Disposition of 4-methylbenzoylglycine in rat isolated perfused kidney and effects of hippurates on renal mitochondrial metabolism

Journal of Pharmacy and Pharmacology

Volumn 50, Issue 12, 1998, Pages 1397-1404

  Masereeuw, Rosalinde ^a   Moons, Miek M ^b   Russel, Frans G M ^b  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYLHIPPURIC ACID; BOVINE SERUM ALBUMIN; HIPPURIC ACID; OXYGEN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CALCULATION; CONTROLLED STUDY; DATA ANALYSIS; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DISPOSITION; ISOLATED KIDNEY; KIDNEY FUNCTION; KIDNEY METABOLISM; KIDNEY PERFUSION; KIDNEY TUBULE EXCRETION; MICHAELIS MENTEN KINETICS; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXYGEN CONSUMPTION; RAT;

EID: 0344573008     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1998.tb03366.x     Document Type: Article

References (18)

1. Chasis, H., Redish, J., Goldring, W., Ranges, H. A., Smith, H. W. (1945) The use of sodium p-aminohippurate for the functional evaluation of the human kidney. J. Clin. Invest. 24: 583-588
2. Cox, P. G. F., Moons, M. M., Russel, F. G. M., van Ginneken, C. A. M. (1989) Renal handling of salicyluric acid in the isolated perfused rat kidney: evidence for accumulation in tubular cells. J. Pharmacol. Exp. Ther. 251: 750-755
3. Cox, P. G. F., Moons, M. M., Slegers, J. F. G., Russel, F. G. M., van Ginneken, C. A. M. (1990) Isolated perfused rat kidney as a tool in the investigation of renal handling and effects of nonsteroidal antiinflammatory drugs. J. Pharmacol. Methods 24: 89-103
4. Cox, P. G. F., Moons, M. M., Russel, F. G. M., van Ginneken, C. A. M. (1991) Renal handling and effects of salicylic acid in the isolated perfused rat kidney. Pharmacol. Toxicol. 68: 322-328
5. Forster, R. P., Copenhaver Jr, J. H. (1956) Intracellular accumulation as an active process in a mammalian renal transport system in vitro. Energy dependence and competitive phenomena. Am. J. Physiol. 186: 167-171
6. Grantham, J. J., Chonko, A. M. (1991) Renal handling of organic anions and cations: excretion of uric acid. In: Brenner, B. M., Rector Jr, F. C. (eds) The kidney. W. B. Saunders, Philadelphia, pp 483-509
7. Heyrovski, A. (1956) A new method for the determination of inulin in plasma and urine. Clin. Chim. Acta 1: 470-474
8. Kirsch, R., Fleischner, G., Kamisaka, K., Arias, I. M. (1975) Structural and functional studies of ligandin, a major renal organic anion-binding protein. J. Clin. Invest. 55: 1009-1019
9. Masereeuw, R., van den Bergh, E. J., Bindels, R. J. M., Russel, F. G. M. (1994) Characterization of fluorescein transport in isolated proximal tubular cells of the rat: evidence for mitochondrial accumulation. J. Pharmacol. Exp. Ther. 269: 1261-1267
10. Masereeuw, R., Moons, M. M., Russel, F. G. M. (1996a) Renal excretion and accumulation kinetics of 2-methylbenzoylglycine in the isolated perfused rat kidney. J. Pharm. Pharmacol. 48: 560-565
11. Masereeuw, R., Saleming, W. C., Miller, D. S., Russel, F. G. M. (1996b) Interaction of fluorescein with the dicarboxylate carrier in rat kidney cortex mitochondria. J. Pharmacol. Exp. Ther. 279: 1559-1565
12. Metzler, C. M., Weiner, D. L. (1986) Statistical Consultants, Inc. PCNONLIN and NONLIN84: software for the statistical analysis of nonlinear models. Am. Statist. 40: 52
13. Pritchard, J. B., Miller, D. S. (1996) Renal secretion of organic anions and cations. Kidney Int. 49: 1649-1654
14. Russel, F. G. M., Wouterse, A. C., Hekman, P., Grutters, G. J., van Ginneken, C. A. M. (1987) Quantitative urine collection in renal clearance studies in the dog. J. Pharmacol. Methods 17: 125-136
15. Russel, F. G. M., Wouterse, A. C., van Ginneken, C. A. M. (1989a) Renal clearance of substituted hippurates in the dog. I. Benzoylglycine (hippurate) and methyl-substituted benzoylglycines. J. Pharmacol. Exp. Ther. 248: 428-435
16. Russel, F. G. M., Wouterse, A. C., van Ginneken, C. A. M. (1989b) Renal clearance of substituted hippurates in the dog. II. 4-Amino-, hydroxy-and methoxy-substituted benzoylglycines. J. Pharmacol. Exp. Ther. 248: 436-446
17. Schäli, C., Roch-Ramel, F. (1981) Uptake of [3H]PAH and [14C]urate into isolated proximal segments of the pig kidney. Am. J. Physiol. 241: F591-F596
18. Tune, B. M., Burg, M. B., Patlak, C. S. (1969) Characteristics of p-aminohippurate transport in proximal renal tubules. Am. J. Physiol. 217: 1057-1063