The FAR proteins of parasitic nematodes: Their possible involvement in the pathogenesis of infection and the use of Caenorhabditis elegans as a model system to evaluate their function

Medical Microbiology and Immunology

Volumn 192, Issue 1, 2003, Pages 47-52

  Garofalo, Antonio ^a   Kennedy, Malcolm W ^b   Bradley, Janette E ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Caenorhabditis elegans; FAR proteins; Fatty acids; Parasitic nematodes; Retinol

Indexed keywords

FAR PROTEIN; FATTY ACID; FATTY ACID BINDING PROTEIN; LIPID; RETINOID; RETINOL BINDING PROTEIN; SCAVENGER; UNCLASSIFIED DRUG;

CAENORHABDITIS ELEGANS; CONFERENCE PAPER; GENETICS; GENOME; HOST PARASITE INTERACTION; IMMUNE RESPONSE; IMMUNOMODULATION; MODEL; NEMATODE; NEMATODIASIS; PARASITE DEVELOPMENT; PARASITE SURVIVAL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN SECRETION;

EID: 0344837390     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00430-002-0158-6     Document Type: Conference Paper

References (52)

1. Banaszak L, Winter N, Xu Z, Bernlohr DA, Cowan S, Jones TA (1994) Lipid-binding proteins: a family of fatty acid and retinoid transport proteins. Adv Protein Chem 45:89-151
2. Blaxter M (1998) Caenorhabditis elegans is a nematode. Science 282:2041-2103
3. Bradley JE, Helm R, Lahaise M, Maizels RM (1991) cDNA clones of Onchocerca volvulus low molecular weight antigens provide immunologically specific diagnostic probes. Mol Biochem Parasitol 46:219-228
4. Bradley JE, Nirmalan NJ, Klager SL, Faulkner H, Kennedy MW (2001) River blindness: a role for parasite retinoid-binding proteins in the generation of pathology? Trends Parasitol 17:471-475
5. Brownlie P, Ceska T, Lamers M, Romier C, Stier G, Teo H, Suck D (1997) The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control. Structure 15:509-520
6. Buelt MK, Xu Z, Banaszak LJ, Bernlohr DA (1992) Structural and functional characterisation of the phosphorylated adipocyte lipid-binding protein (pp 15). Biochemistry 31:3493-3499
7. Burglin TR, Lobos E, Blaxter ML (1998) Caenorhabditis elegans as a model for parasitic nematodes. Int J Parasitol 28:395-411
8. Burkhard P, Stetfeld J, Strelkov SV (2001) Coiled-coils: a highly versatile protein folding motif. Trends Cell Biol 11:82-88
9. Buttner DW, Albiez EJ, von Essen J, Erichsen J (1988) Histological examination of Onchocerca volvulus and comparison with the collagenase technique. Trop Med Parasitol 39:390-417
10. Cantorna MT, Nashold FE, Chun TY, Hayes CE (1994) In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess Th1 and insufficient Th2 function. J Immunol 152:1515-1522
11. Cantorna MT, Nashold FE, Chun TY, Hayes CE (1996) Vitamin A down-regulation of IFN-gamma synthesis in cloned mouse Th1 lymphocytes depends on the CD28 costimulatory pathway. J Immunol 156:2674-2679
12. C. elegans Sequencing Consortium (1998) Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282:2012-2018
13. Comley JCW, Jaffe JJ (1983) The conversion of exogenous retinol and related compounds into retinyl phosphate mannose by adult Brugi pahangi in vitro. Biochem J 214:367-376
14. Cowan SW, Newcomer ME, Jones TA (1993) Crystallographic studies on a family of cellular lipophilic transport proteins. Refinement of P2 myelin protein and the structure determination and refinement of cellular retinol-binding protein in complex with all-trans-retinol. J Mol Biol 230:1225-1246
15. Flower DR (1996) The lipocalin protein family: structure and function. Biochem J 318:1-14
16. Ganjeizadeh M, Zolotarjova N, Huang WH, Askari A (1995) Interactions of phosphorylation and dimerizing domains of the alpha subunits of Na (+)/K (+)-ATPase. J Biol Chem 270:15707-15710
17. Garofalo A, Kläger SL, Rowlinson MC, Nirmalan N, Klion A, Allen JE, Kennedy MW, Bradley JE (2002) The FAR proteins of filarial nematodes: secretion, glycosylation and lipid binding characteristics. Mol Biochem Parasitol 122:161-170
18. Gudas LJ, Sporn MB, Roberts A (1994) Celluar biology and biochemistry of retinoids. In: Sporn MB, Roberts AB, Goodman DS (eds) The retinoids. Raven, New York, pp 443-520
19. Hashmi S, TaweW, Lustigman S (2001) Caenorhabditis elegans and the study of gene function in parasites. Trends Parasitol 17:387-393
20. Kennedy MW (2000) The nematode polyprotein allergens/antigens. Parasitol Today 16:373-380
21. Kennedy MW (2000) The polyprotein lipid binding proteins of nematodes. Biochim Biophys Acta 1476:149-164
22. Kennedy MW, Allen JE, Wright AS, McCruden AB, Cooper A (1995) The gp15/400 polyprotein antigen of Brugia malayi binds fatty acids and retinoids. Mol Biochem Parasitol 71:41-50
23. Kennedy MW, Brass A, McCruden AB, Price NC, Kelly SM, Cooper A (1995) The ABA-1 allergen of the parasitic nematode Ascaris suum: fatty acid and retinoid binding function and structural characterisation. Biochemistry 34:6700-6710
24. Kennedy MW, Britton C, Price NC, Kelly SM, Cooper A (1995) The DvA-1 polyprotein of the parasitic nematode Dictyocaulus viviparus: a small helix-rich lipid-binding protein. J Biol Chem 270:19277-19281
25. Kennedy MW, Garside LH, Goodrick LE, McDermott L, Brass A, Price NC, Kelly SM, Cooper A, Bradley JE (1997) The Ov20 Protein of the Parasitic Nematode Onchocerca volvulus. J Biol Chem 272:29442-29448
26. Lal PG, James ER (1996) Onchocerca retinol-and-ivermectin-binding protein. Parasitology 112:221-225
27. Liu LX, Buhlmann JE, Weller PF (1992) Release of prostaglandin-E2 by microfilarae of Wucheria bancrofti and Brugia malayi. Am J Trop Med Hyg 46:520-523
28. Lok JB, Morris RA, Sani BP, Shealy YF, Donelly JJ (1990) Synthetic and naturally occurring retinoids inhibit third to fourth stage larval development by Onchocerca lienalis in vitro. Trop Med Parasitol 41:169-173
29. Moore J, Mcdermott L, Price NC, Kelly SM, Cooper A? Kennedy MW (1999) Sequence divergent units of the ABA-1 polyprotein array of the nematode Ascaris have similar fatty acid and retinol binding properties but different binding site environments. Biochem J 340:337-343
30. Nirmalan NJ (1999) A comparative analysis of novel filarial retinol binding proteins. Thesis, University of Salford
31. Nirmalan NJ, Cordeiro NJV, Klager SL, Bradley JE and Allen JE (1999) Comparative analysis of glycosylated and non-glycosylated filarial homologues of the 20-kilodalton retinol binding protein from Onchocerca volvulus (Ov20). Infect Immun 67:6329-6334
32. Noy N (2000) Retinoid-binding proteins: mediators of retinoid action. Biochem J 348:481-495
33. Olson JK, Bishop GA, Grose C (1997) Varicella-zoster virus Fc receptor gE glycoprotein: serine/threonine and tyrosine phosphorylation of monomeric and dimeric forms. J Virol 71:110-119
34. Prior A, Jones JT, Blok VC, Beauchamp J, Mcdermott L, CooperA, Kennedy MW (2001) A surface-associated retinol and fatty acid binding protein (Gp-FAR-1) from the potato cyst nematode Globodera pallida: lipid binding activities, structural analysis and expression pattern. Biochem J 356:387-394
35. Sani BP, Comley JCW (1985) Role of retinoids and their binding proteins in filarial parasites and host tissues. Trop Med Parasitol 36:20-23
36. Sani BP, Vaid A (1988) Specific interaction of ivermectin with retinol-binding proteins from filarial nematodes. Biochem J 249:929-932
37. Sani BP, Vaid A, Comley JCW, Montgomery JA (1985) Novel retinoid-binding proteins from filarial parasites. Biochem J 232:577-583
38. Schulz-Key H (1988) The collagenase technique: how to isolate and examine adult Onchocerca volvulus for the evaluation of drug effects. Trop Med Parasitol 39:423-440
39. Semba RD, Ward BJ, Griffin DE, Scott,AL, Natadisastra G, West KP, Sommer A (1993) Abnormal T-cell subset proportions in vitamin-A-deficient children. Lancet 341:5-8
40. Storey DM (1982) Vitamin A deficiency and the development of Litosomoides carinii (Nematoda Filaroidea) in cotton rats. Z Parasitenkd 67:309-315
41. Sturchler D, Wyss F, Hanck A (1981) Retinol, onchocerciasis and Onchocerca volvulus. Trans R Soc Trop Med Hyg 75:617-625
42. Sturchler D, Holzer B, Hanck A, Degremont A (1983) The influence on the serum concentrations of retinol and retinol binding protein of a rural population in Liberia. Acta Trop 40:261-269
43. Surette MG, Levit M, Liu Y, Lukat G, Ninfa EG, Ninfa A, Stock JB (1996) Dimerization is required for the activity of the protein histidine kinase CheA that mediates signal transduction in bacterial chemotaxis. J Biol Chem 271:939-945
44. Szilak L, Moitra J, Krylov D, Vinson C (1997) Phosphorylation destabilizes alpha-helices. Nat Struct Biol 4:112-114
45. Thumser AEA, Evans C, Worrall AF, Wilton DC (1994) Effect on ligand binding of arginine mutations in recombinant rat liver fatty acid-binding protein. Biochem J 297:103-107
46. Tree TIM, Gillespie AJ, Shepley KJ, Blaxter ML, Tuan RS, Bradley JE (1995) Characterisation of an immunodominant glycoprotein antigen of Onchocerca volvulus with homologues in other filarial nematodes and Caenorhabditis elegans. Mol Biochem Parasitol 69:185-195
47. Ventura C, Maioli M (2001) Protein kinase C control of gene expression. Crit Rev Eukaryot Gene Expr 11:243-267
48. Vogel S, Gamble MV, Blaner WS (1999) Biosynthesis, absorption, metabolism and transport of retinoids. In: Nau H, Blaner WS (eds) The biochemical and molecular basis of vitamin A and retinoid action. Springer, Berlin Heidelberg New York, pp 31-95
49. Wilkinson TCI, Wilton DC (1986) Studies on fatty acid-binding proteins. The detection and quantification of the protein from rat liver using a fluorescent fatty acid analogue. Biochem J 238:419-424
50. Wolff KM, Scott AL (1995) Brugia malayi: retinoic acid uptake and localisation. Exp Parasitol 80:282-290
51. Xia Y, Spence HJ, Moore J, Heaney N, McDermott L, Cooper A, Watson DG, Mei B, Komuniecki R, Kennedy MW (2000) The ABA-1 allergen of Ascaris lumbricoides: sequence polymorphism, stage and tissue-specific expression, lipid binding function, and protein biophysical properties. Parasitology 120:211-224
52. Zahner H, Sani BP, Shealy YF, Nitschmann A (1989) Antifilarial activities of synthetic and natural retinoids in vitro. Trop Med Parasitol 40:322-326