Hormonal-Neural Integration in the Female Rat Ventromedial Hypothalamus: Triple Labeling for Estrogen Receptor-α, Retrograde Tract Tracing from the Periaqueductal Gray, and Mating-Induced Fos Expression

Endocrinology

Volumn 144, Issue 12, 2003, Pages 5430-5440

  Calizo, Lyngine H ^a   Flanagan Cato, Loretta M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; ESTROGEN; ESTROGEN RECEPTOR ALPHA; NEUROHORMONE; PROTEIN FOS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY POSTURE; CONTROLLED STUDY; ESTROGEN RECEPTOR ALPHA IMMUNOREACTIVE NEURON; FEMALE; HORMONAL REGULATION; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IMMUNOREACTIVITY; LABELING INDEX; LORDOSIS; MATING; NERVE CELL; NERVE CONDUCTION; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SEXUAL BEHAVIOR; SIGNAL TRANSDUCTION;

ANIMALS; ESTROGEN RECEPTOR ALPHA; FEMALE; FLUORESCENT DYES; IMMUNOHISTOCHEMISTRY; NEURAL PATHWAYS; PERIAQUEDUCTAL GRAY; POSTURE; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; SEXUAL BEHAVIOR, ANIMAL; STILBAMIDINES; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 0344825811     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0331     Document Type: Article

References (55)

1. Pfaff DW 1989 Patterns of steroid hormone effects on electrical and molecular events in hypothalamic neurons. Mol Neurobiol 3:135-154
2. Rubin BS, Barfield RJ 1980 Priming of estrous responsiveness by implants of 17 β-estradiol in the ventromedial hypothalamic nucleus of female rats. Endocrinology 106:504-509
3. Carrer H, Asch G, Aron C 1973 New facts concerning the role played by the ventromedial nucleus in the control of estrous cycle duration and sexual receptivity in the rat. Neuroendocrinology 13:129-138
4. Dorner G, Docke F, Hinz G 1969 Homo-and hyper-sexuality in rats with hypothalamic lesions. Neuroendocrinology 4:20-24
5. Kennedy GC 1964 Hypothalamic control of the endocrine and behavioral changes associated with oestrus in the rat. J Physiol 172:383-392
6. Meisel RL, Dohanich GP, McEwen BS, Pfaff DW 1987 Antagonism of sexual behavior in female rats by ventromedial hypothalamic implants of antiestrogen. Neuroendocrinology 45:201-207
7. Barfield RJ, Glaser JH, Rubin BS, Etgen AM 1984 Behavioral effects of progestin in the brain. Psychoneuroendocrinology 9:217-231
8. Rubin BS, Barfield RJ 1983 Induction of estrous behavior in ovariectomized rats by sequential replacement of estrogen and progesterone to the ventromedial hypothalamus. Neuroendocrinology 37:218-224
9. Pfaff DW, Sakuma Y 1979 Facilitation of the lordosis reflex of female rats from the ventromedial nucleus of the hypothalamus. J Physiol 288:189-202
10. Hoffman GE, Murphy AZ 2000 Anatomical markers of activity in hypothalamic systems. In: Conn PM, Freeman ME, eds. Neuroendocrinology in physiology and medicine. 1st ed. Totowa, NJ: Humana Press Inc.; 541-552
11. Flanagan-Cato LM, McEwen BS 1995 Pattern of fos and jun expression in the female rat forebrain after sexual behavior. Brain Res 673:53-60
12. Tetel MJ, Getzinger MJ, Blaustein JD 1993 Fos expression in the rat brain following vaginal-cervical stimulation by mating and manual probing. J Neuroendocrinol 5:397-404
13. Yang S-P, Lee Y, Voogt JL 1999 Fos expression in the female rat brain during the proestrous prolactin surge and following mating. Neuroendocrinology 69:281-289
14. Polston EK, Erskine MS 1995 Patterns of induction of the immediate early genes c-fos and egr-1 in the female rat brain following differential amounts of mating stimulation. Neuroendocrinology 62:370-384
15. Auger AP, Moffatt CA, Blaustein JD 1996 Reproductively-relevant stimuli induce fos-immunoreactivity within progestin-containing neurons in localized regions of female rat forebrain. J Neuroendocrinol 8:831-838
16. Tetel MJ, Celentano DC, Blaustein JD 1994 Intraneuronal convergence of tactile and hormonal stimuli associated with female reproduction in rats. J Neuroendocrinol 6:211-216
17. Shughrue PJ, Lane MV, Merchenthaler I 1997 Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system. J Comp Neurol 388:507-525
18. Shughrue PJ, Merchenthaler I 2001 Distribution of estrogen receptor β immunoreactivity in the rat central nervous system. J Comp Neurol 436:64-81
19. Simerly RB, Chang C, Muramatsu M, Swanson LW 1990 Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J Comp Neurol 294:76-95
20. Pfaff D, Keiner M 1973 Atlas of estradiol-concenrrating cells in the central nervous system of the female rat. J Comp Neurol 151:121-158
21. Ogawa S, Eng V, Taylor J, Lubahn DB, Korach KS, Pfaff DW 1998 Roles of estrogen receptor-α gene expression in reproduction-related behaviors in female mice. Endocrinology 139:5070-5081
22. Ogawa S, Chan J, Chester AE, Gustafsson J-A, Korach KS, Pfaff DW 1999 Survival of reproductive behaviors in estrogen receptor β gene-deficient (βERKO) male and female mice. Proc Natl Acad Sci USA 96:12887-12892
23. Coolen LM, Peters HJPW, Veening JG 1996 Fos immunoreactivity in the rat brain following consummatory elements of sexual behavior: a sex comparison. Brain Res 738:67-82
24. Pfaus JG, Kleopoulos SP, Mobbs CV, Gibbs RB, Pfaff DW 1993 Sexual stimulation activates c-fos within estrogen-concentrating regions of the female rat forebrain. Brain Res 624:253-267
25. Tetel MJ, Getzinger MJ, Blaustein JD 1994 Estradiol and progesterone influence the response of ventromedial hypothalamic neurons to tactile stimuli associated with female reproduction. Brain Res 646:267-272
26. Canteras NS, Simerly RB, Swanson LW 1994 Organization of projections from the ventromedial nucleus of the hypothalamus: a Phaseolus vulgaris-leucoagglutinin study in the rat. J Comp Neurol 348:41-79
27. Sakuma Y, Pfaff DW 1979 Mesencephalic mechanisms for integration of female reproductive behavior in the rat. Am J Physiol 237:R285-R290
28. Akesson TR, Ulibarri C, Truitt S 1994 Divergent axon collaterals originate in the estrogen receptive ventromedial nucleus of the hypothalamus in the rat. J Neurobiol 25:406-414
29. Morrell JI, Pfaff DW 1982 Characterization of estrogen-concentrating hypothalamic neurons by their axonal projections. Science 217:1273-1276
30. Calizo LH, Flanagan-Cato LM 2002 Estrogen-induced dendritic spine elimination on female rat ventromedial hypothalamic neurons that project to the periaqueductal gray. J Comp Neurol 447:234-248
31. Daniels D, Flanagan-Cato LM 2000 Functionally-defined compartments of the lordosis neural circuit in the ventromedial hypothalamus in female rats. J Neurobiol 45:1-13
32. Bandler R, Shipley M 1994 Columnar organization in midbrain periaqueductal gray: modules for emotional expression? Trends Neurosci 17:379-389
33. Bandler R, Keay KA 1996 Columnar organization in the midbrain periaqueductal gray and the integration of emotional expression. Prog Brain Res 107: 285-300
34. Beitz AJ 1985 The midbrain periaqueductal gray in the rat. I. Nuclear volume, cell number, density, orientation, and regional subdivisions. J Comp Neurol 237:445-459
35. Lonstein JS, Stern JM 1998 Site and behavioral specificity of periaqueductal gray lesions on postpartum sexual, maternal and aggressive behaviors in rats. Brain Res 804:21-35
36. Daniels D, Miselis RR, Flanagan-Cato LM 1999 Central neuronal circuit innervating the lordosis-producing muscles defined by transneuronal transport of pseudorabies virus. J Neurosci 19:2823-2833
37. Daniels D, Miselis RR, Flanagan-Cato LM 2001 Transneuronal tracing from sympathectomized lumbar epaxial muscles in female rats. J Neurobiol 48: 278-290
38. Pfaus JG, Marcangione C, Smith WJ, Manitt C, Abillamaa H 1996 Differential induction of fos in the female rat brain following different amounts of vaginocervical stimulation: modulation by steroid hormones. Brain Res 741: 314-330
39. Flanagan LM, Pfaus JG, Pfaff DW, McEwen BS 1993 Induction of Fos immunoreactivity in oxytocin neurons after sexual activity in female rats. Neuroendocrinology 58:352-358
40. Harlan RE, Shivers BD, Kow L-M, Pfaff DW 1983 Estrogenic maintenance of lordotic responsiveness: requirement for hypothalamic action potentials. Brain Res 268:67-78
41. Pfaff DW, Sakuma Y 1979 Deficit in the lordosis reflex of female rats caused by lesions in the ventromedial nucleus of the hypothalamus. J Physiol 288: 203-210
42. Bennett AL, Blasberg ME, Blaustein JD 2001 Sensory cues mediating mating-induced potentiation of sexual receptivity in female rats. Horm Behav 40:77-83
43. Rajendren G, Dudley CA, Moss RL 1991 Role of the ventromedial nucleus of hypothalamus in the male-induced enhancement of lordosis in female rats. Physiol Behav 50:705-719
44. Calizo LH, Flanagan-Cato LM 2000 Estrogen selectively regulates spine density within the dendritic arbor of rat ventromedial hypothalamic neurons. J Neurosci 20:1589-1596
45. Bennett AL, Greco B, Blasberg ME, Blaustein JD 2002 Response to male odours in progestin receptor-and oestrogen receptor-containing cells in female rat brain. J Neuroendocrinol 14:442-449
46. Wersinger SR, Baum MJ, Erskine MS 1993 Mating-induced FOS-like immunoreactivity in the rat forebrain: a sex comparison and a dimorphic effect of pelvic nerve transection. J Neuroendocrinol 5:557-568
47. Rodriguez-Sierra JF, Crowley WR, Komisaruk BR 1975 Vaginal stimulation in rats induces prolonged lordosis responsiveness and sexual receptivity. J Comp Physiol Psychol 89:79-85
48. Yang LY, Clemens LG 1997 Function of intromissions on intromission-return latency of female rats during paced sexual behavior. Physiol Behav 61:889-894
49. Coopersmith C, Candurra C, Erskine MS 1996 Effects of paced mating and intromissive stimulation of feminine sexual behavior and estrus termination in the cycling rat. J Comp Psychol 110:176-186
50. Lodder J, Zeilmaker GH 1976 Role of pelvic nerves in the postcopulatory abbreviation of behavioral estrus in female rats. J Comp Physiol Psychol 90:925-929
51. Reading DS, Blaustein JD 1984 The relationship between heat abbreviation and neural progestin receptors in female rats. Physiol Behav 32:973-981
52. Luckman SM, Dye S, Cox HJ 1996 Induction of members of the Fos/Jun family of immediate-early genes in identified hypothalamic neurons: in vivo evidence for differential regulation. Neuroscience 73:473-485
53. Sheng HZ, Fields RD, Nelson PG 1993 Specific regulation of immediate early genes by patterned neural activity. J Neurosci Res 35:459-467
54. Luckman SM 1997 Comparison of the expression of c-fos, nur77 and egr1 mRNAs in rat hypothalamic magnocellular neurons and their putative afferent projection neurons: cell-and stimulus-specific induction. Eur J Neurosci 9:2443-2451
55. Paxinos G, Watson C 1998 The rat brain in stereotaxic coordinates. 4th ed. San Diego: Academic Press