DNA Sequence Motifs Conserved in Endocrine Promoters Are Essential for Pax4 Expression

Developmental Dynamics

Volumn 228, Issue 4, 2003, Pages 617-622

  Brink, Christopher ^a,b   Gruss, Peter ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

A2 element; E1 element; Islet of Langerhans; Pancreas; Pax4

Indexed keywords

GENOMIC DNA; INSULIN; NEUROGENIC DIFFERENTIATION FACTOR; SOMATOSTATIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX4; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DNA SEQUENCE; EMBRYO; GENE EXPRESSION; MOUSE; NEWBORN; NONHUMAN; PANCREAS; PANCREAS ISLET; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENIC MOUSE;

AMINO ACID MOTIFS; ANIMALS; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DNA; GENE DELETION; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; HOMEODOMAIN PROTEINS; HUMANS; LAC OPERON; MICE; MICE, TRANSGENIC; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; PROMOTER REGIONS (GENETICS); TIME FACTORS; TISSUE DISTRIBUTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

MURINAE;

EID: 0344737861     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.10405     Document Type: Article

References (19)

1. Brink C. 2003. Promoter elements in endocrine pancreas development and hormone regulation (review). Cell Mol Life Sci 60:1033-1048.
2. Brink C, Chowdhury K, Gruss P. 2001. Pax4 regulatory elements mediate beta cell specific expression in the pancreas. Mech Dev 100:37-43.
3. Carty MD, Lillquist JS, Peshavaria M, Stein R, Soeller WC. 1997. Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta cells. J Biol Chem 272:11986-11993.
4. Edlund H. 1998. Transcribing pancreas. Diabetes 47:1817-1823.
5. German M, Ashcroft S, Docherty K, Edlund H, Edlund T, Goodison S, Imura H, Kennedy G, Madsen O, Melloul D, Moss L, Olson K, Permutt MA, Pilippe J, Robertson RP, Rutter WJ, Serup P, Stein R, Steiner D, Tsai MJ, Walker MD. 1995. The insulin gene promoter. A simplified nomenclature. Diabetes 44:1002-1004.
6. Gradwohl G, Dierich A, LeMeur M, Guillemot F. 2000. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A 97:1607-1611.
7. Hogan B, Beddington R, Costantini F, Lacy E. 1994. Manipulating the mouse embryo. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
8. Jonsson J, Carlsson L, Edlund T, Edlund H. 1994. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-609.
9. Kammandel B, Chowdhury K, Stoykova A, Aparicio S, Brenner S, Gruss P. 1999. Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity. Dev Biol 205:79-97.
10. Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ. 1997. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice. Genes Dev 11:2323-2334.
11. Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BLM, Wright CVE. 1996. Pdx-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122:983-996.
12. Qiu Y, Guo M, Huang S, Stein R. 2002. Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47. Mol Cell Biol 22:412-420.
13. Slack JMW. 1995. Developmental biology of the pancreas. Development 121:1569-1580.
14. Smith SB, Watada H, Scheel DW, Mrejen C, German MS. 2000. Autoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoter. J Biol Chem 24:36910-36919.
15. Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P. 1997. The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature 386:399-402.
16. St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P. 1997. Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature 387:406-409.
17. Watada H, Mirmira RG, Leung J, German MS. 2000. Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1. J Biol Chem 275:34224-34230.
18. Xu W, Murphy LJ. 2000. Cloning of the mouse Pax4 gene promoter and identification of a pancreatic beta cell specific enhancer. Mol Cell Endocrinol 22:79-89.
19. Yamaoka T, Itakura M. 1999. Development of pancreatic islets. Int J Mol Med 3:247-261.