Novel, testis-specific mRNA transcripts encoding N-terminally truncated choline acetyltransferase

Molecular Reproduction and Development

Volumn 53, Issue 3, 1999, Pages 274-281

  Lönnerberg, Peter ^a   Ibáñez, Carlos F ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cholinergic; Gene expression; Spermatozoa

Indexed keywords

ACETYL COENZYME A; AMINO ACID; CHOLINE; CHOLINE ACETYLTRANSFERASE; COMPLEMENTARY DNA; MESSENGER RNA; PROTEIN;

ANIMAL CELL; ARTICLE; DNA LIBRARY; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION; GENE LOCUS; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT; TESTIS;

5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; CHOLINE O-ACETYLTRANSFERASE; CLONING, MOLECULAR; COS CELLS; DNA, COMPLEMENTARY; MALE; MOLECULAR SEQUENCE DATA; NEURONS; PROTEIN BIOSYNTHESIS; RATS; RATS, SPRAGUE-DAWLEY; RIBONUCLEASES; RNA, MESSENGER; TESTIS;

ANIMALIA; MAMMALIA;

EID: 0344731337     PISSN: 1040452X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2795(199907)53:3<274::AID-MRD3>3.0.CO;2-8     Document Type: Article

References (37)

1. Bejanin S, Cervini R, Mallet J, Berrard S. 1994. A unique gene organization for two cholinergic markers, choline acetyltransferase and a putative transporter of acetylcholine. J Biol Chem 269:21944-21947.
2. Bishop MR, Rama Sastry BV, Schmidt DE, Harbison RD. 1976. Occurrence of choline acetyltransferase and acetylcholine and other quarternary ammonium compounds in mammalian spermatozoa. Biochem Pharmacol 25:1617-1622.
3. Brenman JE, Xia H, Chao DS, Black SM, Bredt DS. 1997. Regulation of neuronal nitric oxide synthase through alternative transcripts. Dev Neurosci 19:224-231.
4. Brice A, Berrard S, Raynaud B, Anseau S, Coppola T, Weber MJ, Mallet J. 1989. Complete sequence of a cDNA encoding an active rat choline acetyltransferase: a tool to investigate the plasticity of cholinergic phenotype expression. J Neurosci 23:266-273.
5. Carbini LA, Hersch LB. 1993. Functional analysis of conserved histidines in choline acetyltransferase by site-directed mutagenesis. J. Neurochem 61:247-253.
6. Douglass J, Cox B, Quinn B, Civelli O, Herbert E. 1987. Expression of the prodynorphin gene in male and female mammalian reproductive tissues. Endocrinology.
7. Dwivedi C. 1983. Cadmium-induced sterility: possible involvement of the cholinergic system. Arch Environ Contam Toxicol 12:151-156.
8. Erickson JD, Varoqui H, Schäfer MK-H, Modi W, Diebler M-F, Weihe E, Rand J, Eiden LE, Bonner TI, Usdin TB. 1994. Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locus. J Biol Chem 269:21929-21932.
9. Finocchiaro G, Taroni F, Rocchi M, Liras Martin A, Colombo I, Torri Tarelli G, DiDonato S. 1991. cDNA cloning, sequence analysis, and chromosomal localization of the gene for human carnitine palmitoyl-transferase. Proc Natl Acad Sci USA 88:661-665.
10. Fonnum F. 1975. A rapid radiochemical method for the determination of choline acetyltransferase. J Neurochem 24:407-409.
11. Goodman DR, Adatsi FK, Harbison RD. 1984. Evidence for the extreme overestimation of choline acetyltransferase in human sperm, human seminal plasma, and rat heart: A case of mistaking carnitine acetyltransferase for choline acetyltransferase. Chem Biol Interact 49:39-53.
12. Goodman DR, Harbison RD. 1981. Characterization of enzymatic acetylcholine synthesis by mouse brain, rat sperm, and purified carnitine acetyltransferase. Biochem Pharmacol 30:1521-1528.
13. Hahn M, Hahn S, Stone D, Joh T. 1992. Cloning of the rat gene encoding choline acetyltransferase, a cholinergic neuron-specific marker. Proc Natl Acad Sci USA 89:4387-4391.
14. Harbison RD, Dwivedi C, Evans MA. 1976. A proposed mechanism for trimethylphosphate-induced sterility. Toxicol Appl Pharmacol 25: 481-490.
15. Howard TE, Shai S-Y, Langford KG, Martin BM, Bernstein KE. 1990. Transcription of testicular angiotensin-converting enzyme (ACE) is initiated within the 12th intron of the somatic ACE gene. Mol Cell Biol 10:4294-4302.
16. Ibáñez CF, Pelto-Huikko M, Söder O, Ritzén EM, Hersch LB, Hökfelt T, Persson H. 1991. Expression of choline acetyltransferase mRNA in spermatogenic cells results in an accumulation of the enzyme in the postacrosomal region in mature spermatozoa. Proc Natl Acad Sci USA 88:3676-3680.
17. Ibáñez CF, Persson H. 1991. Localization of sequences determining cell type specificity and NGF responsiveness in the promoter region of the rat choline acetyltransferase gene. Eur J Neurosci 3:1309-1315.
18. Ishii K, Oda Y, Ichikawa T, Deguchi T. 1990. Complementary DNAs for choline acetyltransferase from spinal cords of rat and mouse: nucleotide sequences, expression in mammalian cells, and in situ hybridization. Brain Res Mol Brain Res 7:151-159.
19. Kengaku M, Misawa H, Deguchi T. 1993. Multiple mRNA species of choline acetyltransferase from rat spinal cord. Brain Res Mol Brain Res 18:71-76.
20. Kilpatrick DL, Rosenthal JL. 1986. The proenkephalin gene is widely expressed within the male and female reproductive systems of the rat and hamster. Endocrinology 119:370-374.
21. Klapproth H, Reinheimer T, Metzen J, Munch M, Bittinger F, Kirkpatrick CJ, Höhle K-D, Schemann M, Racké K, Wessler I. 1997. Non-neuronal acetylcholine, a signaling molecule synthesized by surface cells of rat and man. Naunyn Schmiedbergs Arch Pharmacol 355:515-523.
22. Kozak M. 1996. Interpreting cDNA sequences: some insights from studies on translation. Mamm Genome 7:563-574.
23. Krege JH, John SW, Langenbach LL, Hodgin JB, Hagaman JR, Bachman ES, Jennette JC, O'Brien DA, Smithies O. 1995. Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature 375:145-148.
24. Meng J-P, Zhang F-P, Huhtaniemi I, Pakarinen P. 1997. Characterization and developmental expression of a testis-specific adenosine deaminase mRNA in the mouse. J Androl 18:88-95.
25. Persson H, Rehfeld JF, Ericsson A, Schalling M, Pelto-Huikko M, Hökfelt T. 1989. Transient expression of the cholecystokinin gene in male germ cells and accumulation of the peptide in the acrosomal granule: possible role of cholecystokinin in fertilization. Proc Natl Acad Sci USA 86:6166-6170.
26. Persson H, Pelto-Huikko M, Metsis M, Söder O, Brené S, Skog S, Hökfelt T, Ritzén EM. 1990. Expression of the neurotransmitter-synthesizing enzyme glutamic acid decarboxylase in male germ cells. Mol Cell Biol 10:4701-4711.
27. Rama Sastry BV, Janson VE, Chaturvedi AK. 1981. Inhibition of human sperm motility by inhibitors of choline acetyltransferase. J Pharmacol Exp Ther 216:378-384.
28. Rama Sastry BV, Sadavongvidad C. 1979. Cholinergic systems in non-nervous tissues. Pharmacol Rev 30:65-132.
29. Ramaraj P, Kessler SP, Colmenares C, Sen GC. 1998. Selective restoration of male fertility in mice lacking angiotensin-converting enzymes by sperm-specific expression of the testicular isozyme. J Clin Invest 102:371-378.
30. Schalling M, Persson H, Pelto HM, Odum L, Ekman P, Gottlieb C, Hokfelt T, Rehfeld JF. 1990. Expression and localization of gastrin messenger RNA and peptide in spermatogenic cells. J Clin Invest 86:660-669.
31. Stewart TA, Forrester IT. 1978. Acetylcholinesterase and choline acetyltransferase in ram spermatozoa. Biol Reprod 19:271-279.
32. Toussaint C, Bousquet-Lemercier B, Garlatti M, Hanoune J, Barouki R. 1994. Testis-specific transcription start site in the aspartate aminotransferase housekeeping gene promoter. J Biol Chem 269: 13318-13324.
33. Tsong SD, Phillips D, Halmi N, Liotta AS, Margioris A, Bardin CW, Krieger DT. 1982. ACTH and beta-endorphin-related peptides are present in multiple sites in the reproductive tract of the male rat. Endocrinology 110:2204-2206.
34. Waeber G, Meyer TE, LeSieur M, Hermann HL, Gérard N, Habener JF. 1991. Developmental stage-specific expression of cyclic adenosine 3'-5'-monophosphate response element-binding protein CREB during spermatogenesis involves alternative exon splicing. Mol Endocrinol 5:1418-1430.
35. Walker WW, Sanborn BM, Habener JF. 1994. An isoform of transcription factor CREM expressed during spermatogenesis lacks the phosphorylation domain and represses cAMP-induced transcription. Proc Natl Acad Sci USA 91:12423-12427.
36. Wang Y, Goligorsky MS, Lin M, Wilcox JN, Marsden PA. 1997. A novel, testis-specific mRNA transcript encoding an NH2-terminal truncated nitric-oxide synthase. J Biol Chem 272:11392-11401.
37. Zhang F, Rannikko A, Huhtaniemi I. 1995. Isolation and characterization of testis-specific cDNAs for luteinizing hormone beta-subunit in the rat. Biochem Biophys Res Commun 210:858-865.