Metabolic and thermodynamic responses to dehydration- induced reductions in muscle blood flow in exercising humans

Journal of Physiology

Volumn 520, Issue 2, 1999, Pages 577-589

  González Alonso, José ^a   Calbet, José A L ^b   Nielsen, Bodil ^b  

^a Rigshospitalet   (Denmark)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; FATTY ACID; GLUCOSE; GLYCEROL; LACTIC ACID; CATECHOLAMINE; GLUCAGON; GLYCOGEN; INSULIN;

ADULT; ARTICLE; BICYCLE ERGOMETER; CONTROLLED STUDY; CORE TEMPERATURE; DEHYDRATION; ENERGY CONSUMPTION; ESOPHAGUS; EXERCISE; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; GLYCOGEN MUSCLE LEVEL; HEAT TRANSFER; HUMAN; HUMAN EXPERIMENT; LACTATE BLOOD LEVEL; LEG BLOOD FLOW; MALE; METABOLISM; MUSCLE BLOOD FLOW; MUSCLE FATIGUE; MUSCLE LEVEL; NORMAL HUMAN; OXIDATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; TEMPERATURE; THERMODYNAMICS; THERMOGENESIS; WEIGHT REDUCTION; BODY TEMPERATURE MEASUREMENT; CARBOHYDRATE METABOLISM; EXERCISE INTENSITY; EXHAUSTION; GLYCOGEN METABOLISM; HYPERTHERMIA; LIPID METABOLISM; MUSCLE METABOLISM;

ADULT; BLOOD GLUCOSE; BODY TEMPERATURE; CARBON DIOXIDE; DEHYDRATION; EPINEPHRINE; EXERCISE; EXERCISE TEST; FATIGUE; FATTY ACIDS, NONESTERIFIED; FEVER; GLUCAGON; GLYCEROL; GLYCOGEN; HUMANS; INSULIN; LACTIC ACID; MALE; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PHOSPHOCREATINE; REGIONAL BLOOD FLOW; THERMODYNAMICS;

EID: 0344500694     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1999.00577.x     Document Type: Article

References (43)

1. AHLBORG, G. & FELIG, P. (1977). Substrate utilisation during prolonged exercise preceded by ingestion of glucose. American Journal of Physiology 233, E188-194.
2. AHLBORG, G., FELIG, P., HAGENFELDT, L., HENDLER, R. & WAHREN, J. (1974). Substrate turnover during prolonged exercise in man: splanchnic and leg metabolism of glucose, free fatty acids and amino acids. Journal of Clinical Investigation 53, 1080-1090.
3. ANDERSEN, P. & SALTIN, B. (1985). Maximal perfusion of skeletal muscle in man. Journal of Physiology 366, 233-249.
4. BANGSBO, J., GRAHAM, T., JOHANSEN, L. & SALTIN, B. (1994). Muscle lactate metabolism in recovery from intense exhaustive exercise: impact of light exercise. Journal of Applied Physiology 77, 1890-1895.
5. BERGMAN, B. C., BUTTERFIELD, G. E., WOLFEL, E. E., CASAZZA, G. A., LOPASCHUK, G. D. & BROOKS, G. (1999). Evaluation of exercise and training on muscle lipid metabolism. American Journal of Physiology 276, E106-117.
6. BORG, G. (1975). Simple rating methods for estimation of perceived exertion. In Physical Work and Effort, ed. BORG, G., pp. 39-46. Pergamon Press, New York.
7. BROOKS, G. A., HITTLEMAN, K. J., FAULKNER, J. A. & BEYER, R. A. (1971). Temperature, skeletal muscle mitochondrial functions, and oxygen debt. American Journal of Physiology 220, 1053-1059.
8. CHRISTIANSEN, N. J., VESTERGAARD, P., SØRENSEN, T. & RAFAELSEN, O. J. (1980). Cerebrospinal fluid adrenaline and noradrenaline in depressed patients. Acta Psychiatrica Scandinavica 61, 178-182.
9. COYLE, E. F., JEUKENDRUP, A. E., WAGENMARKERS, A. J. & SARIS, W. (1997). Fatty acid oxidation is directly regulated by carbohydrate metabolism during exercise. American Journal of Physiology 273, E268-275.
10. 2 content. Journal of Applied Physiology 65, 473-477.
11. FEBBRAIO, M. A., CAREY, M. F., SNOW, R. J., STATHIS, C. G. & HARGREAVES, M. (1996). Influence of elevated muscle temperature on metabolism during intense, dynamic exercise. American Journal of Physiology 271, R1251-1255.
12. FEBBRAIO, M. A., LAMBERT, D. L., STARKIE, R. L., PROIETTO, J. & HARGREAVES, M. (1998). Effect of epinephrine on muscle glycogenolysis during exercise in trained men. Journal of Applied Physiology 84, 465-470.
13. GONZÁLEZ-ALONSO, J., CALBET, J. A. L. & NIELSEN, B. (1998). Muscle blood flow is reduced with dehydration during prolonged exercise in humans. Journal of Physiology 513, 895-905.
14. GONZÁLEZ-ALONSO, J., MORA-RODRÍGUEZ, R., BELOW, P. R. & COYLE, E. F. (1995). Dehydration reduces cardiac output and increases systemic and cutaneous vascular resistance during exercise. Journal Applied Physiology 79, 1487-1496.
15. GONZÁLEZ-ALONSO, J., MORA-RODRÍGUEZ, R., BELOW, P. R. & COYLE, E. F. (1997). Dehydration markedly impairs cardiovascular function in hyperthermic endurance athletes during exercise. Journal of Applied Physiology 82, 1229-1236.
16. GONZÁLEZ-ALONSO, J., TELLER, C., ANDERSEN, S. L., JENSEN, F. B., HYLDIG, T. & NIELSEN, B. (1999). Influence of body temperature on the development of fatigue during prolonged exercise in the heat. Journal of Applied Physiology 86, 1032-1039.
17. GRAHAM, T. E., KIENS, B., HARGREAVES, M. & RICHTER, E. (1991). Influence of fatty acids on ammonia acid flux from active human muscle. American Journal of Physiology 261, E168-176.
18. HAMILTON, M. T., GONZÁLEZ-ALONSO J., MONTAIN, S. J. & COYLE, E. F. (1991). Fluid replacement and glucose infusion during exercise prevent cardiovascular drift. Journal of Applied Physiology 71, 871-877.
19. HARGREAVES, M., ANGUS, D., HOWLETT, K., CONUS, N. M. & FEBBRAIO, M. (1996a). Effect of heat stress on glucose kinetics during exercise. Journal of Applied Physiology 81, 1594-1597.
20. HARGREAVES, M., DILLO, P., ANGUS, D. & FEBBRAIO, M. (1996b). Effect of fluid ingestion on muscle metabolism during prolonged exercise. Journal of Applied Physiology 80, 363-366.
21. KIENS, B., ESSEN-GUSTAVSSON, B., CHRISTENSEN, N. J. & SALTIN, B. (1993). Skeletal muscle substrate utilisation during submaximal exercise in man: effect of endurance training. Journal of Physiology 469, 459-478.
22. KJÆER, M., ENGFRED, K., FERNANDES, A., SECHER, N. H. & GALBO, H. (1993). Regulation of glucose production during exercise in humans: role of sympathoadrenergic activity. American Journal of Physiology 265, E275-283.
23. KJÆR, M., KIENS, B., HARGREAVES, M. & RITCHER, E. (1991). Influence of active muscle mass on glucose homeostasis during exercise in humans. Journal of Applied Physiology 71, 552-557.
24. 2 supply and utilisation in man. Journal of Applied Physiology 75, 2586-2594.
25. LOWRY, O. H. & PASSONNEAU, J. V. (1972). A Flexible System of Enzymatic Analysis, pp. 199-201. Academic Press, New York.
26. MONTAIN, S. J. & COYLE, E. F. (1992a). Fluid ingestion during exercise increases skin blood flow independent of increases in blood volume. Journal of Applied Physiology 73, 903-910.
27. MONTAIN, S. J. & COYLE, E. F. (1992b). The influence of graded dehydration on hyperthermia and cardiovascular drift during exercise. Journal of Applied Physiology 73, 1340-1350.
28. MONTAIN, S. J., HOPPER, M. K., COGGAN, A. R. & COYLE, E. F. (1991). Exercise metabolism at different time intervals after a meal. Journal of Applied Physiology 70, 882-888.
29. 31P-MRS study. Journal of Applied Physiology 84, 1889-1894.
30. NADEL, E. R. (1988). Temperature regulation and prolonged exercise. In Perspectives in Exercise Science and Sports Medicine, vol. I, Prolonged Exercise, ed. LAMB, D. R. & MURRA, Y. R., pp. 125-151. Benchmark Press, Indianapolis, Indiana.
31. NIELSEN, B., HALES, J. R. S., STRANGE, S., CHRISTIENSEN, N. J., WARBERG, J. & SALTIN, B. (1993). Human circulatory and thermoregulatory adaptations with heat acclimation and exercise in a hot, dry environment. Journal of Physiology 460, 467-485.
32. NIELSEN, B., KUBICA, R., BONNESEN, A., RASMUSSEN, I. B., STOKLOSA, J. & WILK, B. (1981). Physical work capacity after dehydration and hyperthermia. Scandinavian Journal of Sports Science 3, 2-10.
33. NIELSEN, B., SAVARD, G., RICHTER, E. A., HARGREAVES, M. & SALTIN, B. (1990). Muscle blood flow and metabolism during exercise and heat stress. Journal of Applied Physiology 69, 1040-1046.
34. PÉRONNET, F. & MASSICOTTE, D. (1991). Table of nonprotein respiratory quotient: an update. Canadian Journal of Sports Science 16, 23-29.
35. PITTS, G. C., JOHNSON, R. E. & CONSOLAZIO, F. C. (1944). Work in the heat as affected by intake of water, salt and glucose. American Journal of Physiology 142, 253-259.
36. 2 transport. Journal of Clinical Investigation 96, 1916-1926.
37. ROMIJN, J. A., COYLE, E. F., SIDOSSIS, L. S., GASTALDELLI, A., HOROWITZ, J. F., ENDERT, E. & WOLFE, R. R. (1993). Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. American Journal of Physiology 265, E380-391.
38. SAHLIN, K., TONKONOGI, M. & SÖDERLUND, K. (1998). Energy supply and muscle fatigue in humans. Acta Physiologica Scandinavica 162, 261-266.
39. SALTIN, B. (1964). Aerobic and anaerobic work capacity after dehydration. Journal of Applied Physiology 19, 1114-1118.
40. SALTIN, B., GROVER, R. F., BROMQVIST, C. G., HARTLEY, L. H. & JOHNSON, R. L. (1968). Maximal oxygen uptake and cardiac output after 2 weeks at 4,300 m. Journal of Applied Physiology 25, 400-409.
41. SAWKA, M. N., KNOWLTON, R. G. & CRITZ, J. B. (1979). Thermal and circulatory responses to repeated bouts of prolonged running. Journal of Applied Physiology 19, 833-838.
42. SAWKA, M. N., YOUNG, A. J., LATZKA, W. A., NEUFER, P. D., QUICLEY, M. D. & PANDOLF, K. B. (1992). Human tolerance to heat strain during exercise: influence of hydration. Journal of Applied Physiology 50, 772-778.
43. WILSON, D. L., ERECINSKA, M., DROWN, C. & SILVER, I. A. (1977). Effect of oxygen tension on cellular energetics. American Journal of Physiology 233, C135-140.