Infusions with molsidomine and isosorbide-5-mononitrate in congestive heart failure: Mechanisms underlying attenuation of effects

Journal of Cardiovascular Pharmacology

Volumn 31, Issue 2, 1998, Pages 212-220

  Lehmann, Günter ^a   Hähnel, Iris ^a   Reiniger, Günther ^a   Lampen, Martin ^a   Beyerle, Andrea ^a   Schömig, Albert ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Heart failure; Hemodynamics; Isosorbide 5 mononitrate; Molsidomine; Neurohormones; Tolerance

Indexed keywords

ANGIOTENSIN; CORRATON; GLYCERYL TRINITRATE; ISOSORBIDE 5 NITRATE; MOLSIDOMINE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG TOLERANCE; FEMALE; FLUID SHIFT; HEART FAILURE; HEART OUTPUT; HEART STROKE VOLUME; HEMATOCRIT; HEMODYNAMIC PARAMETERS; HEMODYNAMICS; HUMAN; INFUSION; INTRAVENOUS DRUG ADMINISTRATION; LUNG ARTERY PRESSURE; MALE; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VASCULAR RESISTANCE;

ADULT; AGED; ALDOSTERONE; BLOOD PRESSURE; DOUBLE-BLIND METHOD; DRUG TOLERANCE; FEMALE; FLUID SHIFTS; HEART ATRIA; HEART FAILURE, CONGESTIVE; HEART RATE; HEMATOCRIT; HEMODYNAMIC PROCESSES; HUMANS; ISOSORBIDE DINITRATE; MALE; MIDDLE AGED; MOLSIDOMINE; NEUROTRANSMITTER AGENTS; PULMONARY ARTERY; RENIN; TIME FACTORS; VASCULAR RESISTANCE; VASODILATOR AGENTS; VENTRICULAR FUNCTION, LEFT;

EID: 0344505805     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199802000-00006     Document Type: Article

References (33)

1. Cohn JN, Archibald DG, Ziesche S, et al. Effect of vasodilator therapy on mortality in chronic congestive heart failure: results of a Veterans Administration Cooperative Study. N Engl J Med 1986; 314:1547-52.
2. Cohn JN, Johnson G, Ziesche S, et al. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med 1991;325:303-10.
3. Kojda G, Kottenberg K, Nix P, Schlüter KD, Piper HM, Noack E. Low increase in cGMP induced organic nitrates and nitrovasodilators improves contractile response or rat ventricular myocytes. Circ Res 1996;78:91-101.
4. Rudolph W, Dirschinger J. Clinical comparison of nitrates and sydnonimines. Eur Heart J 1991;12(suppl E):33-41.
5. Needleman P, Johnson EM. Mechanism of tolerance development to organic nitrates. J Pharmacol Exp Ther 1973;184(3):709-15.
6. Ignarro LJ, Lippton H, Edwards JC, et al. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther 1981;218(3):739-49.
7. Lehmann G, Reiniger G, Haase H-U, Rudolph W. Enhanced effectiveness of sustained-release forms of isosorbide dinitrate and diltiazem for stable angina pectoris. Am J Cardiol 1991;68:983-90.
8. Lehmann G, Reiniger G, Wolf H, Beyerle A, Rudolph W. Anti-ischemic effects of first and second dose of 20 mg isosorbide dinitrate administered 5 hours apart: attenuation of effects despite rising plasma concentrations. Cardiovasc Drugs Ther 1995;9:339-45.
9. Unger P, Vachiery J-L, de Cannière D, Staroukine M, Berkenboom G. Comparison of the hemodynamic responses to molsidomine and isosorbide dinitrate in congestive heart failure. Am Heart J 1994;128: 557-63.
10. Pizzulli L, Hagendorff A, Zirbes M, et al. Influence of captopril on nitroglycerin-mediated vasodilation and development of nitrate tolerance in arterial and venous circulation. Am Heart J 1996;131:342-9.
11. Münzel T, Kurz S, Heitzer T, Harrison DG. New insights into mechanisms underlying nitrate tolerance. Am J Cardiol 1996;77:24-30C.
12. Feelisch M, Ostrowski J, Noack E. On the mechanism of NO-release from sydnonimines. J Cardiovasc Pharmacol 1989;14(suppl 11):13-22.
13. Ostrowski J, Resag K. Pharmacokinetics of molsidomine in humans. Am Heart J 1985;109:641-3.
14. Bassenge E, Zanzinger J. Nitrates in different vascular beds, nitrate tolerance, and interactions with endothelial function. Am J Cardiol 1992;70:23-9B.
15. Lehmann G, Reiniger G, Beyerle A, Zeitler H, Rudolph W. Haemodynamic evaluation of two regimens of molsidomine in patients with chronic congestive heart failure. Eur J Clin Pharmacol 1995;48:109-14.
16. Ibrahim TM, Unger PH, Sobolski J, Depelchin P, Jottrand M, Degré S. Hemodynamic effects of SIN-1 in acute left heart failure. Cardiovasc Drugs Ther 1989;3:557-61.
17. Davidson CJ, Fishman RF, Bonow RO. Cardiac catheterization. In: Braunwald E, ed. Heart disease. Philadelphia: WB Saunders, 1996: 177-203.
18. Mettauer B, Rouleau JL, Bichet D, et al. Differential long-term intrarenal and neurohumoral effects of captopril and prazosin in patients with chronic congestive heart failure: importance of initial plasma renin activity. Circulation 1986;73:492-502.
19. Dupuis J, Lalonde G, Lebeau R, Bichet D, Rouleau JL. Sustained beneficial effect of a seventy-two hour intravenous infusion of nitroglycerin in patients with severe chronic congestive heart failure. Am Heart J 1990;120:625-37.
20. Weicker H. Determination of free and sulfoconjugated catecholamines in plasma and urine by HPLC. Int J Sports Med 1988;9 (suppl):68-74.
21. Wilson N, Ledsome JR, Keeler R, Rankin AJ, Wade JP, Courneya CA. Heterologous radioimmunoassay of atrial natriuretic peptide in dog and rabbit plasma. J Immunoassay 1986;7:73-6.
22. Tsutamoto T, Kanamori T, Wada A, Kinoshita M. Uncoupling of atrial natriuretic peptide extraction and cyclic guanosine monophosphate production in pulmonary circulation in patients with severe heart failure. J Am Coll Cardiol 1992;20:541-6.
23. Chappell MC, Brosnihan KB, Welches WR, Ferrario CM. Characterization by high performance liquid chromatography of angiotensin peptides in the plasma and cerebrospinal fluid of the dog. Peptides 1987;8:939-42.
24. Dell D, Chamberlain J. Determination of molsidomine in plasma by high-performance liquid column chromatography. J Chromatogr 1978;146:465-72.
25. Jaeger H, Lutz D, Michaelis K, Salama ZB. Determination of nitrates in plasma. Drugs 1987;33(suppl 4):9-22.
26. Elkayam U. Nitrates in the treatment of congestive heart failure. Am J Cardiol 1996;77:41-51C.
27. Mohanty N, Wasserman AG, Walker P, Katz RJ. Prevention of nitroglycerin tolerance with diuretics. Am Heart J 1995;130:522-7.
28. Schlack W, Uebing A, Schafer M, et al. Intracoronary SIN-1 C during reperfusion reduces infarct size in dogs. J Cardiovasc Pharmacol 1995;25:424-31.
29. Meinertz T, Brandstätter A, Trenk D, Jähnchen E, Ostrowski J, Gärtner W. Relationship between pharmacokinetics and pharmacodynamics of molsidomine and its metabolites in humans. Am Heart J 1985; 109:644-8.
30. Beyerle A, Lehmann G, Reiniger G, Rudolph W. No loss of action with the nitrate-like substance molsidomine during established nitrate tolerance. J Vasc Med Biol 1994;4(5/6):260-4.
31. Rietbrock S, Keller-Stanislawski B, Thürmann P, Brockmeier D. Pharmacokinetic profile of a novel slow release preparation of molsidomine. Eur J Clin Pharmacol 1992;43:273-6.
32. Cloarec-Blanchard L, Funck-Brentano C, Carayon A, Jaillon P. Rapid development of nitrate tolerance in healthy volunteers: assessment using spectral analysis of short-term blood pressure and heart rate variability. J Cardiovasc Pharmacol 1994;24: 266-73.
33. Parker JD. Counterregulatory responses: sustained-release isosorbide-5-mononitrate versus transdermal nitroglycerin. J Cardiovasc Pharmacol 1996;28:631-8.