Accumulating mutations of p53 in colon tumor and hairy cell leukemia do not arise from methylation/deamination processes, but rather from nucleotide deletions and insertions

Biological Chemistry

Volumn 379, Issue 4-5, 1998, Pages 545-547

  Marcsek, Zoltán L ^a   König, Edwin A ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Colorectal cancer; Hairy cell leukemia; p53 mutations; Sequencing; SSCP

Indexed keywords

PRIMER DNA; PROTEIN P53;

COLON POLYP; COLORECTAL CARCINOMA; CONFERENCE PAPER; DEAMINATION; DNA METHYLATION; HAIRY CELL LEUKEMIA; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; STOMACH CARCINOMA; TUMOR SUPPRESSOR GENE;

COLONIC POLYPS; COLORECTAL NEOPLASMS; DEAMINATION; DNA METHYLATION; GENES, P53; HUMANS; LEUKEMIA, HAIRY CELL; MUTAGENESIS, INSERTIONAL; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; SEQUENCE DELETION; STOMACH NEOPLASMS;

EID: 0344835887     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (8)

1. Baldini, L., Fracchiolla, N.S., Cro, L.M., Trecca, D., Romitti, L., Polli, E., Maiolo, A.T., and Neri, A. (1994). Frequent p53 gene involvement in splenic B-cell leukemia/lymphomas of possible marginal zone origin. Blood 84, 270-278.
2. Grigg, G., and Clark, S. (1994). Sequencing 5-methylcytosine residues in genomic DNA. Bioessays 16, 431-436.
3. Facher, E.A., Becich, M.J., Deka, A., and Law, J.C. (1997). Association between human cancer and two polymorphisms occurring together in the p21 Waf1/Cip1 cyclin-dependent kinase inhibitor gene. Cancer 79, 2424-2429.
4. Jackson-Grusby, L., and Jaenisch, R. (1996). Experimental manipulation of genomic methylation. Semin. Cancer Biol. 7, 261-268.
5. Schmutte, C., Yang, A.S., Nguyen, T.T., Beart, R.W., and Jones, P.A. (1996). Mechanisms for the involvement of DNA methylation in colon carcinogenesis. Cancer Res. 56, 2375-2381.
6. Shivapurkar, N., Huang, L., Ruggeri, B., Swalsky, P.A., Bakker, A., Finkelstein, S., Frost, A., and Silverberg, S. (1997). K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients. Cancer Lett. 115, 39-46.
7. Vogelstein, B., and Kinzler, K.W. (1993). The multistep nature of cancer. Trends Genet. 9, 138-141.
8. Yamaguchi, K., Sugano, K., Fukayama, N., Nakashima, Y., Saotome, K., Yokoyama, T., Yokota, T., and Ohkura, H. (1997). Polymerase chain reaction-based approaches for detection of allelic loss in the p53 tumor suppressor gene in colon neoplasms. Am. J. Gastroenterol. 92, 307-312.