Comparison of the Ki-67 score and S-phase fraction as prognostic variables in soft tissue saucoma

British Journal of Cancer

Volumn 79, Issue 5-6, 1999, Pages 945-951

  Huuhtanen, R L ^d   Blomqvist, C P ^d   Wiklund, T A ^d   Bohling T O ^a   Virolainen, M J ^a   Tukiainen, E J ^b   Tribukait, B ^c   Andersson, L C ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b Department of Plastic Surgery   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d NONE

Author keywords

Flow cytometry; Immunohistochemistry; Ki 67; Prognosis; S phase; Soft tissue sarcoma

Indexed keywords

KI 67 ANTIGEN;

ARTICLE; CELL CYCLE S PHASE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIMB TUMOR; MAJOR CLINICAL STUDY; PLOIDY; PRIORITY JOURNAL; PROGNOSIS; RISK ASSESSMENT; SOFT TISSUE SARCOMA; SURVIVAL RATE; TRUNK; TUMOR VOLUME;

EID: 0344767546     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690151     Document Type: Article

References (31)

1. Altman D (1994) Relation between two continuous variables. In Practical Statistics for Medical Research, pp. 293-294. Chapman and Hall: London
2. Camplejohn RS, Ash CM, Gillett CE et al (1995) The prognostic significance of DNA flow cytometry in breast cancer: results from 881 patients treated in a single centre. Br J Cancer 71: 140-145
3. Choong PF, Akerman M, Willen H et al (1994) Prognostic value of Ki-67 expression in 182 soft tissue sarcomas. Proliferation - a marker of metastasis? APMIS 102: 915-924
4. Collin F, Chassevent A, Bonichon F et al (1997) Flow cytometric DNA content analysis of 185 soft tissue neoplasms indicates that S-phase fraction is prognostic factor for sarcomas. French Federation of Cancer Centers (FNCLCC) Sarcoma Group. Cancer 79: 2371-2379
5. Dettmar P, Harbeck N, Thomssen C et al (1997) Prognostic impact of proliferation-associated factors MIB1 (Ki-67) and S-phase in node-negative breast cancer. Br J Cancer 75: 1525-1533
6. Drobnjak M, Latres E, Pollack D et al (1994) Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas. J Natl Cancer Inst 86: 549-554
7. Enzinger J and Weiss S (1995) Soft Tissue Tumor. Mosby Year-Book: St. Louis
8. Fletcher J (1995) Cytogenetic analysis of soft tissue tumors. In Soft Tissue Tumors. Enzinger F and Weiss S (eds.), pp. 105-118. Mosby-Year Book: St. Louis
9. Gasparini G, Boracchi P, Verderio P and Bevilacqua P (1994) Cell kinetics in human breast cancer: comparison between the prognostic value of the cytofluorimetric S-phase fraction and that of the antibodies to Ki-67 and PCNA antigens detected by immunocytochemistry. Int J Cancer 57: 822-829
10. Gerdes J, Li L, Schlueter C et al (1991) Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67. Am J Pathol 138: 867-873
11. Gustafson P, Ferno M, Akerman M et al (1997) Flow cytometric S-phase fraction in soft-tissue sarcoma: prognostic importance analysed in 160 patients. Br J Cancer 75: 94-100
12. Hedley DW (1989) Flow cytometry using paraffin-embedded tissue: five years on. Cytometry 10: 229-241
13. Heiden T, Wang N and Tribukait B (1991) An improved Hedley method for preparation of paraffin-embedded tissues for flow cytometric analysis of ploidy and S-phase. Cytometry 12: 614-621
14. Huuhtanen RL, Blomqvist CP, Wiklund TA et al (1996) S-phase fraction of 155 soft tissue sarcomas: correlation with clinical outcome. Cancer 77: 1815-1822
15. Joensuu H, Toikkanen S and Klemi PJ (1990) DNA index and S-phase fraction and their combination as prognostic factors in operable ductal breast carcinoma. Cancer 66: 331-340
16. Keshgegian AA and Cnaan A (1995) Proliferation markers in breast carcinoma. Mitotic figure count. S-phase fraction, proliferating cell nuclear antigen, Ki-67 and MIB-1. Am J Clin Pathol 104: 42-49
17. Levine EA, Holzmayer T, Bacus S et al (1997) Evaluation of newer prognostic markers for adult soft tissue sarcomas. J Clin Oncol 15: 3249-3257
18. Molino A, Micciolo R, Turazza M et al (1997). Ki-67 immunostaining in 322 primary breast cancers: associations with clinical and pathological variables and prognosis. Int J Cancer 74: 433-437
19. Pierga JY, Leroyer A, Viehl P et al (1996) Long term prognostic value of growth fraction determination by Ki-67 immunostaining in primary operable breast cancer. Breast Cancer Res Treat 37: 57-64
20. Railo M, Nordling S, von Boguslawsky K et al (1993) Prognostic value of Ki-67 immunolabelling in primary operable breast cancer. Br J Cancer 68: 579-583
21. Railo M, Lundin J, Haglund C et al (1997) Ki-67, p53, ER-receptors, ploidy and S-phase as prognostic factors in T1 node negative breast cancer. Acta Oncol 36: 369-374
22. Rudolph P, Kellner U, Chassevent A et al (1997) Prognostic relevance of a novel proliferation marker, ki-s11, for soft-tissue sarcoma - a multivariate study. Am J Pathol 150: 1997-2007
23. Sheer D, (1997) Chromosomes in solid tumors. In: Introduction to the Cellular and Molecular Biology of Cancer. Franks LM and Teich NM (eds.), pp. 217-220. Oxford University Press: London
24. Sigurdsson H, Baldetorp B, Borg A et al (1990) Flow cytometry in primary breast cancer: improving the prognostic value of the fraction of cells in the S-phase by optimal categorisation of cut-off levels (see comments). Br J Cancer 62: 786-790
25. Ueda T, Aozasa K, Tsujimoto M et al (1989). Prognostic significance of Ki-67 reactivity in soft tissue sarcomas. Cancer 63: 1607-1116
26. Veronese SM, Gambacorta M, Gottardi O et al (1993) Proliferation index as a prognostic marker in breast cancer. Cancer 71: 3926-3931
27. Weikel W, Beck T, Mitze M and Knapstein PG (1991) Immunohistochemical evaluation of growth fractions in human breast cancers using monoclonal antibody Ki-67. Breast Cancer Res Treat 18: 149-154
28. Weikel W, Brumm C, Wilkens C, Beck T and Knapstein PG (1995). Growth fractions (Ki-67) in primary breast cancers, with particular reference to node-negative tumors. Cancer Detect Prev 19: 446-450
29. Wiklund T, Huuhtanen R, Blomqvist C et al (1996) The importance of a multidisciplinary group in the treatment of soft tissue sarcomas. Eur J Cancer 32(A): 269-273
30. Yang P, Hirose T, Hasegawa T et al (1995) Prognostic implication of the p53 protein and Ki-67 antigen immunohistochemistry in malignant fibrous histiocytoma. Cancer 76: 618-625
31. Zehr RJ, Bauer TW, Marks KE and Weltevreden A (1990) Ki-67 and grading of malignant fibrous histiocytomas. Cancer 66: 1984-1990