Nervous control of the cerebrovascular system: Doubts and facts

Neurochemistry International

Volumn 35, Issue 3, 1999, Pages 237-259

  Sándor, Péter ^a  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ANGIOTENSIN; CATECHOLAMINE DERIVATIVE; CHOLECYSTOKININ; DOPAMINE; HISTAMINE; NEUROKININ; NEUROPEPTIDE; NEUROTENSIN; NEUROTRANSMITTER; NITRIC OXIDE; NORADRENALIN; OPIATE PEPTIDE; RECEPTOR; SEROTONIN; SOMATOSTATIN; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADRENERGIC STIMULATION; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN CIRCULATION; BRAIN METABOLISM; HUMAN; NERVE CELL NETWORK; NERVE POTENTIAL; NEUROTRANSMISSION; PRIORITY JOURNAL; REVIEW; SYNAPTIC TRANSMISSION;

ANIMALS; CEREBROVASCULAR CIRCULATION; HUMANS; NERVOUS SYSTEM PHYSIOLOGY; NEUROTRANSMITTER AGENTS;

EID: 0344654742     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(99)00067-4     Document Type: Review

References (303)

1. Alen J.M., Schon F., Todd N., Yeats J.C., Crockard H.A., Bloom S.R. Presence of neuropeptide Y in human circle of Willis and its possible role in cerebral vasospasm. Lancet. 1:1984;550-552.
2. Armstead W.M., Mirro R.C., Leffler C.W., Busija D.W. Acetylcholine produces cerebrovascular constriction through activation of muscarinic-1 receptors in the newborn pig. Journal of Pharmacology and Experimental Therapeutics. 247:1988;926-933.
3. Armstead W.M., Mirro R.C., Busija D.W., Leffler C.W. Permissible role of prostanoids in acetylcholine-induced cerebral vasoconstriction. Journal of Pharmacology and Experimental Therapeutics. 251:1989;1012-1019.
4. Armstead W.M., Mirro R., Leffler C.W., Busija D.W. Vascular responses to vasopressin are tone-dependent in the cerebral circulation of the newborn pig. Circulation Research. 64:1989;136-144.
5. Armstead W.M., Mirro R., Busija D.W., Leffler C.W. Prostanoids modulate opioid cerebrovascular responses in newborn pigs. Journal of Pharmacology and Experimental Therapeutics. 255:1990;1083-1089.
6. Armstead W.M., Mirro R., Busija D.W., Desiderio D.M., Leffler C.W. Opioids in cerebrospinal fluid in hypotensive newborn pigs. Circulation Research. 68:1991;922-929.
7. Armstead W.M., Mirro R., Busija D.W., Leffler C.W. Opioids and the prostanoid system in the control of cerebral blood flow in hypotensive piglets. Journal of Cerebral Blood Flow and Metabolism. 11:1991;380-387.
8. Armstead W.M., Mirro R., Zuckerman S., Busija D.W., Leffler C.W. The influence of opioids on local cerebral glucose ultilization in the newborn pig. Brain Research. 571:1992;97-102.
9. Armstead W.M., Mirro R., Zukerman S., Leffler C.W. Vasopressin modulates cerebrovascular responses to opioids in newborn pigs. Journal of Pharmacology and Experimental Therapeutics. 260:1992;1107-1112.
10. Armstead W.M., Mirro R., Shibata M., Leffler C.W. Postanoids modulate opioid-induced increases in cerebrospinal fluid vasopressin concentration. American Journal of Physiology. 263:1992;H1670-H1674.
11. Armstead W.M., Crofton J.T., Share L., Mirro R.C., Zuckerman S.L., Leffler C.W. Influence of opioids on CSF vasopressin concentration in newborn pigs. American Journal of Physiology. 262:1992;H862-H867.
12. Armstead W.M., Kurth C.D. The role of opioids in newborn pig fluid percussion brain injury. Brain Research. 660:1994;19-26.
13. Armstead W.M. Opioids and nitric oxide contribute to hypoxia-induced pial arterial vasodilation in newborn pigs. American Journal of Physiology. 268:1995;H226-H232.
14. Armstead W.M. Relationship between opioids and activation of phospholipase C and protein kinase C in brain injury induced pial artery vasoconstriction. Brain Research. 689:1995;183-188.
15. 2-opioid receptors to hypoxia-induced pial artery dilation in the newborn pig. Journal of Cerebral Blood Flow and Metabolism. 15:1995;539-546.
16. Armstead W.M. Role of vasopressin in altered pial artery respones to dynorphin and β-endorphin following brain injury. Journal of Neurotrauma. 13:1996;115-123.
17. Arneric S.P., Iadecola C., Underwood M.D., Reis D.J. Local cholinergic mechanisms participate in the increase in cortical cerebral blood flow elicited by electrical stimulation of the fastigial nucleus in rat. Brain Research. 411:1987;212-225.
18. Aronson H. Über Nerven und Nervendigungen in der Pia Mater. Zeitschrift für Medizinisce Wissenschaft. 28:1890;594-595.
19. 2-adrenoceptor mediates norepinephrine constriction of porcine pial veins. American Journal of Physiology. 263:1992;H1907-H1910.
20. Aubineau P., Sercombe R., Seylaz J. Parasympathetic influence of carbachol on local cerebral blood flow in rabbits by a direct vasodilator action and an inhibition of the sympathetic mediated vasoconstriction. British Journal of Pharmacology. 68:1980;449-459.
21. Auer L.M., MacKenzie E.T. Physiology of the cerebral venous system. Kapp J.P., Scimek H.H. The Cerebral Venous System and its Disorders. 1984;169-227 Grune and Stratton, New York.
22. Bauknight G.C. Jr, Faraci F.M., Heistad D.D. Endothelium-derived relaxing factor modulates noradrenergic constriction of cerebral arterioles in rabbits. Stroke. 23:1992;1522-1526.
23. Baumbach G.L., Heistad D.D. Effects of sympathetic stimulation and changes in arterial pressure in segmental resistance of cerebral vessels in rabbits and cats. Circulation Research. 52:1983;527-533.
24. Benedikt M. Über die Innervation des Plexus Chorioideus Inferior. Virchows Archives für Pathologie, Anatomie und Physiologie. 59:1874;395-400.
25. Bentue-Ferrer D., Reymann J.M., Bagot H., Van den Driesche J., de Certaines J., Allain H. Aminergic neurotransmitter and water content changes in rats after transient forebrain ischeamia. Journal of Neurochemistry. 47:1986;1672-1677.
26. Benyó Z., Wahl M. Opiate receptor mediated mechanisms in the regulation of cerebral blood flow. Cerebrovascular and Brain Metabolism Reviews. 8:1996;326-357.
27. Bevan J.A., Su C. Variation of intra- and perisympathetic adrenergic transmitter concentrations with width of synaptic cleft in vascular tissue. Journal of Pharmacology and Experimental Therapeutics. 190:1974;30-38.
28. Bevan J.A., Bevan R.D., Duckles S.P. Adrenergic regulation of vascular smooth muscle. Bohr D.F., Somlyo A.P., Sparks H.V. Handbook of Physiology: The Cardiovascular System. vol. II:1980;515-566 American Physiological Society, Bethesda.
29. Bevan R.D., Tsuru H., Bevan J.A. Cerebral artery mass in the rabbit is reduced by chronic sympathetic denervation. Stroke. 14:1983;393-396.
30. Bill A., Linder J. Sympathetic control of cerebral blood flow in acute arterial hypertension. Acta Physiologica Scandinavica. 96:1976;114-121.
31. Björklund A., Falck B., Owman C. Fluorescence microscopic and microfluorometric techniques for the cellular localization and characterization of biogenic amines. Berson S.A. Methods of Investigative and Diagnostic Endocrinology. vol. I:1972;318-363 North Holland, Amsterdam.
32. Bonvento G., Lacombe P., Seylaz J. Effects of electrical stimulation of the dorsal raphé nucleus on local cerebral blood flow in the rat. Journal of Cerebral Blood Flow and Metabolism. 9:1989;251-255.
33. Brownstein, M.J., 1993. A brief history of opioid peptides, and opioid receptors. In: Proceedings of the National Academy of Sciences, USA, 90, pp. 5391-5393.
34. Burnstock G. Autonomic neuromuscular junctions: Current developments and future directions. Journal of Anatomy. 146:1986;1-30.
35. Burnstock G. Changes in expression of autonomic nerves in aging and disease. Journal of Autonomic Nervous System. 30:1990;525-534.
36. Burnstock G. Historical and conceptual perspective of the autonomic nervous system book series. Bennett T., Gardiner S.M. Nervous Control of Blood Vessels. The Autonomic Nervous System. vol. 8:1996;7-12 Harwood Academic Publishers, UK.
37. Busija D.W., Marcus M.L., Heistad D.D. Pial artery diameter and blood flow velocity during sympathetic stimulation in cats. Journal of Cerebral Blood Flow and Metabolism. 2:1980;363-367.
38. Busija D.W., Heistad D.D. Atropine does not attenuate cerebral vasodilatation during hypercapnia. American Journal of Physiology. 242:1982;H683-H687.
39. Busija D.W., Marcus M.L., Heistad D.D. Pial artery diameter and blood flow velocity during sympathetic stimulation in cats. Journal of Cerebral Blood Flow and Metabolism. 2:1982;363-367.
40. Busija D.W. Sympathetic nerves reduce cerebral blood flow during hypoxia in awake rabbits. American Journal of Physiology. 247:1984;H446-H451.
41. Busija D.W., Heistad D.D. Effects of activation of sympathetic nerves on cerebral blood flow during hypercapnia in cats and rabbits. Journal of Physiology (London). 347:1984;35-45.
42. Busija D.W., Heistad D.D. Factors involved in physiological regulation of cerebral blood flow. Review of Physiology, Biochemistry and Pharmacology. 101:1984;161-211.
43. Busija D.W., Leffler C.W., Vagerle L.C. Responses of newborn pig pial arteries to sympathetic nervous stimulation and exogenous noradrenaline. Pediatric Research. 19:1985;1210-1214.
44. Busija D.W. Sustained cerebral vasoconstriction during bilateral sympathetic stimulation in anaesthetized rabbits. Brain Research. 345:1985;341-344.
45. Busija D.W., Leffler C.W. Eicosanoid synthesis elicited by norepinephrine in piglet parietal cortex. Brain Research. 403:1987;243-248.
46. 2-adrenoceptors in pial arteries of anaesthetized newborn pigs. Developmental Pharmacology and Therapeutics. 10:1987;36-46.
47. 2-adrenoceptors in newborn pigs. Journal of Cerebral Blood Flow and Metabolism. 7:1987;184-188.
48. Busija D.W., Leffler C.W. Dilator effects of amino acid neurotransmitters on piglet pial arterioles. American Journal of Physiology. 26:1989;H1200-1203.
49. Busija D.W., Leffler C.W. Effects of dopamine on pial arteriolar diameter and CSF prostanoid levels in piglets. Journal of Cerebral Blood Flow and Metabolism. 9:1989;264-267.
50. Busija D.W., Leffler C.W., Vagerle L.C. Mono L-arginine-containing compounds dilate piglet pial arterioles via endothelium-derived relaxing factor-like substance. Circulation Research. 67:1990;1374-1380.
51. Busija D.W., Chen J. Effects of trigeminal neurotransmitters in piglet pial arterioles. Journal of Developmental Physiology. 263:1992;H1455-H1459.
52. Busija D.W. Nervous control of the cerebral circulation. Bennett T., Gardiner S.M. Nervous Control of Blood Vessels. The Autonomic Nervous System. vol. 8:1996;177-205 Harwood Academic Publishers, UK.
53. Cervós-Navarro J., Matakas F. Electron microscopic evidence for innervation of intracerebral arterioles in the cat. Neurology. 24:1974;282-286.
54. Chan-Palay V. Serotonin axons in the supra- and sub-ependymal plexuses and in the leptomeninges, their roles in local alterations of cerebrospinal and vasomotor activity. Brain Research. 102:1976;103-130.
55. Chan-Palay V. Innervation of cerebral blood vessels by norepinephrine, indoleamine, substance P and neurotensin fibers and the leptomeningeal indoleamine axons: their roles in vasomotor activity and local alteration of brain blood composition. Owman C., Edvinson L. Neurogenic Control of the Brain Circulation. 1977;39-53 Pergamon Press, Oxford.
56. Chang J.Y., Ekblad E., Kannisto P., Owman C. Serotonin uptake into cerebrovascular nerve fibers of rat, visualization by immunohistochemistry, disappearance following sympathectomy and release during electrical stimulation. Brain Research. 492:1989;79-88.
57. Childers S.R. Opioid receptor-coupled second messenger systems. Life Sciences. 48:1991;375-380.
58. Chorobski J., Penfield W. Cerebral vasodilator nerves and their pathway from the medulla oblongata. Archives of Neurology and Psychiatry. 28:1932;1257-1289.
59. Clark S.L. Innervation of the blood vessels of the medulla and spinal cord. Journal of Comparative Neurology. 48:1929;247-265.
60. Cobb S. Cerebral circulation: a critical discussion of the symposium. Res. Pub. Assoc. Res. Nerv. Ment. Dis. 18:1938;719-752.
61. Coghill R.C., Sang C.N., Berman K.F., Bennett G.J., Jadaraola M.J. Global cerebral bloodflow decreases during pain. Journal of Cerebral Blood Flow and Metabolism. 18:1998;141-147.
62. Colonna D.M., Meng W., Deal D.D., Busija D.W. Calcitonin gene-related peptide promotes cerebrovascular dilation during spreading depression in rabbits. American Journal of Physiology. 266:1994;H1095-H1102.
63. Dacey R.G., Basett J.E., Takayasu M. Vasomotor responses of rat intracerebral arterioles to vasoactive intestinal peptide, substance P, neuropeptide Y, and bradykinin. Journal of Cerebral Blood Flow and Metabolism. 8:1988;254-261.
64. Dahl E., Nelson E. Electron microscopic observations on human intracranial arteries II. Innervation. Archives of Neurology. 10:1964;158-164.
65. Dahl E. The innervation of the cerebral arteries. Journal of Anatomy. 115:1973;53-63.
66. Dahlgren L., Lindvall O., Sakabe T., Steneni U., Siesjö B.K. Cerebral blood flow and oxygen consumption in the rat brain after lesions of the noradrenergic locus coeruleus system. Brain Research. 209:1981;11-23.
67. Deli M., Bajenaru L., Maderspach K., Joó F. Kappa-opioid receptors in cultured cerebral endothelial cells. Neurochemistry International. 21:1992;C3.
68. Devine J.O., Armstead W.M. The role of nitric oxide in opioid-induced pial artery vasodilation. Brain Research. 675:1995;257-263.
69. Dirnagl U. Metabolic aspects of neurovascular coupling. Advances in Experimental Medicine and Biology. 413:1997;149-153.
70. Doba N., Reis D.J. Changes in regional blood flow and cardiodynamics evoked by electrical stimulation of the fastigial nucleus in cat and their similarity to orthostatic reflexes. Journal of Physiology (London). 237:1972;729-747.
71. Duckles S.P., Buck S.H. Substance P in the cerebral vasculature: Depletion by capsaicin suggests a sensory role. Brain Research. 245:1982;171-174.
72. Eckenstein F., Baughman R.W. Two types of cholinergic innervation in cortex, one colocalized with vasoactive intestinal polypeptide. Nature. 309:1984;153-155.
73. Edvinsson L., Nielsen K.C., Owman C., Sporrong B. Cholinergic mechanisms in pial vessels. Histochemistry, electron microscopy and pharmacology. Zeitschrift für Zellforschung. 134:1972;311-325.
74. Edvinsson L., Lindvall M., Nielsen K.C., Owman C. Are brain vessels innervated also by central (non-sympathetic) adrenergic neurons? Brain Research. 63:1973;396-399.
75. Edvinsson L., MacKenzie E.T. Amine mechanisms in the cerebral circulation. Pharmacological Reviews. 2:1976;275-348.
76. Edvinsson L., Owman C., Siesjö B. Physiological role of cerebrovascular sympathetic nerves in the autoregulation of cerebral blood flow. Brain Research. 117:1976;519-523.
77. Edvinsson L., Falck B., Owman C. Possibilities for a cholinergic action on smooth musculature and on sympathetic axons in brain vessels mediated by muscarinic and nicotinic receptors. Journal of Pharmacology and Experimental Therapeutics. 200:1977;117-126.
78. Edvinsson L., Cervós-Navarro J., Larson L-I., Owman C., Rönberg A-L. Regional distribution of mast cells containing histamine, dopamine, or 5-hydroxytriptamine in the mammalian brain. Neurology. 27:1977;878-883.
79. Edvinsson L., Owman C. Sympathetic innervations and adrenergic receptors in intraparenchymal cerebral arteries of baboon. Ingvar D.H., Lassen N.A. Proceedings of the 8th International Symposium on Cerebral Function, Metabolism and Circulation, Munksgaard, Copenhagen. 1977;403-405.
80. Edvinsson L., Hardebo J.E., McCulloch J., Owman C. Effets of dopaminergic agonists and antagonists on isolated cerebral blood vessels. Acta Physiologica Scandinavica. 104:1978;349-359.
81. Edvinsson L., McCulloch J., Uddman R. Substance P: immunohistochemical localization and effect upon cat pial arteries in vitro and in situ. Journal of Physiology (London). 318:1981;251-258.
82. Edvinsson L. Sympathetic control of cerebral circulation. Trends in Neurosciences. 5:1982;425-428.
83. Edvinsson L., McCulloch J., Uddman R. Feline cerebral veins and arteries: comparison of autonomic innervation and vasomotor responses. Journal of Physiology. 325:1982;161-173.
84. Edvinsson L., Emson P., McCulloch J., Tatemoto K., Uddman R. Neuropeptide Y: cerebrovascular innervation and vasomotor effects in the cat. Neuroscience Letters. 43:1983;79-84.
85. Edvinsson L., Degueurce A., Duverger D., MacKenzie E.T., Scatton B. Central serotonergic nerves project to the pial vessels of the brain. Nature. 306:1983;55-57.
86. Edvinsson L., Emson P., McCulloch J., Tatemoto K., Uddman R. Neuropeptide Y: Immunocytochemical localization to and effect upon feline pial arteries and veins in vitro and in situ. Acta Physiologica Scandinavica. 122:1984;155-163.
87. Edvinsson L., Degueurce A., Duverger D., MacKenzie E.T., Scatton B., Uddman R. Coupling between cerebral blood flow and metabolism: A role for serotonin? MacKenzie E.T., Bes A., Seylaz J. Neurotransmitters and the Cerebral Circulation. 1984;121-136 Raven Press, New York.
88. Edvinsson L., Birath E., Uddman R., Lee T.J-F., Duverger D., MacKenzie E.T., et al. Indoleaminergic mechanisms in brain vessels: localization, concentrations, uptake and in vitro response of 5-hydroxytryptamine. Acta Physiologica Scandinavica. 121:1984;291-299.
89. Edvinsson L., Fredholm B.B., Hamel E., Jansen I., Verrechia C. Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat. Neuroscience Letters. 58:1985;213-217.
90. Edvinsson L., Uddman R., Juul R. Peptidergic innervation of the cerebral circulation. Role in subarachnoid hemorrhage in man. Neurosurgical Review. 13:(4):1990;265-272.
91. Edvinsson L., Stack E.J., Trizna W. Calcitonin-gene related peptide stimulates adenylate cyclase and relaxes intracerebral arterioles. Journal of Pharmacology and Experimental Therapeutics. 257:1991;1020-1024.
92. Edvinsson L., MacKenzie E.T., McCulloch J. Cerebral Blood Flow and Metabolism. 1993;Raven Press, New York.
93. Edwards R.M., Stack E.J., Trizna W. Calcitonin gene related peptide stimulates adenylate cyclase and relaxes intracerebral arterioles. Journal of Pharmacology and Experimental Therapeutics. 257:1991;1020-1024.
94. Ekblad E., Edvinsson L., Walestedt C., Uddman R., Hakanson R., Sudler F. Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers. Regulatory Peptides. 8:1984;225-235.
95. Falck B., Mchedlishvili G-I., Owmann C. Histochemical demonstration of adrenergic nerves in cortex-pia of rabbits. Acta Pharmacologica Toxicologica. 23:1965;133-142.
96. Fallgren B., Ekblad E., Edvinsson L. Co-existence of neuropeptide and differential inhibition of vasodilator responses by neuropeptide Y in guinea-pig uterine arteries. Neuroscience Letters. 100:1989;71-76.
97. Faraci F.M., Brian J.E. Nitric oxide and the cerebral circulation. Stroke. 25:1994;692-703.
98. Felten D.J., Crutcher K.A. Neuronal-perivascular relationships in the raphe nuclei, locus coeruleus and substantia nigra in primates. American Journal of Anatomy. 155:1979;467-482.
99. Florence V.M., Bevan J.A. Biochemical determinations of cholinergic innervations in cerebral arteries. Circulation Research. 45:1979;212-218.
100. Foster C., Drew G.M., Holdditch A., Whalley E.T. Dopamine receptors in human basilar arteries. European Journal of Pharmacology. 87:1983;227-235.
101. Furchgott R.F. The role of endothelium in responses of vascular smooth muscle to drugs. Annual Review of Pharmacology and Toxicology. 24:1984;175-197.
102. Gibbins I.L., Brayden J.E., Bevan J.A. Perivascular nerves with immunoreactivity to vasoactive intestinal polypeptide in cephalic arteries of the cat: distribution, possible origins and functional implications. Neuroscience. 13:1984;1327-1346.
103. Gibbins I.L., Morris J.L. Co-existence of neuropeptides in sympathetic, cranial and sensory neurons innervating the iris of the guinea-pig. Journal of Autonomic Nervous System. 21:1987;67-82.
104. Gibbins I.L., Morris J.L. Co-existence of immunoreactivity to neuropeptide Y and vasoactive intestinal peptide in non-noradrenergic axons innervating guinea-pig cerebral arteries after sympathectomy. Brain Research. 444:1988;402-406.
105. Golanov E.V., Reis D.J. Nitric oxide and prostanoids participate in cerebral vasodilatation elicited by electrical stimulation of the rostral ventrolateral medulla. Journal of Cerebral Blood Flow and Metabolism. 14:1994;492-502.
106. Goadsby P.J., Edvinsson L. Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies. Brain. 117:(3):1994;427-434.
107. Gonzalez C., Estrada C. Nitric oxide mediates the neurogenic vasodilation of bovine cerebral arteries. Journal of Cerebral Blood Flow and Metabolism. 11:1991;366-370.
108. Griffith S.G., Lincoln J., Burnstock G. Serotonin as a neurotransmitter in cerebral arteries. Brain Research. 247:1982;388-392.
109. Griffith S.G., Burnstock G. Immunohistochemical demonstration of serotonin in nerves supplying human cerebral and mesenteric blood vessels. Lancet. 1:1983;561-562.
110. Gross P.M., Harper A.M., Teasdale G.M. Interaction of histamine with noradrenergic constrictory mechanisms in cat cerebral arteries and veins. Canadian Journal of Physiology and Pharmacology. 61:1983;756-763.
111. Guyton A.C. Textbook of Medical Physiology. 4th ed. 1971;Saunders, Philadelphia.
112. Hagberg H., Andersson P., Kjellmer I., Thiringer K., Thordstein M. Extracellular overflow of glutamate, aspartate, GABA and taurine in the cortex and basal ganglia of fetal lambs during hypoxia-ischaemia. Neuroscience Letters. 78:1987;311-317.
113. Hamel E., Edvinsson L., MacKenzie E.T. Heterogenous vasomotor responses of anatomically distinct feline cerebral arteries. British Journal of Pharmacology. 94:1988;423-436.
114. Hanko J., Hardebo J.E., Owman C. Effects of various neuropeptides on cerebral blood vessels. Journal of Cerebral Blood Flow and Metabolism. 1:1981;S346-S347.
115. Hara H., Jansen I., Ekman R., Hamel E., MacKenzie E.T., Uddman R., et al. Acetylcholine and vasoactive intestinal peptide in cerebral blood vessels: Effect of extirpation of the sphenopalatine ganglion. Journal of Cerebral Blood Flow and Metabolism. 9:1989;204-211.
116. Hardebo J.E., Edvinsson L., Emson P.G., Owman C. Isolated brain microvessels: enzymes related to adrenergic and cholinergic functions. Owman C., Edvinsson L. Neurogenic Control of the Brain Circulation. 1977;105-113 Pergamon Press, Oxford.
117. Harder D.R., Madden J.A. Cellular mechanisms of opiate receptor stimulation in cat middle cerebral artery. European Journal of Pharmacology. 102:1984;411-416.
118. Harper A.M., Deshmukh V.D., Rowan J.O., Jennett W.B. The influence of sympathetic nervous activity on cerebral blood flow. Archives of Neurology. 27:1972;1-6.
119. Hart M., Heistad D.D., Brody M.J. Effect of chronic hypertension and sympathetic devervation on wall-lumen ratio of cerebral arteries. Hypertension. 2:1980;419-423.
120. Hartman, B.K., Zide, D., Udenfriend, D., 1972. The use of dopamine B hydroxylase as a marker for the central noradrenergic nervous system in rat brain. In: Proceedings of the National Academy of Sciences, USA, 69, pp. 2722-2726.
121. Hayashi S., Park M.K., Kuehl T.J. Higher sensitivity of cerebral arteries isolated from premature and newborn baboons to adrenergic and cholinergic stimulation. Life Sciences. 35:1984;253-260.
122. Hayashi S., Park M.K., Kuehl T.J. Post-synaptic α-adrenoreceptors in baboon cerebral and mesenteric arteries. Journal of Pharmacology and Experimental Therapeutics. 235:1985;113-121.
123. Head R.J., Hjelle J.T., Jarrott B., Berkowitz B., Cardinale G., Spector S. Isolated brain microvessels: Preparation, morphology, histamine and catecholamine contents. Blood Vessels. 17:1980;173-186.
124. Heistad D.D., Marcus M.L., Sandberg S., Abbouod F.M. Effect of sympathetic nerve stimulation on cerebral blood flow and on large cerebral arteries of dogs. Circulation Research. 41:1977;342-350.
125. Heistad D.D., Marcus M.L. Evidence that the neural mechanisms do not have important effects on cerebral blood flow. Circulation Research. 42:1978;295-302.
126. Heistad D.D., Marcus M.L., Gross P.M. Effects of sympathetic nerves on cerebral vessels in dog, cat and monkey. American Journal of Physiology. 235:1978;H544-H522.
127. Heistad D.D., Marcus M.L. Effect of sympathetic stimulation on permeability of the blood-brain barrier to albumin during acute hypertension in cats. Circulation Research. 45:1979;331-338.
128. Heistad D.D., Busija D.W., Marcus M.L. Neural effects on cerebral vessels: alteration of pressure-flow relationship. Federation Proceedings. 40:1981;2317-2321.
129. Heistad D.D., Marcus M.L. Cerebral Blood Flow: Effect of Nerves and Neurotransmitters. 1982;Elsevier, New York.
130. Hillarp N-A. The construction and functional organisation of the autonomic innervation apparatus. Acta Physiologica Scandinavica. 46:(157):1959;1-38.
131. Hüber G.C. Observations on the innervation of intracranial vessels. Journal of Comparative Neurology. 9:1899;1-34.
132. Högestatt E.D., Andersson K-E. On the postjunctional α-adrenoreceptors in rat cerebral and mesenteric arteries. Journal of Autonomic Pharmacology. 4:1984;161-175.
133. Hong K.W., Pyo K.M., Lee W.S., Yu S.S., Rhim B.Y. Pharmacological evidence that calcitonin gene-related peptide is implicated in cerebral autoregulation. American Journal of Physiology. 266:1994;H11-H16.
134. Iadecola C., Lacombe P.M., Underwood M.D., Ishitsuka T., Reis D.J. Role of adrenal catecholamines in cerebrovasodilation evoked from brain stem. American Journal of Physiology. 21:1987;H1183-H1191.
135. Iadecola C., Reis D.J. Continuous monitoring of cerebrocortical blood flow during stimulation of the cerebellar fastigial nucleus: a study by laser-doppler flowmetry. Journal of Cerebral Blood Flow and Metabolism. 10:1990;608-617.
136. Iadecola, C., 1992. Does nitric oxide mediate increases in cerebral blood flow elicited by hypercapnia?. In: Proceedings of the National Academy of Sciences, USA, 89, pp. 3913-3916.
137. Iadecola C., Zhang F. Nitric oxide-dependent and independent components of cerebrovasodilation elicited by hypercapnia. American Journal of Physiology. 266:1994;R546-R552.
138. Iwayama T., Furness J.B., Burnstock G. Dual adrenergic and cholinergic innervation of the cerebral arteries of the rat. An ultrastructural study. Circulation Research. 26:1970;635-646.
139. Johansson O., Hökfelt T., Elde R.P. Immunohistochemical distribution of somatostatin-like immunoreactivity in the central nervous system of the adult rat. Neuroscience. 13:1984;265-339.
140. Kapadia S.E., de Lanerolle N.C. Immunohistochemical and electron microscopic demonstration of vascular innervation in the mammalian brainstem. Brain Research. 292:1984;33-39.
141. Kendrick K.M., Keverne E.B., Chapman C., Baldwin B.A. Microdialysis measurement of oxytocin, apartate, d-amino-butyric acid and glutamate release from the olfactory bulb of the sheep during vaginocervical stimulation. Brain Research. 442:1988;171-174.
142. Kitazano T., Heistad D.D., Faraci F.M. Role of ATP-sensitive K channels in CGRP-induced dilatation of basilar artery in vivo. American Journal of Physiology. 265:1993;H581-H585.
143. Knapp, R.J., Malatynska, E., Collins, N. et al. 1995 Molekular biology and pharmacology of cloned opioid receptors. 9, 516-25.
144. Kobayashi S., Tsukahara S., Sugita K., Nagata T. Adrenergic and cholinergic innervation of rat cerebral arteries. Histochemistry. 70:1981;129-138.
145. Komjáti K., Harvich-Velkei M., Toth J., Dallos G., Nyáry I., Sándor P. Endogenous opioid mechanisms in hypothalamic blood flow autoregulation during hemorrhagic hypotension and angiotensin-induced acute hypertension in cats. Acta Physiologica Scandinavica. 157:1996;53-61.
146. Komjáti K., Dallos G., Velkei M.H., Sándor P. Regionally different effects of centrally induced opiate receptor blockade on cerebral blood flow autoregulation in cats. Pfluegers Archive, European Journal of Physiology. 434:1997;144-146.
147. Komjáti K., Sándor P., Sándor N., Szirmai L., Velkei H.M., Kovách A.G.B. Cerebrocortical and medullary blood flow changes after general opiate receptor blockade during hemorrhagic shock in cats. Shock. 7:(4):1997;289-294.
148. Kontos H.A. Regulation of the cerebral circulation. Annual Review of Physiology. 43:1981;397-407.
149. Kontos H.A., Wei E.P. Hydroxyl radical-dependent inactivation of guanylate cyclase in cerebral arterioles by methylene blue and by LY83583. Stroke. 24:1993;427-434.
150. Kovach A.G.B., Sándor P. Cerebral blood flow and brain function during hypotension and shock. Annual Review of Physiology. 39:1976;571-596.
151. Kovach A.G.B., Szabó Cs, Benyó Z., Csáki Cs, Greenberg J.H., Reivich M. Effect of NG-nitro-L-arginine and L-arginine on regional cerebral blood flow in the cat. Journal of Physiology (London). 449:1992;183-196.
152. Kurosawa M., Sato A., Sato Y. Well maintained responses of acetylcholine release and blood flow in the cerebral cortex to local electrical stimulation of the nucleus basalis Meynert in the aged rats. Neuroscience Letters. 100:1989;198-202.
153. Kurth C.D., Wagerle L.C., Delivoria-Papadopoulos M. Sympathetic regulation of cerebral blood flow during seizures in newborn lambs. American Journal of Physiology. 24:1988;H563-H568.
154. Kuschinsky W., Wahl M., Neiss A. Evidence for cholinergic dilatory receptors in pial arteries in cats. Pfluegers Archives. 347:1974;199-208.
155. Kuschinsky W., Wahl M. α-receptor stimulation by endogenous and exogenous noradrenaline and blockade by phentolamine in pial arteries in cats. A microapplication study. Circulation Research. 37:1975;168-174.
156. Kuschinsky W., Wahl M. Local chemical and neurogenic regulation of cerebral vascular resistance. Physiological Reviews. 58:1978;656-689.
157. Lacombe P.M., Iadecola C., Underwood M.D., Sved A.F., Reis D.J. Plasma epinephrine modulates the cerebrovasodilation evoked by electrical stimulation of the dorsal medulla. Brain Research. 506:1990;93-100.
158. Lai, F.M., Udenfriend, S., Spector, S., 1975. Presence of norepinephrine and related enzymes in isolated brain microvessels. In: Proceedings of the National Academy of Sciences, USA, 72, pp. 4622-4625.
159. Lande I.S., Cannell V.A., Waterson J.G. The interaction of serotonin and noradrenaline on the perfused artery. British Journal of Pharmacology. 28:1966;255-272.
160. Larson L.I., Edvinsson L., Fahrenkrug J., Hakanson R., Owman Ch, Schaffalitzky de Muckadel O.B., et al. Immunohistochemical localization of a vasodilatory polypeptide (VIP) in cerebrovascular nerves. Brain Research. 113:1976;400-404.
161. Lee T.J-F. Ultrastructural distribution of vasodilator and constrictor nerves in cat cerebral arteries. Circulation Research. 49:1981;971-979.
162. Lee T.J-F., Kinkhead L.R., Sarwinski S. Noradrenaline and acetylcholine transmitter mechanism in large cerebral arteries of the pig. Journal of Cerebral Blood Flow and Metabolism. 2:1982;439-450.
163. Lee T.J-F., Saito A., Berezin I. Vasoactive intestinal polypeptide-like substance: The potential transmitter for cerebral vasodilation. Science. 22:(4):1984;898-901.
164. Lee T.J-F. Cholinergic interactions and vascular smooth muscle tone. Grover A.K., Daniel E.E. Calcium and Contractility. 1985;351-383 The Humana Press, Bethesda, MD.
165. Lee T.J-F., Sarwinski S. Nitric oxidergic neurogenic vasodilation in porcine basilar artery. Blood Vessels. 28:1991;407-412.
166. Lembeck F., Holzer P. Substance P as neurogenic mediator of antidromic vasodilatation and neurogenic plasma extravasation. Naunyn-Schmiedeberg's Archives of Pharmacology. 310:1979;175-183.
167. Liu-Chen L-Y., Han D.H., Moskowitz M.A. Pial arachnoid contains substance P originating from trigeminal neurons. Neuroscience. 9:1983;803-838.
168. Liu-Chen L-Y., Gillespie S.A., Norregaard T.V., Go V.L.W., Moskowitz M.A. Cholecystokinin-8 (CCK8) immunoreactivity in cerebral arteries and pial arachnoid and the effect of unilateral trigeminal ganglionectomy. Federation Proceedings. 43:1983;304. (abstract).
169. Liu-Chen L-Y., Mayberg M.R., Moskowitz M.A. Immunohistochemical evidence for a substance P-containing trigeminovascular pathway to pial arteries in cats. Brain Research. 268:1983;162-166.
170. Liu-Chen L-Y., Gillespie S.A., Norregaard T.V., Moskowitz M.A. Co-localization of retrogradely transported wheat germ agglutinin and the putative neurotransmitter substance P within trigeminal ganglion cells projecting to cat middle cerebral artery. Journal of Comparative Neurology. 225:1984;187-192.
171. Lluch S., Reinmann C., Glick G. Evidence for the direct effect of adrenergic drugs on the cerebrovascular bed in unanesthetized goat. Stroke. 4:1973;50-56.
172. Lou H.C., Edvinsson L., MacKenzie E.T. The concept of coupling blood flow to brain function: Revision required? Annals of Neurology. 22:1987;289-297.
173. Macfarlane R., Tasdemiroglu E., Moskowitz M.A., Uemura Y., Wei E.P., Kontos H.A. Chronic trigeminal ganglionectomy or topical capsaicin application to pial vessels attenuates post-occlusive cortical hyperiemia but does not influence post-ischemic hypoperfusion. Journal of Cerebral Blood Flow and Metabolism. 11:1991;261-271.
174. MacKenzie E.T., Strandgaard S., Graham D.I., Jones J.V., Harper A.M., Farrar J.K. Effects of acutely induced hypertension in cats on pial arteriolar caliber, local cerebral blood flow and the blood-brain barrier. Circulation Research. 39:1976;33-41.
175. MacKenzie E.T., McCulloch J., O'Culloch J., O'Keane M., Pickard J.D., Harper A.M. Cerebral circulation and norepinephrine: Relevance of the blood-brain barrier. American Journal of Physiology. 231:1976;483-488.
176. MacKenzie E.T., Scatton B. Cerebral circulatory and metabolic effect of perivascular neurotransmitters. Critical Review of Clinical Neurobiology. 2:1987;367-419.
177. Madden A., Kalbfleisch J.H., Harder D.R. Distribution of excitatory junction potential amplitude in cat cerebral arteries: examination of its
178. Maeda M., Krieger A.J., Nakai M., Sapru H.N. Chemical stimulation of the rostral ventrolateral medullary pressor area decreases cerebral blood flow in anaesthetized rats. Brain Research. 563:1991;261-269.
179. Maeda M., Duelli R., Schröck H., Kuschinsky W. Autoradiographic determination of local cerebral blood flow and local cerebral glucose utilization during chemical stimulation of the nucleus tractus solitarii of anesthetized rats. Journal of the Autonomic Nervous System. 69:1998;132-140.
180. Malonek, D., Dirnagl, U., Lindauer, U., Yamada, K., Kanno, I., 1997. Vascular imprints of neuronal activity: Relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation. In: Proceedings of the National Academy of Sciences, USA, 94, pp. 14826-14831, (Neurobiology).
181. Marcus M.L., Heistad D.D. Effects of sympathetic nerves on cerebral blood flow in awake dogs. American Journal of Physiology. 5:1979;H549-H553.
182. Marcus M.L., Busija D.W., Gross P.M., Brooks L.A., Heistad D.D. Sympathetic escape in the cerebral circulation during normotension and acute severe hypertension. Heistad D.D., Marcus M.L. Cerebral Blood Flow. Effect of Nerves and Neurotransmitters. 1982;281-289 Elsevier, New York.
183. Markowitz S., Saito K., Moskowitz M.A. Neurogenically-mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain. Journal of Neuroscience. 7:1987;4129-4136.
184. Marshall J.J., Wei E.P., Kontos H.A. Independent blockade of cerebral vasodilation from acetylcholine and nitric oxide. American Journal of Physiology. 255:1988;H1847-H1854.
185. Mayberg M.R., Langer R.S., Zervas N.T., Moskowitz M.A. Perivascular meningeal projection from cat trigeminal ganglia: possible pathway for vascular headaches in man. Science. 213:1981;228-230.
186. Mayberg M.R., Zervas N.T., Moskowitz M.T. Trigeminal projections to supratentorial pial and dural blood vessels in cats demonstrated by horseradish peroxidase histochemistry. Journal of Comparative Neurology. 223:1984;46-56.
187. McCalden T.A., Mendelow A.D., Coull A., Scriven D.R.L., Rosendorff C., Eidelman B.H. Role of catecholamine degradative enzymes and the adrenergic innervation in determining the cerebrovascular response to infused norepinephrine. Stroke. 10:1979;319-322.
188. McCalden T.A. Sympathetic control of the cerebral circulation. Journal of Autonomic Pharmacology. 1:1981;421-431.
189. McCulloch J., Edvinsson L. Cerebral circulatory and metabolic effects of vasoactive intestinal polypeptide. American Journal of Physiology. 238:1980;H449-H456.
190. McCulloch J., Kelly P.A.T. Effects of cholecystokinin octapeptide on pial arteriolar diameter. Journal of Cerebral Blood Flow and Metabolism. 4:1984;625-628.
191. McCulloch, J., Uddman, R., Kingman, T., Edvinsson, L., 1986. Calcitonin gene-related peptide: Functional role in cerebrovascular regulation. In: Proceedings of the National Academy of Sciences, USA, 83, pp. 5731-5735.
192. McGrath M.A. 5-Hydroxytryptamine and neurotransmitter release in canine blood vessels. Circulation Research. 41:1977;428-435.
193. McNaughton F.L. The innervation of the intracranial blood vessels and dural sinuses. Research Publications of the Association of Nervous and Mental Diseases. 18:1938;178-200.
194. Medgett I.C., Langer S.Z. Characterization of smooth muscle α-adrenoreceptors and of response to electrical stimulation in the cat isolated perfused middle cerebral artery. Naunyn-Schmiedeberg's Archives of Pharmacology. 323:1983;24-32.
195. Meija J.A., Pernow J., von Holst H., Rudehill A., Lundberg J.M. Effects of neuropeptideY, calcitonin gene-related peptide, substance P, and capsaicin on cerebral arteries in man and animals. Journal of Neurosurgery. 69:1988;913-918.
196. Mirro R., Busija D.W., Armstead W.M., Leffler C.W. Histamine dilates the pial arterioles of newborn pigs through prostanoid production. American Journal of Physiology. 23:1988;H1023-H1026.
197. Mollereau C., Parmentier M., Mailleux P., Butour J.L., Moisand C., Chalon P., Caput D., Vassart G., Meunier J.C. ORL1, a novel member of the opioid receptor family. FEBS Letters. 341:1994;33-38.
198. Molnár L., Szántó J. The effect of electrical stimulation of the bulbar vasomotor centre on the cerebral blood flow. Quarterly Journal of Experimental Physiology. 49:1964;184-190.
199. Molnár L. Sur le controle nerveaux de la circulation sanguine regionale des centres cérebraux. 1967;Akadémiai Kiadó Budapest.
200. Molnár L. Role of brainstem in CBF regulation. Scandinavian Journal of Clinical and Laboratory Investigations. 102:1968;VI:D. (Suppl.).
201. Moreno M.J., Lopez de Pablo A.L., Marco E.J. Tryptophan hydroxylase activity in rat brain base arteries related to innervation originating from the dorsal raphé mucleus. Stroke. 25:1994;1046-1049.
202. Moskowitz M.A., Kuo C., Leeman S.E., Jessen M.E., Derian C.K. Desenzitization to substance P-induced vasodilation in vitro is not shared by endogenous tachikinin neurokinin A. Journal of Neuroscience. 7:1987;2344-2351.
203. Moskowitz M.A., Sakas D.E., Wei E.P., Kano M., Buzzi M.G., Ogilvy C., et al. Postocclusive cerebral hyperemia is markedly attenuated by chronic trigeminal ganglionetomy. American Journal of Physiology. 26:1989;H1736-H1739.
204. Mraovitch S., Pinard E., Seylaz J. Two neural mechanisms in rat fastigial nucleus regulating systemic and cerebral circulation. American Journal of Physiology. 251:1986;H153-H163.
205. Mueller S.M., Heistad D.D., Marcus M.L. Total and regional cerebral blood flow during hypotension, hypertension and hypocapnia: Effect of sympathetic denervation in dogs. Circulation Research. 41:1977;350-356.
206. Murphy S., Minor R.L., Welk G., Harrison D.G. Evidence from an astrocyte-derived vasorelaxing factor with properties similar to nitric oxide. Journal of Neurochemistry. 55:1990;349-351.
207. Nakai M., Iadecola C., Reis D.J. Global cerebral vasodilatation of rat fastigial cerebellar nucleus. American Journal of Physiology. 243:1982;H226-H235.
208. Nakai M., Iadecola C., Ruggiero D.A., Tucker L.W., Reis D.J. Electrical stimulation of cerebellar fastigial nucleus increases cerebrocortical blood flow without change in local metabolism: evidence for an intrinsic system in brain for primary vasodilatation. Brain Research. 260:1983;35-49.
209. Nakakita N., Hiroyuki K., Kogure K. Effects of repeated cerebral ischemia on extracellular amino acid concentration measured with intracerebral microdialysis in the gerbil hyppocampus. Stroke. 24:1993;458-464.
210. Navari R., Wei E.P., Kontos H.A., Patterson J.L. Jr. Comparation of the open skull and cranial window preparations is the study of the cerebral microcirculation. Microvascular Research. 16:1978;304-315.
211. Nelson E., Rennels M. Neuromuscular contacts in intracranial arteries of the cat. Science. 167:1970;301-302.
212. Nelson E., Takayanagi T., Rennels M., Kawamura J. The innervation of human intracranial arteries: A study by scanning and transmisson electron microscopy. Journal of Neuropathology and Experimental Neurology. 31:1972;526-534.
213. Nielsen K.C., Owman C. Adrenergic innervation of pial arteries related to the circle of Willis in the cat. Brain Research. 6:1967;773-776.
214. Nielsen K.C., Owman C., Sporrong B. Ultrastructure of the autonomic innervation apparatus in the main pial arteries of rats and cats. Brain Research. 27:1971;25-32.
215. Norregaard T., Moskowitz M.A. Substance P and the sensory innervation of intracranial and extracranial feline cephalic arteries. Brain. 108:1985;517-533.
216. North R.A. Opioid receptor types and membrane channels. Trends in Neuroscience. 9:1986;114-117.
217. Northington, F.J., Matherne, G.P., Berne, R.M., 1992. Competitive inhibition of nitric oxide synthase prevents the cortical hyperemia associated with peripheral nerve stimulation. In: Proceedings of the National Academy of Sciences, USA, 89, pp. 6649-6652.
218. Nozaki K., Moskowitz M.A., Maynard K.I., Koketsu N., Dawson T.M., Bredt D.S. Possible origins and distribution of immunoreactive nitric oxide synthase-containing nerve fibers is cerebral arteries. Journal of Cerebral Blood Flow and Metabolism. 13:1993;70-79.
219. Oberförster G., Lang R., Zimmer R. Direct effects of the alpha and beta sympathomimetic amines on the cerebral circulation of the dog. Pflugers Archive. 340:1973;145-160.
220. Olesen J. The effect of intracarotid epinephrine, norepinephrine and angiotensin on the regional cerebral blood flow in man. Neurology (Minneapolis.). 22:1972;978-983.
221. Oudart N., Sercombe R., Aubineau P., Boulu R.G., Seylaz J. Relaxation by dopaminergic agonists in cerebral and peripheral arteries (in vitro). Archive of International Pharmacodynamics. 252:1981;196-209.
222. Owman C., Edvinsson L. Neurogenic Control of the Brain Circulation. 1977;Pergamon Press, Oxford.
223. Owman C., Hardebo J.E. Neural Regulation of Brain Circulation. 1986;Elsevier, Amsterdam.
224. Paulson O.B., Strandgaard S., Edvinsson L. Cerebral autoregulation. Cereb. Brain Metab. Rev. 2:1990;161-192.
225. Penfield W. Intracerebral vascular nerves. Archives of Neurology and Psychiatry. 27:1932;30-44.
226. Peerless S.J., Yasargil M.G. Adrenergic innervation of the cerebral blood vessels in the rabbit. Journal of Neurosurgery. 35:1971;148-154.
227. Peroutka S.J., Moskowitz M.A., Reinhard J.F., Snyder S.H. Neurotransmitter receptor binding in bovine cerebral microvessels. Science. 208:1980;610-612.
228. Ponte J., Purves M.J. The role of the carotid body chemoreceptors and carotid sinus baroreceptors in control of cerebral blood vessels. Journal of Physiology. 237:1974;315-340.
229. Purdy R.E., Bevan J.A. Adrenergic innervation of large cerebral blood vessels of the rabbit studied by fluorescence microscopy: Absence of features that might contribute to non-uniform change in cerebral blood flow. Stroke. 8:1977;82-87.
230. Purves M.J., James I.M. Observations on the control of cerebral blood flow in the sheep fetus and newborn lamb. Circulation Research. 25:1969;651-667.
231. Purves M.J. The Physiology of the Cerebral Circulation. 1972;Cambridge University Press, Cambridge, UK.
232. Purves M.J. Do vasomotor nerves significantly regulate cerebral blood flow? Circulation Research. 43:1978;485-495.
233. Raichle, M.E., Hartman, B.K., Eichling, J.O., Sharpe, L.G., 1975. Central noradrenergic regulation of cerebral blood flow and vascular permeability. In: Proceedings of the National Academy of Sciences, USA, 72, pp. 3726-3730.
234. Reinscheid R.K., Nothacker H-P., Bourson A. Orphanin FQ: a neuropeptide that activates an opioid-like G protein-coupled receptor. Science. 270:1995;792-794.
235. Reinhard J.F. Jr, Liebmann J.E., Schlossberg A.J., Moskowitz M.A. Serotonine neurons project to small blood vessels in the brain. Science. 206:1979;85-87.
236. Reis D.J. Nervous control of the cerebral blood flow in normal health and in relationship to cerebrovascular disease. Castaigne P., Lhermitte F., Gautier J.C., Moriniére A. Maladies Vasculaires Cérebrales: Deuxiéme Conférence de la Salpetriére. 1979;197-224 Bailliére-Tindall, Paris.
237. Reis D.J., Iadecola C. Regulation by the brain of its blood flow and metabolism: Role of intrinsic neuronal networks and circulating catecholamines. Owman C., Hardebo J.E. Neural Regulation of Brain Circulation. 1986;129-145 Elsevier, Amsterdam.
238. Reis D.J., Berger S.B., Underwood M.D., Khayata M. Electrical stimulation of cerebellar fastigial nucleus reduces ischemic infarction elicited by middle cerebral artery occlusion in rat. Journal of Cerebral Blood Flow and Metabolism. 11:1991;810-818.
239. Reis D.J., Golanov E.V., Ruggiero D.A., Sun M.K. Sympatho-excitatory neurons of the rostral ventrolateral medulla are oxygen sensors and essential elements in the tonic and reflex control of the systemic and cerebral circulations. Journal of Hypertension. 12:(10):1994;S159-S180.
240. Rennels M.G., Forbes M.S., Anders J.J., Nelson E. Innervation of the microcirculation in the central nervous system and other tissue. Owman C., Edvinson L. Neurogenic Control of the Brain Circulation. 1977;91-104 Pergamon Press, Oxford.
241. Rosenblum W.I. Some physiologic properties of nerves in the adventitia of cerebral blood vessels as revealed by fluorescence microscopy. Cervós-Navarro J., Betz E., Matakas F., Wullenweber R. The Cerebral Vessel Wall. 1976;183-189 Raven Press, New York.
242. Rosenblum W.I. The 'richness' of sympathetic innervaton. A comparison of cerebral blood vessels. Stroke. 7:1976;270-271.
243. Roy C.S., Sherrington C.S. On the regulation of the blood supply of the brain. Journal of Physiology. 11:1890;85-108.
244. Sadoshima S., Busija D.W., Brody M.J., Heistad D.D. Sympathetic nerves protect againist stroke in stroke-prone hypertensive rats. A preliminary study. Hypertension. 3:1981;1124-1127.
245. Sadoshima S., Busija D.W., Heistad D.D. Mechanisms of protection againt stroke in stroke-prone spontaneously hypertensive rats. American Journal of Physiology. 244:1983;H406-H412.
246. Saeki Y., Sato A., Sato Y., Trzebski A. Stimulation of rostral ventrolateral medullary neurons increases cortical cerebral blood flow via activation of the intracerebral neuronal pathway. Neuroscience Letters. 107:1989;26-32.
247. Saffrey M.J., Burnstock G. Growth factors and the development and plasticity of the enteric nervous system. Journal of the Autonomic Nervous System. 49:1994;183-196.
248. Saito A., Wu J-Y., Lee T.J-F. Evidence for the presence of cholinergic nerves in cerebral arteries: An immunohistochemical demonstration of choline acethyltransferase. Journal of Cerebral Blood Flow and Metabolism. 5:1985;327-334.
249. Saito A., Lee T.J-F. Serotonin as an alternative transmitter in sympathetic nerves of large cerebral arteries of the rabbit. Circulation Research. 60:1987;220-228.
250. Sakakibara Y., Fujiwara M., Muramatsu I. Pharmacological characterization of the α adrenoreceptors of the dog basilar artery. Naunyn-Schmiedeberg's Archives of Pharmacology. 319:1982;1-7.
251. Salter M., Strijbos P.J.L.M., Neale S., Duffy C., Follenfant R.L., Garthwaite J. The nitric oxide-cyclic GMP pathway is required for nociceptive signalling at specific loci within the somatosensory pathway. Neuroscience. 73:(3):1996;649-655.
252. Samarasinghe D.D. The innervation of the cerebral arteries in the rat: An electron microscope study. Journal of Anatomy. 99:1965;815-825.
253. Sándor P., Demchenko I.T., Kovach A.G.B., Moskalenko Y.E. Hypothalamic and thalamic blood flow during somatic afferent stimulation in dogs. American Journal of Physiology. 231:1976;270-275.
254. 2-responsiveness, and brain metabolism in the baboon. Stroke. 8:1977;432-436.
255. 2 changes following local met-enkephalin administration in awake, freely moving cats. Acta Physiol. Hung. 61:1983;155-161.
256. Sándor P., De Jong W., De Wied D. Endorphinergic mechanisms in cerebral blood flow autoregulation. Brain Research. 386:1986;122-129.
257. Sándor P., Cox-van Put J., De Jong W., De Wied D. Continuous measurement of cerebral blood volume in rats with the photoelectric technique: effect of morphine and naloxone. Life Sciences. 39:1986;1657-1665.
258. 5)-enkephalinamide and naloxone on cortical blood flow and cerebral blood volume in experimental brain ischemia in anesthetized cats. Journal of Cerebral Blood Flow and Metabolism. 6:1986;533-588.
259. Sándor P., De Jong W., Wiegant V., De Wied D. Central opioid mechanisms and cardiovascular control in hemorrhagic hypotension. American Journal of Physiology. 253:1987;H507-H511.
260. Sándor P., De Jong W., Barna I., Wiegant V., De Wied D. Disturbed hypothalamic blood flow autoregulation in the rat following hypophysectomy: a role of pituitary β-endorphin? Brain Research. 512:1990;102-106.
261. 2-sensitivity of the cerebral and spinal cord vessels following general opiate receptor blockade by naloxone. Journal of Endocrinological Investigations. 14:(4):1991;231.
262. 2-responsiveness of the cerebral and spinal cord vessels of the cat. Journal of Cerebral Blood Flow and Metabolism. 14:1994;49-58.
263. 2-responsiveness. The FASEB Journal. 9:1995;A348. (abstract).
264. Sato S. An electron microscopic study on the innervation of the intracranial artery of the rat. American Journal of Anatomy. 118:1966;873-890.
265. Schlicker, E., Fink, K., Kathmann, M., Molderings, G.J., Gothert, M. 1997 Effects of imidazolines on noradrenaline release in brain: an investigation into their relationship to imidazoline, alpha 2 and H3 receptors. 30(1), 73-83.
266. Sercombe R., Lacombe P., Aubineau P., Mamo H., Pinard E., Reynier-Rebuffel A.M. Is there an active mechanism limiting the influence of the sympathetic system on the cerebral vascular bed? Evidence for vascular escape from sympathetic stimulation in the rabbit. Brain Research. 164:1979;84-102.
267. Skarby T., Andersson K-E., Edvinsson L. Characterization of the post-synaptic α-adrenoreceptor in isolated feline cerebral arteries. Acta Physiologica Scandinavica. 112:1981;105-107.
268. Skarby T., Andersson K-E. Contraction-mediating α-adrenoreceptors in isolated human omental, temporal and pial arteries. Journal of Anatomic Pharmacology. 4:1984;419-429.
269. Spector S., Baird-Lambert J., Lai F.M. Disposition of norepinephrine in isolated brain microvessels. Owman C., Edvinsson L. Neurogenic Control of the Brain Circulation. 1977;115-120 Pergamon Press, Oxford.
270. Stone E.A., Ariano M.A. Are glial cells targets of the central noradrenergic system? A review of the evidence. Brain Research Review. 14:1989;297-309.
271. Suzuki N., Hardebo J.E., Owman C. Origins and pathways of cerebrovascular vasoactive intestinal polypeptide-positive nerves in rats. Journal of Cerebral Blood Flow and Metabolism. 8:1988;697-712.
272. Suzuki N., Hardebo J.E., Owman C. Origins and pathways of choline acetyltransferase-positive parasympathetic nerve fibers to cerebral vessels in rats. Journal of Cerebral Blood Flow and Metabolism. 10:1990;399-408.
273. Suzuki N., Hardebo J.E., Kahrstrom J., Owman C. Neuropeptide Y coexists with vasoactive intestinal polypeptide in papsympathetic cerebrovascular nerves originating in the sphenopalatine, otic and internal carotid ganglia of the rat. Neuroscience. 36:1990;507-519.
274. Thore C.R., Nam M., Busija D. Phorbol ester-induced prostaglandin production in piglet cortical astroglia. American Journal of Physiology. 267:1994;R34-R37.
275. Toda N. Influence of dopamine and noradrenaline on isolated cerebral arteries of the dog. British Journal of Pharmacology. 58:1976;121-126.
276. Toda N. α-adrenergic receptor subtypes in human, monkey, and dog cerebral arteries. Journal of Pharmacology and Experimental Therapeutics. 226:1983;861-868.
277. Toda N., Ayajiki K., Okamura T. Cerebroarterial relaxation mediated by nitric oxide derived from endothelium and vasodilator nerve. Journal of Vascular Research. 30:1993;61-67.
278. Toda N., Ayajiki K., Yoshida K., Kimura H., Okamura T. Impairment by damage of the phterigopalatine ganglion of nitroxidergic vasodilator nerve function in canine cerebral and retinal arteries. Circulation Research. 72:1993;206-213.
279. Tsubukawa T., Karayama Y., Kondo T., Ueno Y., Hayashi N., Moriyashi N. Changes in local cerebral blood flow and neuronal activity during sensory stimulation in normal and sympathetomized cats. Brain Research. 190:1980;51-65.
280. Tsukahara T., Taniguchi T., Fujiwara M., Handa H. Characterization of α-adrenoreceptors in pial arteries of the bovine brain. Naunyn-Schmiedeberg's Archives of Pharmacology. 324:1993;88-93.
281. Uddman R., Edvinsson L., Owman C., Sundler F. Nerve fibres containing gastrin releasing peptide around pial vessels. Journal of Cerebral Blood Flow and Metabolism. 3:1983;386-390.
282. Underwood M.D., Iadecola C., Sved H.F., Reis D.J. Stimulation of Cl area neurons globally increases regional cerebral blood flow but not metabolism. Journal of Cerebral Blood Flow and Metabolism. 12:1992;844-855.
283. Underwood M.D., Bakalian M.J., Arango V., Smith R.W., Mann J.J. Regulation of cortical blood flow by the dorsal raphé nucleus: Topographical organization of cerebrovascular regulatory regions. Journal of Cerebral Blood Flow and Metabolism. 12:1992;664-673.
284. 3H)-5-Hydroxytryptamine in saphenous vein and cerebral arteries of the dog. Journal of Pharmacology and Experimental Therapeutics. 226:1983;579-588.
285. Vizi E.S. Presynaptic modulation of neurochemical transmission. Progress in Neurobiology. 12:1979;181-290.
286. Vizi E.S. Non-synaptic modulation of transmitter release: pharmacological implication. Trends in Pharmacological Sciences. 2:1980;172-175.
287. Vizi E.S. Non-synaptic Interactions Between Neurons: Modulation of Neurochemical Transmission. Pharmacological and Clinical Aspects. 1984;John Wiley and Sons, Chicester, New York.
288. Vizi E.S., Kiss J., Elenkov I.J. Presynaptic modulation of cholinergic and noradrenergic neurotransmission: interaction between them. News in Physiological Sciences. 6:1991;119-123.
289. Vizi E.S., Lábos E. Non-synapic interactions at presynaptic level. Progress in Neurobiology. 37:1991;145-163.
290. Vizi E.S., Kiss J. Neurochemistry and pharmacology of the major hippocampal transmitter systems: synaptic and nonsynaptic interactions. Hippocampus. 8:1998;566-607.
291. Wagerle L.C., Hefferman T.M., Sacks L.M., Delivoria-Papadopuolos M. Sympathetic effect on cerebral blood flow regulaton in hypoxic newborn lambs. American Journal of Physiology. 245:1983;H487-H494.
292. Wagerle L.C., Kumar S.P., Delivoria-Papadopuolos M. Effects of sympathetic nerve stimulation on cerebral blood flow in newborn pigs. Pediatric Research. 20:1986;131-135.
293. Wagerle L.C., Kurt C.D., Roth R.A. Sympathetic reactivity of cerebral arteries in developing fetal lamb and adult sheep. American Journal of Physiology. 27:1990;H1432-H1438.
294. Wahl M., Kuschinsky W., Bosse O., Olesen J., Lassen N.A., Ingvar D.H., Michaelis J., et al. Effect of l-norepinephrine on the diameter of pial arteries and arterioles in the cat. Circulation Research. 31:1972;248-256.
295. Wahl M., Schilling L., Parsons A., Kaumann A. Involvement of calcitonin gene-related peptide (CGRP) and nitric oxide (NO) in the pial artery dilation elicited by cortical spreading depression. Brain Research. 637:1994;204-210.
296. Waldemar G., Paulson O.B., Barry D.I., Knudsen G.M. Angiotensin converting enzyme inhibition and the upper limit of cerebral blood flow autoregulation: effect of sympathetic stimulation. Circulation Research. 64:1989;1197-1204.
297. Walters B.B., Gillespie S.A., Moskowitz M.A. Cerebrovascular projections from the sphenopalatine and otic ganglia to the middle cerebral artery of the cat. Stroke. 17:1986;488-494.
298. Wang Q., Paulson O.B., Lassen N.A. Effect of nitric oxide blockade by NG-nitro-L-arginine on cerebral blood flow response to changes in carbon dioxide tension. Journal of Cerebral Blood Flow and Metabolism. 12:1992;947-953.
299. Wei E.P., Raper R.J., Kontos H.A., Patterson J.L. Jr. Determinants of response of pial arteries to noradrenaline and sympathetic nerve stimulation. Stroke. 6:1975;654-658.
300. Wei E.P., Kontos H.A., Said S.I. Mechanism of action of vasoactive intestinal polypeptide on cerebral arteries. American Journal of Physiology. 239:1980;H765-H768.
301. Wei E.P., Moskowitz M.A., Boccalini I., Kontos H.A. Calcitonin gene-related peptide mediates nitroglycerin and sodium nitroprusside-induced vasodilation in feline cerebral arterioles. Circulation Research. 70:1992;1313-1319.
302. Willis, T. 1664 Cerebri anatome, cui accessit nervorum, descriptio et usus. Flesher J., London.
303. Yaksh T.L., Wang J-Y., Go V.L.W., Harty G.J. Cortical vasodilatation produced by vasoactive intestinal polypeptide (VIP) and pysiological stimuli in the cat. Journal of Cerebral Blood Flow and Metabolism. 7:1987;315-326.