A Cyclic CCK8 Analogue Selective for the Cholecystokinin Type A Receptor: Design, Synthesis, NMR Structure and Binding Measurements

ChemBioChem

Volumn 4, Issue 11, 2003, Pages 1176-1187

  De Luca, Stefania ^a   Ragone, Raffaele ^b   Bracco, Chiara ^c   Digilio, Giuseppe ^c   Aloj, Luigi ^a   Tesauro, Diego ^a   Saviano, Michele ^a   Pedone, Carlo ^a   Morelli, Giancarlo ^a  

^a CNR   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c Bioindustry Park del Canavese   (Italy)

Author keywords

Binding studies; CCK analogues; Conformation analysis; Cyclic peptides; Ligand design

Indexed keywords

CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ DERIVATIVE; CYCLOPEPTIDE; DODECYLPHOSPHORYLCHOLINE; LYSINE; METHIONINE; TRYPTOPHAN; WATER;

AMINO TERMINAL SEQUENCE; AQUEOUS SOLUTION; ARTICLE; ATOM; CARBOXY TERMINAL SEQUENCE; CONFORMATION; DISSOCIATION CONSTANT; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; MICELLE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RECEPTOR BINDING; SPATIAL ORIENTATION;

CELLS, CULTURED; DRUG DESIGN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTOR, CHOLECYSTOKININ A;

EID: 0344875561     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200300635     Document Type: Article

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