Effect of Testosterone and Season on Proenkephalin Messenger RNA Expression in the Preoptic Area of the Hypothalamus in the Ram

Biology of Reproduction

Volumn 69, Issue 6, 2003, Pages 2015-2021

  Scott, Christopher J ^a,c   Mariani, Michael ^a   Clarke, Iain J ^b   Tilbrook, Alan J ^a  

^a MONASH UNIVERSITY   (Australia)

^b HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c CHARLES STURT UNIVERSITY   (Australia)

Author keywords

Hypothalamus; Male sexual function; Neuroendocrinology; Seasonal reproduction; Testosterone

Indexed keywords

LUTEINIZING HORMONE; MESSENGER RNA; PROENKEPHALIN; TESTOSTERONE PROPIONATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; BREEDING; CASTRATION; CONTROLLED STUDY; DIAGONAL BAND OF BROCA; GENE EXPRESSION; HYPOTHALAMUS; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; HYPOTHESIS; IN SITU HYBRIDIZATION; LUTEINIZING HORMONE BLOOD LEVEL; NONHUMAN; PREOPTIC AREA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SEASONAL VARIATION; SEXUAL FUNCTION; SHEEP; STRIA TERMINALIS; TESTOSTERONE BLOOD LEVEL;

ANIMALS; ENKEPHALINS; GENE EXPRESSION REGULATION; HYPOTHALAMUS; LUTEINIZING HORMONE; MALE; PREOPTIC AREA; PROTEIN PRECURSORS; RNA, MESSENGER; SEASONS; SHEEP; TESTOSTERONE; TESTOSTERONE PROPIONATE;

ANIMALIA; OVIS ARIES;

EID: 0344738988     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.103.016956     Document Type: Article

References (45)

1. Mooradian AD, Morley JE, Korenman SG. Biological actions of androgens. Endocr Rev 1987; 8:1-28.
2. Rubinow DR, Schmidt PJ. Androgens, brain, and behavior. Am J Psychiatry 1996; 153:974-984.
3. Tilbrook AJ, De Kretser DM, Cummins JT, Clarke IJ. The negative feedback effects of testicular steroids are predominantly at the hypothalamus in the ram. Endocrinology 1991; 129:3080-3092.
4. Jackson GL, Kuehl D, Rhim TJ. Testosterone inhibits gonadotropin-releasing hormone pulse frequency in the male sheep. Biol Reprod 1991; 45:188-194.
5. Bhanot R, Wilkinson M. The inhibitory effect of opiates on gonadotrophin secretion is dependent upon gonadal steroids. J Endocrinol 1984; 102:133-141.
6. Caraty A, Locatelli A, Schanbacher B. [(Augmentation, by naloxone, of the frequency and amplitude of LH-RH pulses in hypothalamohypophyseal portal blood in the castrated ram] Augmentation par la naloxone de la frequence et de l'amplitude des pulses de LH-RH dans le sang porte hypothalamo-hypophysaire chez le belier castre. C R Acad Sci III 1987; 305:369-374.
7. Lincoln GA, Ebling FJ, Martin GB. Endogenous opioid control of pulsatile LH secretion in rams: modulation by photoperiod and gonadal steroids. J Endocrinol 1987; 115:425-438.
8. Marson L, Lauterio TJ, Della-Fera MA, Baile CA. Immunohistochemical distribution of cholecystokinin, dynorphin A and met-enkephalin neurons in sheep hypothalamus. Neurosci Lett 1987; 81:35-40.
9. Blum M, Roberts JL, Wardlaw SL. Androgen regulation of proopiomelanocortin gene expression and peptide content in the basal hypothalamus. Endocrinology 1989; 124:2283-2288.
10. Wardlaw SL, Blum M. Biphasic effect of orchiectomy on pro-opiomelanocortin gene expression in the hypothalamus. Neuroendocrinology 1990; 52:521-526.
11. Hileman SM, Lubbers LS, Petersen SL, Kuehl DE, Scott CJ, Jackson GL. Influence of testosterone on LHRH release, LHRH mRNA and proopiomelanocortin mRNA in male sheep. J Neuroendocrinol 1996; 8:113-121.
12. Hileman SM, Kuehl DE, Jackson GL. Photoperiod affects the ability of testosterone to alter proopiomelanocortin mRNA, but not luteinizing hormone-releasing hormone mRNA, levels in male sheep. J Neuroendocrinol 1998; 10:587-592.
13. Bittman EL, Tubbiola ML, Foltz G, Hegarty CM. Effects of photo-period and androgen on proopiomelanocortin gene expression in the arcuate nucleus of golden hamsters. Endocrinology 1999; 140:197-206.
14. Armstrong JD, Spears JW. Changes in growth hormone and luteinizing hormone following acute or chronic administration of an opioid agonist, FK33-824, in wethers. J Anim Sci 1991; 69:774-781.
15. Rodriguez-Manzo G, Asai M, Fernandez-Guasti A. Evidence for changes in brain enkephalin contents associated to male rat sexual activity. Behav Brain Res 2002; 131:47-55.
16. Nikolarakis KE, Almeida OF, Herz A. Multiple factors influencing the in vitro release of [Met5]-enkephalin from rat hypothalamic slices. J Neurochem 1989; 52:428-432.
17. Johansson P, Lindqvist AS, Nyberg F, Fahlke C. Anabolic androgenic steroids affects alcohol intake, defensive behaviors and brain opioid peptides in the rat. Pharmacol Biochem Behav 2000; 67:271-279.
18. Walsh JP, Rao A, Thompson RC, Clarke IJ. Proenkephalin and opioid mu-receptor mRNA expression in ovine hypothalamus across the estrous cycle. Neuroendocrinology 2001; 73:26-36.
19. O'Hara BF, Watson FL, Srere HK, Kumar H, Wiler SW, Welch SK, Bitting L, Heller HC, Kilduff TS. Gene expression in the brain across the hibernation cycle. J Neurosci 1999; 19:3781-3790.
20. Bremner WJ, Cumming IA, Winfield CG, De Kretser DM, Galloway DB. A study of the reproductive performance of mature Romney and Merino rams throughout the year. In: Lindsay DR, Pearce DT (eds.), Reproduction in Sheep. Canberra: Australian Academy of Science and Australian Wool Corporation; 1984;16-17.
21. Tilbrook AJ, De Kretser DM, Clarke IJ. Seasonal changes in the negative feedback regulation of the secretion of the gonadotrophins by testosterone and inhibin in rams. J Endocrinol 1999; 160:155-167.
22. Lee VWK, Cumming IA, De Kretser DM, Findlay JK, Hudson B, Keogh EJ. Regulation of gonadotrophin secretion in rams from birth to sexual maturity I. Plasma LH, FSH and testosterone levels. J Reprod Fertil 1976; 46:1-6.
23. Simmons DM, Arriza JL, Swanson LW. A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radio-labeled single-stranded RNA probes. J Histotechnol 1989; 12:169-181.
24. Scott CJ, Tilbrook AJ, Simmons DM, Rawson JA, Chu S, Fuller PJ, Ing NH, Clarke IJ. The distribution of cells containing estrogen receptor-alpha (ERalpha) and ERbeta messenger ribonucleic acid in the preoptic area and hypothalamus of the sheep: comparison of males and females. Endocrinology 2000; 141:2951-2962.
25. Mansour A, Fox CA, Burke S, Meng F, Thompson RC, Akil H, Watson SJ. Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS-an in situ hybridization study. J Comp Neurol 1994; 350:412-438.
26. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press; 1989.
27. Karsch FJ, Cummins JT, Thomas GB, Clarke IJ. Steroid feedback inhibition of pulsatile secretion of gonadotropin-releasing hormone in the ewe. Biol Reprod 1987; 36:1207-1218.
28. Geschwind II, Dewey R. Dynamics of luteinizing hormone (LH) secretion in the cycling ewe: a radioimmunoassay study. Proc Soc Exp Biol Med 1968; 129:451-455.
29. Matthews SG, Heavens RP, Sirinathsinghji DJ. Distribution and cellular localization of preproenkephalin mRNA in the ovine brain and pituitary. Mol Brain Res 1992; 12:349-355.
30. Herbison AE, Skinner DC, Robinson JE, King IS. Androgen receptor-immunoreactive cells in ram hypothalamus: distribution and co-localization patterns with gonadotropin-releasing hormone, somatostatin and tyrosine hydroxylase. Neuroendocrinology 1996; 63:120-131.
31. Henry BA, Tilbrook AJ, Dunshea FR, Rao A, Blache D, Martin GB, Clarke IJ. Long-term alterations in adiposity affect the expression of melanin-concentrating hormone and enkephalin but not proopiomelanocortin in the hypothalamus of ovariectomized ewes. Endocrinology 2000; 141:1506-1514.
32. Baile CA, McLaughlin CL, Buonomo FC, Lauterio TJ, Marson L, Della-Fera MA. Opioid peptides and the control of feeding in sheep. Fed Proc 1987; 46:173-177.
33. Lincoln GA, Richardson M. Photo-neuroendocrine control of seasonal cycles in body weight, pelage growth and reproduction-lessons from the HPD sheep model. Comp Biochem Physiol 1998; 119:283-294.
34. Clarke IJ, Scott CJ, Rao A, Pompolo S, Barker-Gibb ML. Seasonal changes in the expression of neuropeptide Y and pro-opiomelanocortin mRNA in the arcuate nucleus of the ovariectomized ewe: relationship to the seasonal appetite and breeding cycles. J Neuroendocrinol 2000; 12:1105-1111.
35. Hammer RP, Bogic L, Handa RJ. Estrogenic regulation of proenkephalin messenger RNA expression in the ventromedial hypothalamus of the adult male rat. Mol Brain Res 1993; 19:129-134.
36. Broad KD, Kendrick KM, Sirinathsinghji DJS, Keverne EB. Changes in pro-opiomelanocortin and pre-proenkephalin mRNA levels in the ovine brain during pregnancy, parturition and lactation and in response to oestrogen and progesterone. J Neuroendocrinol 1993; 5:711-719.
37. Blache D, Fabre-Nys CJ, Venier G. Ventromedial hypothalamus as a target for oestradiol action on proceptivity, receptivity and luteinizing hormone surge of the ewe. Brain Res 1991; 546:241-249.
38. Scott CJ, Kuehl DE, Ferreira SA, Jackson GL. Hypothalamic sites of action for testosterone, dihydrotestosterone, and estrogen in the regulation of luteinizing hormone secretion in male sheep. Endocrinology 1997; 138:3686-3694.
39. Romano GJ, Mobbs CV, Lauber A, Howells RD, Pfaff DW. Differential regulation of proenkephalin gene expression by estrogen in the ventromedial hypothalamus of male and female rats: implications for the molecular basis of a sexually differentiated behavior. Brain Res 1990; 536:63-68.
40. Priest CA, Borsook D, Pfaff DW. Estrogen and stress interact to regulate the hypothalamic expression of a human proenkephalin promoter-beta-galactosidase fusion gene in a site-specific and sex-specific manner. J Neuroendocrinol 1997; 9:317-326.
41. Xu ZZ, McDonald MF, McCutcheon SN, Blair HT. Effects of season and testosterone treatment on gonadotrophin-releasing hormone in castrated Romney and Poll Dorset rams. J Reprod Fertil 1992; 95:183-190.
42. Raitiere MN, Garyfallou VT, Urbanski HF. Lesions in the anterior bed nucleus of the stria terminalis in Syrian hamsters block short-photo-period-induced testicular regression. Biol Reprod 1997; 57:796-806.
43. Lehman MN, Karsch FJ. Do gonadotropin-releasing hormone, tyrosine hydroxylase- and β-endorphin-immunoreactive neurons contain estrogen receptors? A double-label immunocytochemical study in the Suffolk ewe. Endocrinology 1993; 133:887-895.
44. Akil H, Watson SJ, Young E, Lewis ME, Khachaturian H, Walker JM. Endogenous opioids: biology and function. Annu Rev Neurosci 1984; 7:223-255.
45. Sannella MI, Petersen SL. Dual label in situ hybridization studies provide evidence that luteinizing hormone-releasing hormone neurons do not synthesize messenger ribonucleic acid for mu, kappa, or delta opiate receptors. Endocrinology 1997; 138:1667-1672.