Responsiveness of Dupuytren's Disease Fibroblasts to 5α -Dihydrotestosterone

Journal of Hand Surgery

Volumn 28, Issue 6, 2003, Pages 1029-1034

  Pagnotta, Alessia ^a   Specchia, Nicola ^a   Soccetti, Andrea ^a   Manzotti, Sandra ^a   Greco, Francesco ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

5 DHT; Androgen receptor; Dupuytren's contracture; Myofibroblast

Indexed keywords

ALPHA ACTIN; ANDROGEN RECEPTOR; ANDROSTANOLONE; TESTOSTERONE DERIVATIVE;

ADULT; AGED; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EXPOSURE; DRUG RESPONSE; DUPUYTREN CONTRACTURE; FASCIA; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; PATIENT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE;

EID: 0344873154     PISSN: 03635023     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0363-5023(03)00429-5     Document Type: Article

References (20)

1. Wilbrand S, Ekbom A, Gerdin B. The sex ratio and rate of reoperation for Dupuytren's contracture in men and women. J Hand Surg 1999;24B:456-459.
2. Gabbiani G, Majno G. Dupuytren's contracture: fibroblast contraction? An ultrastructural study. Am J Pathol 1972;66: 131-146.
3. Shum DT, McFarlane RM. Histogenesis of Dupuytren's disease: an immunohistochemical study of 30 cases. J Hand Surg 1988;13A:61-67.
4. Halliday NL, Rayan GM, Zardi L, Tomasek JJ. Distribution of ED-A and ED-B containing fibronectin isoforms in Dupuytren's disease. J Hand Surg 1994;19A:428-434.
5. Baird KS, Crossan JF, Ralston SH. Abnormal growth factor and cytokine expression in Dupuytren's contracture. J Clin Pathol 1993;46:425-428.
6. Gonzalez A-M, Buscaglia M, Fox R, Isacchi A, Sarmientos P, Farris J, et al. Basic fibroblast growth factor in Dupuytren's contracture. Am J Pathol 1992;141:661-671.
7. Pagnotta A, Specchia N, Greco F. Androgen receptors in Dupuytren's contracture. J Orthop Res 2002;20;163-168.
8. Schmidt JB, Spona J, Huber J. Androgen receptor in hirsutism and acne. Gynecol Obstet Invest 1986;22:206-211.
9. Michel G, Baulieu EE. Androgen receptor in rat skeletal muscle: characterization and physiological variations. Endocrinology 1980;107:2088-2098.
10. Gerdes MJ, Dang TD, Lu B, Larsen M, McBride L, Rowley DR. Androgen-regulated proliferation and gene transcription in a prostate smooth muscle cell line (PS-1). Endocrinology 1996;137:864-872.
11. Lubahn DB, Joseph DR, Sullivan PM, Willard HF, French FS, Wilson EM. Cloning of human androgen receptor complementary DNA and location to the X chromosome. Science 1988;240:327-330.
12. Hamlet WP, Liu SH, Panossian V, Finerman GAM. Primary immunolocalization of androgen target cells in the human anterior cruciate ligament. J Orthop Res 1997;15: 657-663.
13. Doumit ME, Cook DR, Merkel RA. Testosterone up-regulates androgen receptors and decreases differentiation of porcine myogenic satellite cells in vitro. J Endocrinol 1996; 137:1385-1394.
14. Tubiana R. Dupuytren's disease of the radial side of the hand. Hand Clin 1999;15:149-159.
15. Zegers ND, Claassen E, Neelen C, Mulder E, van Laar JH, Voorhorst MM, et al. Epitope prediction and confirmation for the human androgen receptor: generation of monoclonal antibodies for multi-assay performance following the synthetic peptide strategy. Biochim Biophys Acta 1991;1073:23-32.
16. Tomasek J, Rayan GM. Correlation of α-smooth muscle actin expression and contraction in Dupuytren's disease fibroblasts. J Hand Surg 1995;20A:450-455.
17. Schlatt S, Weinbauer GF, Arslan M, Nieschlag E. Appearance of α-smooth muscle actin in peritubular cells of monkey testes is induced by androgens, modulated by follicle-stimulating hormone, and maintained after hormonal withdrawal. J Androl 1993;14:340-350.
18. Liao S. Androgen action: molecular mechanism and medical application. J Formos Med Assoc 1994;93:741-751.
19. Ricciardelli C, Horsfall DJ, Sykes PJ, Marshall VR, Tilley WD. Effect of oestradiol-17β and 5α-dihydrotestosterone on guinea-pig prostate smooth muscle cell proliferation and steroid receptor expression in vitro. J Endocrinol 1994;140: 373-383.
20. Schmidt JB. Other antiandrogens. Dermatology 1998;196: 153-157.