cDNA Cloning of Rabbit Thrombomodulin and Characterization of Gene Expression in Cardiovascular Tissue

DNA Sequence - Journal of DNA Sequencing and Mapping

Volumn 14, Issue 6, 2003, Pages 399-405

  Deming, Clayton B ^a   Kim, Antony Y ^a   Bian, C E ^a   Regard, Jean B ^a   Rade, Jeffrey J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cDNA; DNA Sequence; Rabbit; Thrombomodulin

Indexed keywords

COMPLEMENTARY DNA; THROMBOMODULIN;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RABBIT; THROMBOSIS; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELLS, CULTURED; CLONING, MOLECULAR; DNA, COMPLEMENTARY; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; JUGULAR VEINS; MOLECULAR SEQUENCE DATA; MYOCARDIUM; RABBITS; RATS; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; THROMBOMODULIN; TIME FACTORS;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0344667697     PISSN: 10425179     EISSN: None     Source Type: Journal    
DOI: 10.1080/10425170310001608416     Document Type: Article

References (14)

1. Bourin, M.-C., Lundgren-Akerlund, E. and Lindahl, U. (1990) "Isolation and characterization of the glycosaminoglycan component of rabbit thrombomodulin proteoglycan", J. Biol. Chem. 265, 15424-15431.
2. Dittman, W.A. and Majerus, P.W. (1990) "Structure and function of thrombomodulin; A natural anticoagulant", Blood 75, 329-336.
3. Faust, S.N., Levin, M., Harrison, O.B., Goldin, R.D., Lockhart, M.S., Kondaveeti, S., Laszik, Z., Esmon, C.T. and Heyderman, R.S. (2001) "Dysfunction of endothelial protein C activation in severe meningococcal sepsis", N. Engl. J. Med. 345, 408-416.
4. Gerlitz, B., Hassell, T., Vlahos, C.J., Parkinson, J.F., Bang, N.U. and Grinnell, B.W. (1993) "Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine474", Biochem. J. 295, 131-140.
5. Jaffe, E.A., Nachman, R.L., Becker, C.G. and Minick, C.R. (1973) "Culture of human endothelial cells derived from umbilical veins", J. Clin. Investig. 52, 2745-2756.
6. Kim, A.Y., Walinsky, P.L., Kolodgie, F.D., Bian, C., Sperry, J.L., Deming, C.B., Peck, J.G., Ang, G.B., Sohn, R.S., Esmon, C.T., Virmani, R., Stuart, R.S. and Rade, J.J. (2002) "Early loss of thrombomodulin expression impairs vein graft thrombo-resistance: Implications for vein graft failure", Circ. Res. 90, 205-212.
7. Kurosawa, S., Steams, D.J., Jackson, K.W. and Esmon, C.T. (1988) "A 10-kDA cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site", J. Biol. Chem. 263, 5993-5996.
8. Laszik, Z.G., Zhou, X.J., Ferrell, G.L., Silva, F.G. and Esmon, C.T. (2001) "Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis", Am. J. Pathol. 159, 797-802.
9. Letunic, I., Goodstadt, L., Dickens, N.J., Doerks, T., Schultz, J., Mott, R., Ciccarelli, F., Copley, R.R., Ponting, C.P. and Bork, P. (2002) "Recent improvements to the SMART domain-based sequence annotation resource", Nucleic Acid Res. 30, 242-244.
10. Motwani, J.G. and Topol, E.J. (1998) "Aortocoronary saphenous vein graft disease", Circulation 97, 916-931.
11. Richter, K.K., Fink, L.M., Hughes, B.M., Sung, C-C. and Hauer-Jensen, M. (1997) "Is the loss of thrombomodulin involved in the mechanism of chronicity in late radiation enteropathy?", Radiother. Oncol. 44, 65-71.
12. Salom, R.N., Maguire, J.A. and Hancock, W.W. (1998) "Endothelial activation and cytokine expression in human acute cardiac allograft rejection", Pathology 30, 24-29.
13. Stearns, D.J., Kurosawa, S. and Esmon, C.T. (1989) " Microthrombomodulin: Residues, 310-486 from the epidermal growth factor precursor homology domain of thrombomodulin will accelerate protein C activation", J. Biol. Chem. 264, 3352-3356.
14. Suzuki, K., Kusumoto, H., Deyashiki, Y., Nishioka, J., Maruyama, I., Zushi, M., Kawahara, S., Honda, G., Yamamoto, S. and Horiguchi, S. (1987) "Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation", EMBO J. 6, 1891-1897.