Experimental study of the effects of maternal hyperphenylalaninemia in the central nervous system and on the behavior of offspring rats;Estudio experimental sobre los efectos de la hiperfenilalaninemia materna en el sistema nervioso central y la conducta de ratas hijas

Anales Espanoles de Pediatria

Volumn 48, Issue 1, 1998, Pages 11-16

  Garcia Vera C ^a,c   Baldellou Vazquez A ^a   Gracia Romero, J ^a   Ventura Faci, P ^b   Perez Gonzalez J ^b  

^a HOSPITAL UNIVERSITARIO MIGUEL SERVET   (Spain)

^b HOSPITAL CLÍNICO UNIVERSITARIO LOZANO BLESA   (Spain)

^c NONE   (Spain)

Author keywords

Behavior; Experimental maternal hyperphenylalaninemia; Prevention; Rats; Synaptosomes

Indexed keywords

ISOLEUCINE; LEUCINE; VALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR TERATOLOGY; BRAIN DEVELOPMENT; CONTROLLED STUDY; DEMYELINATION; DIET SUPPLEMENTATION; FERTILITY; HYPERPHENYLALANINEMIA; MICROCEPHALY; NEWBORN; NONHUMAN; PREGNANCY; RAT; SYNAPTOSOME;

AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; BRAIN; ENZYME INHIBITORS; FEMALE; FENCLONINE; MALE; PHENYLALANINE; PHENYLALANINE HYDROXYLASE; PHENYLKETONURIA, MATERNAL; PREGNANCY; RATS; RATS, WISTAR; SYNAPTOSOMES;

EID: 0344812175     PISSN: 03024342     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. DENT C. Discussion of Amstrong: relation of biochemical abnormality to development of mental defect in phenylketonuria. En: Phenylketonuria in etiological factors in mental retardation. Report of 23rd Ross Conf. Columbus. 1956.
2. Denniston JC. Children of mothers with penylketonuria. J Pediatr 1963; 63:461-462.
3. Mabry CC, Denniston JC, Goldwell JG. Mental retardation in children of phenylketonuric mothers. N Engl J Med 1966; 275:1331-1336.
4. Lenke RR, Levy HL. Maternal phenylketonuria and hyperphenylalaninemia. N Engl J Med 1980; 303:1202-1208.
5. Lipson A, Beuhler B, Bartley J y cols. Maternal hyperphenylalaninemia fetal effects. J Pediatr 1984; 104:216-220.
6. Muller WD, Haidvogl M, Scheibenreiter S. Phenylalaninfetopathie bei zwillinger einer nicht diagnosizierten phenylketonurischen mutter. Klin Padiatr 1979; 191:609-612.
7. Butcher RE. Learning impairmente associated with maternal phenylketonuria in rats. Nature 1970; 226:555-556.
8. Copenhaver JH, Vacanti JP, Carver MJ. Experimental maternal hyperphenylalaninemia: disaggregation of fetal brain ribosomes. J Neurochem 1973; 21:273-280.
9. Berry HK, Butcher RE, Kazmaier KJ, Poncet IB. Biochemical effects of induced phenylketonuria in rats. Biol Neonate 1975; 26:88-101.
10. Brunner RL, Vorhees CV, McLeans MS y cols. Beneficial effect of isoleucine on fetal brain development in induced phenylketonuria. Brain Res 1978; 154:191-195.
11. Okano Y, Chow IZ, Isshiki G y cols. Effects of phenylalanine loading on protein synthesis in the fetal heart and brain of rat: an experimental approach to maternal phenylketonuria. J Inher Metab Dis 1986; 9:15-24.
12. Brass CA, Isaacs CE, McChesney R, Greengard O. The effects of hyperphenylalaninemia on fetal development: a new animal model of maternal phenylketonuria. Pediatr Res 1982; 16:388-394.
13. Loo YH, Rabe A. Potempska A y cols. Experimental maternal phenylketonuria: An examination of two animal models. Dev Neurosci 1983/84; 6:227-234.
14. Sadava D, Sutcliffe D. The effects of maternal hyperphenylalaninemia on learning in mature rats. Life Sci 1988; 43:1119-1123.
15. Vorhees CV, Berry HK. Branched chain amino acids improve complex maxe learning in rat offspring prenatally exposed to hyperphenylalaninemia: Implications for maternal phenylketonuria. Pediatr Res 1989; 25:568-572.
16. Pueschel SM, Boylan JM, Jackson BT, Piasecki GJ. A study of placental transfer mechanisms in nonhuman primates using [14C]Phenylalanine. Obstet Gynecol 1982; 59:182-188.
17. Levy HL, Lenke RR, Koch R. Lack of fetal effect on blood phenylaline concentration in maternal phenylketonuria. Jour Pediatr 1984; 104:245-247.
18. Greengar O, Brass CA. Development changes of cerebral phenylalanine uptake from severely elevated blood levels. Neurochen Res 1987; 12:459-463.
19. McChesney R, Haberman J, Greengard O. Phenylalanine uptake in neonatal and infant rat brain. Biol Neonate 1988; 54:275-284.
20. Loo Y, Hyde K, Lin F, Wisniewski H. Cerebral biochemical abnormalities in experimental maternal phenylketonuria: gangliosides and sialoglycoproteins. Life Sci 1985; 37:2099-2109.
21. Niham MP, Douglas RL. The effect of hyperphenylalaninemia on size and density of synapses in rat neocortex. Brain Res 1979, 179:195-198.
22. Greengard O, Wolfe J. Cerebral serotonin regulation by phenylalanine analogues and during hyperphenylalaninemia. Biochem Pharmacol 1987; 36:965-970.
23. Baba H, Sato S, Inuzuka T, Miyatake T. Developmental changes of myelin-associated glycoprotein in rat brain: Study on experimental hyperphenylalaninemia. Neurochem Res 1987; 12:459-463.
24. Enriquez JA, Sánchez-Nieto J, Muiño-Blanco MT y cols. Rat brain synaptosomes prepared by phase partition. J Neurochem 1990; 55:1841-1849.
25. Bachlin H. Comportamiento y aprendizaje. Barcelona: Ediciones Omega S.A. 1982: 413-439.
26. Polidora VJ, Boggs DE, Waisman HA. A behavioral deficit associated with phenylketonuria in rats. Proc Soc Exp Biol Med 1963; 113:817-824.
27. Herrero E, Aragon MC, Giménez C, Valdivieso F. Inhibition by L-phenylalanine of tryptophan transport by synaptosomal plasma membrane vesicles: Implications in the pathogenesis of phenylketonuria. J Inher Metab Disease 1983; 6:32-35.
28. Gonatas NK, Autillo-Gambetti L, Gambetti P, Shafer B. Morphological and biochemical changes in rat synaptosome fractions during neonatal development. J Cell Biol 1971; 51:484-498.
29. Pfenninger KH, Leland E, Johnson MP y cols. Nerve growth cones isolated from fetal rat brain: Subcellular fractionation and characterization. Cell 1983; 35:573-584.
30. Gordon-Weeks PR. Lockerbie RO. Isolation and partial characterisation of neuronal growth cones from neonatal rat forebrain. Neurosci 1984; 13:119-136.
31. Bradford HF. Fundamentos de Nueroquímica. Barcelona: Ed. Labor S.A. 1988.
32. Baldellou A, Salazar MI, García Vera C, Gascón A, Gracia J, Tamparillas M. Critical evaluation of a phenylketonuria newborn screening through analysis of retested cases. Dev Brain Dysfunct 1993; 6:188-192.