Screening for hereditary haemochromatosis within families and beyond

Lancet

Volumn 362, Issue 9399, 2003, Pages 1897-1898

  McCune, C Anne ^a   Ravine, David ^b   Worwood, Mark ^a   Jackson, Helen A ^c   Evans, H Martyn ^d   Hutton, David ^e  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c ROYAL GWENT HOSPITAL   (United Kingdom)

^d DURHAM UNIVERSITY   (United Kingdom)

^e Welsh Blood Service   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BLOOD DONOR; BLOOD EXAMINATION; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; FAMILIAL DISEASE; FEMALE; FOLLOW UP; GENETIC ANALYSIS; HEMOCHROMATOSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PRIORITY JOURNAL; SCREENING;

EID: 0344687289     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(03)14963-X     Document Type: Article

References (5)

1. Jackson H.A., Carter K., Darke C., et al. HFE mutations, iron deficiency and overload in 10 500 blood donors. Br J Haematol. 114:2001;474-484.
2. Beutler E. The HFE Cys282Tyr mutation as a necessary but not sufficient cause of clinical hereditary hemochromatosis. Blood. 101:2003;3347-3350.
3. Ajioka R.S., Kushner J.P. Clinical consequences of iron overload in hemochromatosis homozygotes. Blood. 101:2003;3351-3353.
4. Cappuccio J., Phatak P.D. Cost-effectiveness of screening for hemochromatosis. Barton J.C., Edwards C.Q. Hemochromatosis: genetics, pathophysiology, diagnosis and treatment. 2000;525-534 Cambridge University Press, Cambridge.
5. McCune C.A., Al-Jader L.N., May A., Hayes S.A., Jackson H.A., Worwood M. Hereditary haemochromatosis: only 1% of adult HFE C282Y homozygotes in South Wales have a clinical diagnosis of iron overload. Hum Genet. 111:2002;538-543.