Iron deficiency anemia and restless legs syndrome: Is there an electrophysiological abnormality?

Clinical Neurology and Neurosurgery

Volumn 106, Issue 1, 2003, Pages 23-27

  Akyol, Ali ^a   Kiylioglu, Nefati ^a   Kadikoylu, Gurhan ^a   Bolaman, Ali Zahit ^a   Ozgel, Nihat ^a  

^a ADNAN MENDERES UNIVERSITY   (Turkey)

Author keywords

Anemia; Electrophysiologic study; EMG; Iron deficiency; Restless legs syndrome

Indexed keywords

ADULT; AGED; ARTICLE; BLINKING; BRAIN FUNCTION; BRAIN STEM; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROMYOGRAPHY; ELECTROPHYSIOLOGY; EYELID REFLEX; FEMALE; HOFFMANN REFLEX; HUMAN; INNERVATION; IRON DEFICIENCY ANEMIA; LATENT PERIOD; LEG; MALE; MOTONEURON; MOTOR NERVE CONDUCTION; NEUROLOGIC EXAMINATION; NEUROPHYSIOLOGY; PATHOPHYSIOLOGY; PERIPHERAL NERVE; PERIPHERAL NERVOUS SYSTEM; PHYSIOLOGY; REACTION TIME; REFERENCE VALUE; RESTLESS LEGS SYNDROME; SENSORY NERVE CELL; SENSORY NERVE CONDUCTION; SKELETAL MUSCLE; SPINAL CORD; SYNAPTIC TRANSMISSION;

EID: 0344551890     PISSN: 03038467     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clineuro.2003.07.004     Document Type: Article

References (29)

1. Ekbom K.A. Restless legs syndrome. Neurology. 10:1960;868-873.
2. Rothdach A.J., Trenkwalder C., Haberstock J., Keil U., Berger K. Prevalence and risk factors of RLS in an elderly population. The MEMO study. Neurology. 54:2000;1064-1068.
3. O'Keeffe S.T. Restless legs syndrome. Arch. Intern. Med. 156:1996;243-247.
4. Ondo W., Jankovic J. Restless legs syndrome: clinicoetiologic correlates. Neurology. 47:1996;1435-1441.
5. Briellmann R.S., Rösler K.M., Hess C.W. Blink reflex excitability is abnormal in patients with periodic leg movements in sleep. Mov. Disord. 11:1996;710-714.
6. Polydefkis M., Allen R.P., Hauer P., Early C.J., Griffin J.W., McArtur J.C. Subclinical sensory neuropathy in late-onset restless legs syndrome. Neurology. 55:2000;1115-1121.
7. Iannacone S., Ferrini-Strambi L., Zucconi M.et al. Peripheral nerve investigation in restless legs syndrome. J. Neurol. 241(Suppl 1):1994;S156.
8. Ekbom KA. Restless legs. In: Vinken PJ, Bruyn GW, editors. Handbook of clinical neurology. Amsterdam: North-Holland; 1970. p. 311-20.
9. Montplaisir J., Godbout R., Boghen D.et al. Familial restless legs with periodic movements in sleep: electrophysiological biochemical and pharmacological study. Neurology. 35:1985;130-134.
10. Frankel B.L., Patten B.M., Gillin J.C. Restless legs syndrome: sleep-electroencephalographic and neurologic findings. JAMA. 230:1974;1302-1303.
11. Harriman D.G.F., Taverner D., Woolf A.L. Ekbom's syndrome and burning parasthesiae: a biopsy study by vital staining and electron microscopy of the intramuscular innervation with a note on age changes in motor nerve endings in distal muscles. Brain. 93:1970;393-406.
12. Deuschl G, Eisen A (editors). Recommendatios for the practise of clinical neurophysiology: guidelines of the international federation of clinical neurophysiology. Electroenceph Clin Neurophysiol (Suppl 52) 2nd Revised and Enlarged Edition. The Netherlands: Elsevier; 1999. p. 1-304.
13. Kabakus N., Ayar A., Yoldas T.K.et al. Reversal of iron deficiency anemia-induced peripheral neuropathy by iron treatment in children with iron deficiency anemia. J. Trop. Pediatr. 48:2002;204-209.
14. Mosko S.S., Nudleman K.L. Somatosensory and brainstem auditory evoked responses in sleep-related periodic leg movements. Sleep. 9:1986;339-404.
15. Bucher S.F., Trenkwalder C., Oertel W.H. Reflex studies and MRI in the restless legs syndrome. Acta Neurol. Scand. 94:1996;145-150.
16. Trenkwalder C., Walters A.S., Hening W. Periodic limb movements and restless legs syndrome. Neurol. Clin. 14:1996;629-650.
17. Salvi F., Montagna P., Plasmati R.et al. Restless leg syndrome and nocturnal myoclonus: initial clinical manifestation of familial amyloid polyneuropathy. J. Neurol. Neurosurg. Psychiatry. 53:1990;522-525.
18. Lugaresi E, Coccagna G, Ceroni GB, Ambrosetto C. Restless legs syndrome and nocturnal myoclonus. In: Gastaut H, editor. The abnormalities of sleep in man. Bologna, Italy: Aulo Gaggi Editore; 1968. p. 285-94.
19. Gemingnani F., Marbini A. Restless legs syndrome and peripheral neuropathy. J. Neurol. Neurosurg. Psychiatry. 72:2002;555.
20. Calabresi P.A., Silvestri G., DiMauro S., Griggs R.C. Ekbom's syndrome: lipomas, ataxia, and neuropathy with MERRF. Muscle Nerve. 17:1994;943-945.
21. Entezari-Taher M., Singleton J.R., Jones C.R.et al. Changes in excitability of motor cortical circuitry in primary restless legs syndrome. Neurology. 53:1999;1201-1205.
22. Tergau F., Wischer S., Paulus W. Motor system excitability in patients with restless legs syndrome. Neurology. 52:1999;1060-1063.
23. Bara-Jimenez W., Aksu M., Sato G.S.et al. Periodic limb movements in sleep. State dependent excitability of the spinal flexor reflex. Neurology. 54:2000;1609-1615.
24. Schomburg E.D., SteVens H. Analysis of L-DOPA actions on nociceptive and non-nociceptive spinal reflex pathways in the cat. Neurosci. Res. 31:1998;307-316.
25. Stiasny K., Wetter T.C., Trenkwalder C., Oertel W.H. Restless legs syndrome and its treatment by dopamine agonists. Parkinsonism Relat. Disord. 7:2001;21-25.
26. Youdim MBH, Yehuda S, Ben Shacker D, Askenazi R. Behavioral and brain biochemical changes in iron deficient rats: the involvement of iron in dopamine receptor function. In: Pollit E, Leibel RL, editors. Iron deficiency: brain biochemistry and behaviour. New York: Raven Press; 1982. p. 39-56.
27. Pall H.S., Williams A.C., Fonseca A., Blake D.R. Restless legs syndrome. Neurology. 37:1987;1436.
28. Early C.J., Connor J.R., Beard J.L., Malecki E.A., Epstein D.K., Allen R.P. Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology. 54:2000;1698-1700.
29. Sun E.R., Chen C.A., Ho G., Earley C.J., Allen R.P. Iron and the restless legs syndrome. Sleep. 21:1998;371-377.