2-substituted indazoles. Synthesis and antimicrobial activity

European Journal of Medicinal Chemistry

Volumn 34, Issue 11, 1999, Pages 1009-1018

  Lóránd, Tamás ^a   Kocsis, Béla ^a   Emôdy, Levente ^a   Sohár, Pál ^b  

^a UNIVERSITY OF PÉCS   (Hungary)

^b EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

Alkylation; Antibacterial effect; In vitro toxicity; Indazole; Stereostructure by NMR

Indexed keywords

7 BENZYLIDENE 3,3A,4,5,6,7 HEXAHYDRO 5 METHYL 2 METHYLTHIURONYL 3 PHENYL 2H PYRAZOLO[4,3 C]PYRIDINE; AMPICILLIN; ANTIINFECTIVE AGENT; CEFTRIAXONE; CEFUROXIME; CHLORAMPHENICOL; GENTAMICIN; INDAZOLE DERIVATIVE; OXACILLIN; OXYTETRACYCLINE; PENICILLIN G; PYRAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANTIMICROBIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY;

EID: 0344671601     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)00120-8     Document Type: Article

References (28)

1. Tornetta B., Arcoria A. Boll. Sci. Fac. Chim. Ind. Bologna. 14:1956;50-51.
2. Manowitz M., Walter G. J. Pharm. Sci. 54:1965;650.
3. Bauer D.J., Sadler P.W. Br. J. Pharmacol. 15:1960;101-110.
4. Searle G.D., and Co. (1975) Brit. 1, 382, 773; Chem. Abstr. (1975) 83 p58829g.
5. Hamilton R.W., (1976) U.S. 3, 940, 418 Chem. Abstr. (1976) 85 p5623v.
6. Ramalingam K., Thyvelikakath G.X., Berlin K.D., Chesmut R.W., Brown R.A., Durham N.N., Ealick S.E., Van der Helm D. J. Med. Chem. 20:1977;847-850.
7. Lóránd T., Szabó D., Földesi A., Párkányi L., Kálmán A., Neszmélyi A. J. Chem. Soc. Perkin Trans. 1:1985;481-486.
8. Tóth G., Szöllôsy Á., Lóránd T., Kónya T., Szabó D., Lévai A. J. Chem. Soc. Perkin Trans. 2:1989;319-323.
9. Szöllôsy Á., Tóth G., Lóránd T., Kónya T., Aradi F., Lévai A. J. Chem. Soc. Perkin Trans. 2:1991;489-493.
10. Walter W., Krohn J. Chem. Ber. 102:1969;3786-3794.
11. Sohár P. Cyclopentane derivatives and their heteroanalogues, in: Nuclear Magnetic Resonance Spectroscopy Vol. 2. 1983;22-23 CRC Press, Boca Raton, Florida.
12. Sohár P. The effect of structural parameters on the shielding of carbon nuclei, in: Nuclear Magnetic Resonance Spectroscopy Vol. 2. 1983;154-155 CRC Press, Boca Raton, Florida.
13. Grant D.M., Cheney B.V. J. Am. Chem. Soc. 89:1967;5315.
14. Sohár P. Fused and quasiaromatic heterocyclic systems; analogues containing more nitrogens, in: Nuclear Magnetic Resonance Spectroscopy Vol. 2. CRC Press. 1983;89-90 Boca Raton, Florida.
15. Sohár P. Geminal couplings, in: Nuclear Magnetic Resonance Spectroscopy Vol. 1. CRC Press. Vol 1:1983;55-60 Boca Raton, Florida.
16. Karpus M.J. J. Chem. Phys. 30:1959;11.
17. Karpus M.J. J. Chem. Phys. 33:1960;1842.
18. Pegg D.T., Doddrell D.M., Bendall M.R. J. Chem. Phys. 77:1982;2745.
19. Bendall M.R., Doddrell D.M., Pegg D.T., Hull W.E., High Resolution Multipulse NMR Spectra Editing and DEPT. Bruker, Karlsruhe (1982).
20. 13C-NMR signals, in: Nuclear Magnetic Resonance Spectroscopy Vol. 1. 1983;196-197 CRC Press, Boca Raton, Florida.
21. Sanders J.K.M., Mersch J.D. Prog. Nucl. Magn. Reson. 15:1982;353.
22. Ernst R.R., Bodenhausen G., Wokaun A. Principles of Nuclear Magnetic Resonance in One and Two Dimensions. 1987;471-479 Clarendon Press, Oxford.
23. Balaban A.T., Zugravescu I., Avramovici S., Silhan W. Monatsh. Chem. 101:1970;704-708.
24. Al-Nakib T.M., Bezjak V., Meegan M.J., Chandy R. Eur. J. Med. Chem. 25:1990;455-462.
25. Lévai A., Schág J.B. Pharmazie. 34:1979;749.
26. Krapcho J., Turk C.F. J. Med. Chem. 22:1979;207-210.
27. Sahm D.F., Washington J.A. Antibacterial susceptibility tests: dilution methods. Ballows A, Hausler Jr W.J, Herrmann K.L, Isenberg H.D, Shadomy H.J. Manual of Clinical Microbiology 5th. 1991;1105-1116 ASM, Washington DC.
28. Schlager S.I., Adams A.C. Use of dyes and radioisotopic markers in cytotoxicity tests. Langone J.J, Vunakis H.V. Methods in Enzymology, Vol. 93, Immunochemical Techniques Part F, Conventional Antibodies, Fc Receptors and Cytotoxicity. 1983;233-245 Academic Press Inc., San Diego, USA.