Subchronic oral toxicity studies with γ-cyclodextrin in rats

Regulatory Toxicology and Pharmacology

Volumn 27, Issue 2, 1998, Pages 178-188

  Lina, B A R ^a   Bar A ^b  

^a TNO   (Netherlands)

^b Bioresco AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA CYCLODEXTRIN; LACTOSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DRUG SAFETY; DRUG TOXICITY; FEMALE; FLUID INTAKE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; ORGAN WEIGHT; PRIORITY JOURNAL; RAT;

ANIMALIA; RATTUS NORVEGICUS; RODENTIA;

EID: 0344588767     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1998.1223     Document Type: Article

References (31)

1. Allegre M., Deratani A. Cyclodextrin uses: From concept to industrial reality. Agro Food Ind. Hi-Technol. 5:1994;9-17.
2. Annison G., Topping D. L. Nutritional role of resistant starch: Chemical structure vs physiological function. Annu. Rev. Nutr. 14:1994;297-320.
3. Bär A. Safety assessment of polyol sweeteners - Some aspects of toxicity. Food Chem. 16:1985;231-241.
4. Bär A. Sugars and adrenomedullary proliferative lesions: The effects of lactose and various polyalcohols. J. Am. Coll. Toxicol. 7:1988;71-81.
5. Bar R., Ulitzur S. Bacterial toxicity of cyclodextrins: LuminousE. coli. Appl. Microbiol. Biotechnol. 41:1994;574-577.
6. Bellringer. β-Cyclodextrin: 52-week toxicity study in the rat and dog. Food Chem. Toxicol. 33:1995;367-376.
7. Dahlqvist A., Thompson D. L. The digestion and absorption of lactose by the intact rat. Acta Physiol. Scand. 61:1964;20-33.
8. 14. Regul. Toxicol. Pharmacol. 27:1998.
9. Donaubauer H. H., Fuchs H., Bär A. Subchronic intravenous toxicity studies with γ-cyclodextrin in rats. Regul. Toxicol. Pharmacol. 27:1998.
10. Frank D. W., Gray J. E., Weaver R. N. Cyclodextrin nephrosis in the rat. Am. J. Pathol. 35:1976;367-382.
11. Fukuda K., Teramoto Y., Goto M., Sakamoto J., Mitsuiki S., Hayashida S. Specific inhibition by cyclodextrins of raw starch digestion by fungal glucoamylase. Biosci. Biotechnol. Biochem. 56:1992;556-559.
12. Irie T., Otagiri M., Sunada M., Uekama K., Ohtani Y., Yamada Y., Sugiyama Y. Cyclodextrin-induced hemolysis and shape changes of human erythrocytesin vitro. J. Pharm. Dyn. 5:1982;741-744.
13. Kondo H., Nakatani H., Hiromi K. In-vitro action of human and porcine α-amylases on cyclomalto-oligosaccharides. Carbohydr. Res. 204:1990;207-213.
14. Le Bas G., Rysanek N. Structural aspects of cyclodextrins. Cyclodextrins and Their Industrial Uses. 1987;Editions Santé Paris. p. 105-130.
15. Leroy-Lechat F., Skiba M., Wouessidjewe D., Duchêne D. Cytotoxicity of cyclodextrins and derivatives. Hedges A. R. Minutes 6th International Symposium on Cyclodextrins. 1992;292-297 Editions Santé Paris.
16. Marshall J. J., Miwa I. Kinetic difference between hydrolyses of γ-cyclodextrin by human salivary and pancreatic alpha-amylases. Biochim. Biophys. Acta. 661:1981;142-147.
17. Matsuda K., Mera Y., Segawa Y., Uchida I., Yokomine A., Takagi K. Acute toxicity study of γ-cyclodextrin (γ-CD) in mice and rats. Oyo Yakuri. 26:1983;287-291.
18. Mora S., Simon I., Elodi P. Studies on the active center of pancreatic amylase. I. Binding of β-cyclodextrin. Mol. Cell. Biochem. 4:1974;205-209.
19. Newberne P. M., Conner M. W., Estes P. The influence of food additives and related materials on lower bowel structure and function. Toxicol. Pathol. 16:1988;184-197.
20. Ohtani Y., Irie T., Uekama K., Fukunaga K., Pitha J. Differential effects of alpha-, beta- and gamma-cyclodextrins on human erythrocytes. Eur. J. Biochem. 186:1989;17-22.
21. Rendleman J. A. Enhanced production of γ-cyclodextrin from corn syrup solids by means of cyclododecanone as selective complexant. Carbohydr. Res. 247:1993;223-237.
22. Roe F. J. C. Relevance for man of the effects of lactose, polyols and other carbohydrates on calcium metabolism seen in rats. Hum. Toxicol. 8:1989;87-98.
23. Schmid G. Cyclodextrin glycosyltransferase production: Yield enhancement by overexpression of cloned genes. TIBTECH. 7:1989;244-248.
24. Schmid G. Preparation and industrial production of cyclodextrin. Comprehensive Supramolecular Chemistry. 1996;Pergamon, Oxford. p. 41-56.
25. Schmid G. Preparation and application of γ-cyclodextrin. Duchêne D. New Trends in Cyclodextrins and Derivatives. 1991;27-54 Editions Santé Paris.
26. SFC, 1996, Minutes of the 105th meeting of the Scientific Committee for Food, III/5156/97.
27. Szejtli J. Cyclodextrins in foods, cosmetics and toiletries. Szeitly J. Proceeding of the First International Symposium on Cyclodextrin. 1982;469-480 Akadémiai Kiadó Budapest.
28. Toyoda K., Hayashi S., Uneyama C., Kawanishi T., Takada K., Takahashi M. Hepatic lesions in F344 rats treated orally with β-cyclodextrin for 13 weeks. Bull. Natl. Inst. Health Sci. (Tokyo). 113:1995;36-43.
29. Environ. Health Criteria. 70:1987;39-59.
30. WHO Food Additive. 1993;173-193.
31. WHO Food Additive Series 35. 1996;257-268.