Effects of Food on the Bioavailability of Gepirone from Extended-Release Tablets in Humans: Results of Two Open-Label Crossover Studies

Current Therapeutic Research - Clinical and Experimental

Volumn 64, Issue 8, 2003, Pages 580-598

  Fabre, Louis F ^a,c   Timmer, Cees J ^b  

^a Fabre Research Clinic Inc   (United States)

^b Dept of Drug Metab and Kinetics ^*  (Netherlands)

^c Fahre Research Clinic Inc   (United States)

Author keywords

5 ht1a agonist; Anxiety; Bioavailability; Depression; Gepirone

Indexed keywords

1 (2 PYRIMIDINYL)PIPERAZINE; ANTIDEPRESSANT AGENT; GEPIRONE; SEROTONIN 1 AGONIST; SEROTONIN 1A RECEPTOR;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEPRESSION; DIET RESTRICTION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG SAFETY; DRUG TOLERABILITY; FOOD INTAKE; HUMAN; LIPID DIET; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TABLET;

EID: 0344514766     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.curtheres.2003.09.012     Document Type: Article

References (16)

1. Hamik A, Oksenberg D, Fischette C, Peroutka SJ. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol Psychiatry. 1990;28: 99-109.
2. 1A agonists in the treatment of depres-sion? Biol Psychiatry. 2003;53:193-203.
3. Andrade R, Nicoll RA. Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus. Naunyn Schmiedebergs Arch Pharmacol. 1987;336:5-10.
4. 1A agonist gepirone: Electrophysiological studies in the rat brain. Synapse. 1987;1:470-480.
5. Eison AS. Azapirones: History of development. J Clin Psychopharmacol. 1990;10(Suppl 3):2S-5S.
6. Jenkins SW, Robinson DS, Fabre LF Jr, et al. Gepirone in the treatment of major depression. J Clin Psychopharmacol. 1990;10(Suppl 3):77S-85S.
7. McGrath PJ, Stewart JW, Quitkin FM, et al. Gepirone treatment of atypical depression: Preliminary evidence of serotonergic involvement. J Clin Psychopharmacol. 1994;14: 347-352.
8. Feiger AD, Heiser JF, Shrivastava RK, et al. Gepirone extended-release: New evidence for efficacy in the treatment of major depressive disorder. J Clin Psychiatry. 2003; 64:243-249.
9. Feiger AD. A double-blind comparison of gepirone extended release, imipramine, and placebo in the treatment of outpatient major depression. Psychopharmacol Bull. 1996;32:659-665.
10. Wilcox CS, Ferguson JM, Dale JL, Heiser JF. A double-blind trial of low-and high-dose ranges of gepirone-ER compared with placebo in the treatment of depressed outpatients. Psychopharmacol Bull. 1996;32:335-342.
11. 14C-gepirone. Pharm Res. 1990;7(Suppl 9):S208. Abstract.
12. Welling PG. Effects of food on drug absorption. Pharmacol Ther. 1989;43:425-441.
13. Olanoff LS, Walle T, Cowart TD, et al. Food effects on propranolol systemic and oral clearance: Support for a blood flow hypothesis. Clin Pharmacol Ther. 1986;40:408-414.
14. Tay LK, Sciacca MA, Sostrin MB, et al. Effect of food on the bioavailability of gepirone in humans. J Clin Pharmacol. 1993;33:631-635.
15. Gibaldi M, Perrier D. Noncompartmental analysis based on statistical moment theory. Pharmacokinetics. 2nd ed. New York, NY: Marcel Dekker; 1982:409-417.
16. Melander A, Lalka D, McLean A. Influence of food on the presystemic metabolism of drugs. Pharmacol Ther. 1988;38:253-267.