Bactericidal activity of antibodies elicited against the Neisseria meningitidis 37-kDa ferric binding protein (FbpA) with different adjuvants

FEMS Immunology and Medical Microbiology

Volumn 20, Issue 1, 1998, Pages 79-86

  Gomez J A ^a   Criado, M T ^a   Ferreiros C M ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Adjuvant; Bactericidal activity; FbpA; Neisseria meningitidis

Indexed keywords

ADJUVANT; ALUMINUM HYDROXIDE; BACTERIAL VACCINE; FREUND ADJUVANT; IRON BINDING PROTEIN; QUIL A;

AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; ANTIGENICITY; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNIZATION; IMMUNOBLOTTING; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NEISSERIA MENINGITIDIS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PURIFICATION;

ADJUVANTS, IMMUNOLOGIC; ALUMINUM HYDROXIDE; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL PROTEINS; CROSS REACTIONS; FERRIC COMPOUNDS; FREUND'S ADJUVANT; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; MICE; MICE, INBRED BALB C; NEISSERIA MENINGITIDIS; VACCINATION;

EID: 0344701093     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(97)00109-0     Document Type: Article

References (29)

1. Ala'Aldeen, D.A.A., Stevenson, P., Griffiths, E., Gorringe, A.R., Irons, L.I., Robinson, A., Hyde, S. and Borriello, S.P. (1994) Immune responses in humans and animals to meningococcal transferrin-binding proteins: implications for vaccine design. Infect. Immun. 62, 2984-2990.
2. Ferreirós, C.M., Ferrón, L. and Criado, M.T. (1994) In vivo human immune response to transferrin-binding protein 2 and other iron-regulated proteins of Neisseria meningitidis. FEMS Immunol. Med. Microbiol. 8, 63-68.
3. Gorringe, A.R., Borrow, R., Fox, A.J. and Robinson, A. (1995) Human antibody response to meningococcal transferrin binding proteins: evidence for vaccine potential. Vaccine 13, 1207-1212.
4. Lissolo, L., Maitre-Wilmotte, G., Dumas, P., Mignon, M., Danve, B. and Quentin-Millet, M.-J. (1995) Evaluation of transferrin-binding protein 2 within the transferrin-binding protein complex as a potential antigen for future meningococcal vaccines. Infect. Immun. 63, 884-890.
5. Ala'Aldeen, D.A.A. and Borriello, S.P. (1996) The meningococcal transferrin-binding proteins 1 and 2 are both surface exposed and generate bactericidal antibodies capable of killing homologous and heterologous strains. Vaccine 14, 49-53.
6. Pintor, M., Ferrón, L., Gómez, J.A., Powell, N.B.L., Ala'Aldeen, D.A.A., Borriello, S.P., Criado, M.T. and Ferreirós, C.M. (1996) Blocking of iron uptake from transferrin by antibodies against the transferrin binding proteins in Neisseria meningitidis. Microb. Pathogen. 20, 127-139.
7. Mietzner, T.A., Luginbuhl, G.H., Sandstrom, E. and Morse, S.A. (1984) Identification of an iron-regulated 37,000-dalton protein in the cell envelope of Neisseria gonorrhoea. Infect. Immun. 45, 410-416.
8. Mietzner, T.A., Barnes, R.C., Jeanlouis, Y.A., Shafer, W.H. and Morse, S.A. (1986) Distribution of an antigenically related iron-regulated protein among the Neisseria spp. Infect. Immun. 51, 60-68.
9. Gómez, J.A., Agra, C., Ferrón, L., Powell, N., Pintor, M., Criado, M.T. and Ferreirós, C.M. (1996) Antigenicity, cross-reactivity and surface exposure of the Neisseria meningitidis 37 kDa protein (Fbp). Vaccine 14, 1430-1436.
10. Ferrón, L., Pintor, M., Gómez, J.A., Criado, M.T. and Ferreirós, C. (1996) One-step metal-affinity method for the purification of the iron-binding protein Fbp of Neisseria meningitidis. J. Microbiol. Methods 25, 233-236.
11. Genco, C.A., Berish, S.A., Chen, C.-Y., Morse, S. and Trees, D.L. (1994) Genetic diversity of the iron-binding protein (Fbp) gene of the pathogenic and commensal Neisseria. FEMS Microbiol. Lett. 116, 123-130.
12. Audibert, F.M. and Lise, L.D. (1993) Adjuvants: current status, clinical perspectives and future prospects. Immunol. Today 14, 281-284.
13. Gupta, R.K. and Siber, G.R. (1995) Adjuvants for human vaccines - current status, problems and future prospects. Vaccine 13, 1263-1276.
14. Smith, P.K., Krohn, R.I., Hermason, G.T., Mallia, A.K., Gartner, F.H., Provenzano, M.D., Fujimoto, E.K., Goeke, N.M., Olson, B.J. and Clenk, D.C. (1985) Measurement of protein using Bicinchoninic acid. Anal. Biochem. 150, 76-85.
15. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature 277, 680-685.
16. Chase, M.W. (1967) Production of antiserum. Methods Immunol. Immunochem. 1, 97-209.
17. Fletcher, J.N., Zak, K., Virji, M. and Heckels, J.E. (1986) Monoclonal antibodies to gonococcal outer membrane protein I: location of a conserved epitope on protein IB. J. Gen. Microbiol. 132, 1611-1620.
18. Zollinger, W.D., Brandt, B.L., Tramont, E.C. and Dobek, A.S. (1980) Immune response to Neisseria meningitidis. In: Manual of Clinical Immunology (Rose, N.R. and Friedman, H., Eds.), pp. 446-453. American Society for Microbiology, Washington, DC.
19. Goldschneider, I., Gotschlich, E.C. and Artenstein, M.S. (1969) Human immunity to the meningococcus. I. The role of humoral antibodies. J. Exp. Med. 129, 1307-1326.
20. Goldschneider, I., Gotschlich, E.C. and Artenstein, M.S. (1969) Human immunity to the meningococcus. II. Development of natural immunity. J. Exp. Med. 129, 1327-1348.
21. Fohn, M.J., Mietzner, T.A., Hubbard, T.W., Morse, S.A. and Hook, E.W, (1987) Human immunoglobulin G antibody response to the major gonococcal iron-regulated protein. Infect. Immun. 55, 3065-3069.
22. Zollinger, W.D. and Mandrell, R.E. (1983) Importance of complement source in bactericidal activity of human antibody and murine monoclonal antibody to meningococcal group B polysaccharide. Infect. Immun. 40, 257-264.
23. Mandrell, R.E., Azmi, F.H. and Granoff, D.M. (1995) Complement-mediated bactericidal activity of human antibodies to poly α2→8 N-acetylneuraminic acid, the capsular polysaccharide of Neisseria meningitidis serogroup B. J. Infect. Dis. 172, 1279-1289.
24. Peeters, C.C.A.M., Rümke, H.C., Sundermann, L.C., van der Voort, E.M.R., Meulenbelt, J., Schuller, M., Kuipers, A.J., van der Ley, P. and Poolman, J.T. (1996) Phase I clinical trial with a hexavalent PorA containing meningococcal outer membrane vesicle vaccine. Vaccine 14, 1009-1015.
25. Christodoulides, M. and Heckels, J.E. (1994) Immunization with a multiple antigen peptide containing defined B- and T-cell epitopes: production of bactericidal antibodies against group B Neisseria meningitidis. Microbiology 140, 2951-2960.
26. Cox, J.C. and Coulter, A.R. (1997) Adjuvants - a classification of review of their modes of action. Vaccine 15, 248-256.
27. Kenney, J.S., Hughes, B.W., Masada, M.P. and Allison, A.C. (1989) Influence of adjuvants on the quantity, affinity, isotype and epitope specificity of murine antibodies. J. Immunol. Methods 121, 157-166.
28. Satsuume-Sakai, K., Motonishi, K. and Migita, S. (1977) Quantitative estimations of five classes of immunoglobulin in inbred mouse strains. Immunology 32, 861-870.
29. Hadjipetrou-Kourounakis, L. and Moller, E. (1984) Adjuvants influence the immunoglobulin subclass distribution of immune responses in vivo. Scand. J. Immunol. 19, 214-225.