Signal transduction and development of drug for brain ischemic insult

Folia Pharmacologica Japonica

Volumn 122, Issue SUPPL. 1, 2003, Pages

  Fukunaga, Kohji ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FAS LIGAND; FORKHEAD TRANSCRIPTION FACTOR; ORTHOVANADIC ACID; PROTEIN KINASE B; SERINE DERIVATIVE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WORTMANNIN;

ARTICLE; BRAIN ISCHEMIA; CORRELATION ANALYSIS; DEPHOSPHORYLATION; ENZYME INHIBITION; FOREBRAIN; HIPPOCAMPUS; INHIBITION KINETICS; NERVE CELL NECROSIS; NEUROPROTECTION; PHARMACOLOGICAL BLOCKING; PHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN ISCHEMIA; GERBILLINAE; NEUROPROTECTIVE AGENTS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; VANADATES;

EID: 0344825848     PISSN: 00155691     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Kawano T, Fukunaga K, Takeuchi Y, et al. Neuroprotective effects of sodium orthovanadate on delayed neuronal death after transient forebrain ischemia in gerbil hippocampus. J Cereb Blood Flow & Metab. 2001;21:1268-1280.
2. Yano S, Morioka M, Fukunaga K, et al. Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus. J Cereb Blood Flow & Metab. 2001;21:351-360.
3. Hasegawa Y, Morioka M, Yano S, et al. Neuroprotective effect of post-ischemic administration of sodium orthovanadate in rats with transient middle cerebral artery occlusion. J Cereb Blood Flow & Metab. 2003; in press.
4. Kawano T, Morioka M, Yano S, et al. Decreased Akt activity is associated with activation of forkhead transcription factor after transient forebrain ischemia in gerbil hippocampus. J Cereb Blood Flow & Metab. 2002;22:926-934.
5. Gao N, Ding M, Zheng JZ, et al. Vanadate-induced expression of hypoxia-inducible factor 1α and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species. J Biol Chem. 2002;277:31963-31971.