE; CONJUGATION; CONTROLLED STUDY; EXPIRED AIR; EXPOSURE; FECES LEVEL; FEEDING; FEMALE; INHALATION; ISOTOPE LABELING; LETHAL DOSE; MALE; METABOLISM; METABOLITE; MOUSE; MOUSE STRAIN; NONHUMAN; OXIDATION KINETICS; PRIORITY JOURNAL; RADIOACTIVITY; RAT; RAT STRAIN; SEX DIFFERENCE; SPECIES DIFFERENCE; TISSUE DISTRIBUTION; TOXICOKINETICS; URINARY EXCRETION;

ADMINISTRATION, ORAL; AIR POLLUTANTS; ANIMALS; CARBON DIOXIDE; CARBON RADIOISOTOPES; FECES; FEMALE; INHALATION EXPOSURE; MALE; METHYL ETHERS; MICE; PENTANOLS; RATS; SEX FACTORS; SPECIES SPECIFICITY; TISSUE DISTRIBUTION;

TRIXIS;

EID: 0344897226     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jat.931     Document Type: Article

References (12)

1. Arms AD, Travis CC. 1988. Reference Physiological Parameters in Pharmacokinetic modelling, EPA Report 600/6-88/004. Washington DC.
2. 13C nuclear magnetic resonance and gas chromatography/mass spectroscopy. Chem. Res. Toxicol. 11: 651-658.
3. Hong J-Y, Yang CS, Lee M, Wang Y-Y, Huang W-Q, Tan Y, Paten CJ, Bondoc FY. 1997. Role of cytochromes P450 in the metabolism of methyl tert-butyl ether in human livers. Arch. Toxicol. 71: 266-269.
4. Hong J-Y, Wang Y-Y, Bondoc FY, Yang CS, Gonzalez FJ, Pan Z, Cokonis C-D, Hu W-Y, Bao Z. 1999. Metabolism of methyl tert-butyl ether and other gasoline ethers in mouse liver microsomes lacking cytochrome P450 2E1. Toxicol. Lett. 105: 83-88.
5. Miller MJ, Ferdinandi ES, Klan M, Andrews LS, Douglas JF, Kneiss JJ. 1997. Pharmacokinetics and disposition of methyl t-butyl ether in Fischer-344 rats. J. Appl. Toxicol. 17: S3-S12.
6. 2-MTBE): toxicokinetics and characterization of urinary metabolites in humans. Chem. Res. Toxicol. 12: 822-830.
7. Sumner SCJ, Asgharian B, Moore TA, Parkinson HD, Bobbitt CM, Fennell TR. 2003a. Characterization of metabolites and disposition of tertiary amyl methyl ether in male F344 rats following inhalation exposure. J. Appl. Toxicol. 23: 411-417.
8. Sumner SCJ, Janszen DB, Asgharian B, Moore TA, Bobbitt CM, Fennell TR. 2003b. Blood pharmacokinetics of tertiary amyl methyl ether in male and remale F344 rats and CD-1 mice after nose-only inhalation exposure. J. Appl. Toxicol. 23: 419-425.
9. Turini A, Amato G, Longo V, Gervasi PG. 1998. Oxidation of methyl- and ethyl-tertiary-butyl ethers in rat liver microsomes: role of the cytochrome P450 isoforms. Arch. Toxicol. 72: 207-214.
10. Tyl RW, Myers, CB, Marr MC, Fail PA, Seely JC, Elswick BA, James RA, Welsch, F. 2003. Two-generation reproductive toxicity study of inhaled tertiary amyl methyl ether (TAME) vapor in CD® rats. J. Appl. Toxicol. 23: 397-410.
11. US Environmental Protection Agency (US EPA). 1995. Testing consent order for tertiary amyl methyl ether. Fed. Reg. 60: 14910-14911.
12. Welsch F, Elswick B, James RA, Marr MC, Myers CB, Tyl RW. 2003. Developmental toxicity evaluation of inhaled tertiary amyl methyl ether in mice and rats. J. Appl. Toxicol. 23: 387-395.