25 mg or 50 mg of oral methotrexate followed by vaginal misoprostol 7 days after for early abortion. A randomized trial

Gynecologic and Obstetric Investigation

Volumn 47, Issue 3, 1999, Pages 182-187

  Esteve, Josep Lluis Carbonell ^a,c   Varela, L ^b   Velazco, A ^b   Tanda, R ^b   Sanchez C ^b  

^a Family Planning Center   (Spain)

^b Hosp Docente Gineco Obstetrico E   (Cuba)

^c Mediterranea Medica Clinic   (Spain)

Author keywords

Medical abortion; Methotrexate; Misoprostol

Indexed keywords

METHOTREXATE; MISOPROSTOL;

ABORTION; ADULT; ARTICLE; BLEEDING; CHILL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG SAFETY; FATIGUE; FEMALE; FEVER; HEADACHE; HUMAN; INTRAVAGINAL DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MOUTH ULCER; NAUSEA; ORAL DRUG ADMINISTRATION; OUTCOMES RESEARCH; PELVIS PAIN SYNDROME; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; SIDE EFFECT; SPOTTING; SURGERY; VAGINA BLEEDING; VERTIGO; VOMITING;

EID: 0344507379     PISSN: 03787346     EISSN: None     Source Type: Journal    
DOI: 10.1159/000010090     Document Type: Article

References (21)

1. Slovall TG, Ling FW: Single-dose methotrexate: An expanded clinical trial. Am J Obstet Gynecol 1993;168:1759-1765.
2. Creinin MD: Methotrexate for abortion at <42 days gestation. Contraception 1993;48:519-525.
3. Creinin MD, Vittinghoff E, Galbraith S, Klaisle C: A randomized trial comparing misoprostol 3 and 7 days following methotrexate for early abortion. Am J Obstet Gynecol 1995;173: 1578-1584.
4. Creinin MD, Vittinghoff E, Keder L, Darney PD, Tiller G: Methotrexate and misoprostol for early abortion: A multicenter trial. I. Safety and efficacy. Contraception 1996;53:321-327.
5. Hausknecht RU: Methotrexate and misoprostol to terminate early pregnancy. N Engl J Med 1995;333:537-540.
6. Schaff E, Eisinger SH, Franks P, Kim SS: Combined methotrexate and misoprostol for early induced abortion. Arch Fam Med 1995;4:774-779.
7. Carbonell JLL, Varela L, Velazco A, Cabezas E, Fernández C, Sánchez C: Misoprostol three, four or five days after methotrexate for early abortion: A randomized trial. Contraception 1997;56:169-174.
8. Creinin MD: Oral methotrexate and vaginal misoprostol for early abortion. Contraception 1996;54:15-18.
9. Creinin MD, Vittinghoff E, Schaff E, Klaisle C, Darney PD, Dean C: Medical abortion with methotrexate and vaginal misoprostol. J Obstet Gynecol 1997;56:165-168.
10. Carbonell JLL, Varela L, Velazco A, Cabezas E, Sánchez C: Oral methotrexate and vaginal misoprostol for early abortion. Contraception 1998;57:83-88.
11. Carbonell JLL, Varela L, Velazco A, Fernández C: The use of misoprostol for termination of early pregnancy. Contraception 1997;55:165-168.
12. Carbonell JLL, Varela L, Velazco A, Fernández C, Sánchez C: The use of misoprostol for abortion of ≤9 weeks' gestation. Eur J ontracept Reprod Health Care 1997;2:181-185.
13. Bugalho A, Bique C, Almeida L, Faúndes A: The effectiveness of intravaginal misoprostol (Cytotec) in inducing abortion after eleven weeks of pregnancy. Stud Fam Plann 1993;24/ 5:319-323.
14. Bugalho A, Bique C, Almeida L, Bergstrom S: Pregnancy interruption by vaginal misoprostol. Gynecol Obstet Invest 1993;36:226-229.
15. Halprin KM, Fukui K, Ohkawara A: Blood levels of methotrexate and the treatment of psoriasis. Arch Derm 1971;103:243-249.
16. Henderson ES, Adamson RH, Oliverio VT: The metabolic fate of titrated methotrexate. II. Absorption and excretion in man. Cancer Res 1965;25:1018-1024.
17. Oguey D, Kölliker F, Gerber NJ, Reichen J: Effect of food on the bioavailability of low-dose methotrexate in patients with rheumatoid arthritis. Arthritis Rheum 1992;35:611-614.
18. Shen DD, Azamoff DL: Clinical pharmacokinetics of methotrexate. Clin Pharmacokinet 1978;3:1-13.
19. Goldstein SR, Wolfson R: Endovaginal ultrasonographic measurements of early embryonic size as a means of assessing gestational age. J Ultrasound Med 1994;13:27-31.
20. Donner A: Approaches to sample size estimations in the design of clinical trials. Statist Med 1984;3:199-214.
21. Winikoff B, Ellertson C, Clark S: Analysis of failure in medical abortion. Contraception 1996;54:323-327.