Pharmacokinetic study of nerisopam, a novel anxiolytic drug-proband, and its N-acetyl metabolite in rats

Pharmacy and Pharmacology Communications

Volumn 4, Issue 4, 1998, Pages 225-228

  Ary, Kornélia ^a,d   Róna, Kálmán ^a   Renczes, Gábor ^a   Gachályi, Béla ^a   Grézal, Gyula ^c   Klebovich, Imre ^c   Riesz, Tamás ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b Department of Family Medicine ^*  (Hungary)

^c EGIS PHARMACEUTICALS LTD   (Hungary)

^d Division of Clinical Pharmacology   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ANXIOLYTIC AGENT; DRUG METABOLITE; NERISOPAM;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG METABOLISM; FIRST PASS EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

EID: 0344474671     PISSN: 14608081     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Böniche, V. R., Reif, W. (1953) Enzymatische inaktivierung von isonicotinsaure-hydrazid im menschlichen und tierischen organizmus. Arch. Exp. Pathol. Pharmacol. 220: 321-333
2. Gibaldi, M., Perrier, D. (eds) (1982) Drug and Pharmaceutical Sciences, Pharmacokinetics. Marcel Dekker, New York, pp 239-296
3. Horváth, K., Andrási, F., Berzsenyi, P., Pártfalusi, M., Patthy, M., Szabó, G., Sebestyén, L., Bagdy, E., Körösi, J., Botka, P., Hámori, T., Láng, T. (1989) A new psychoactive 5H-2,3-benzodiazepine with a unique spectrum of activity. Arzneim. Forsch. Drug Res. 39: 894-899
4. Horváth, K., Andrási, F., Botka, P., Hámori, T. (1992) Anxiolytic profile of girisopam and GYKI 52322 (EGIS-6775). Comparison with chlordiazepoxide and buspirone. Acta Physiologica Hungarica 79: 153-161
5. Hughes, H. B., Biehl, J. P., Jones, A. P., Schmidt, L. H. (1954) Metabolism of isoniasid in man as related to the occurrence of peripheral neuritis. Am. Rev. Tuber. 70: 266-273
6. Riegelman, S., Collier, P. (1980) The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time. J. Pharmacokinet. Biopharm. 8: 509
7. Róna, K., Ary, K., Gachályi, B., Klebovich, I., Tomori, É. (1996) Simultaneous determination of nerisopam, a novel anxiolytic agent showing polymorphic metabolism, and its N-acetyl metabolite from human plasma by a validated high-performance liquid chromatographic method. J. Chromatogr. B: Biomed. Appl. 678: 63-72
8. Wagner, J. G. (1971) Biopharmaceutics and relevant pharmacokinetics. Drug Intelligence, Hamilton, Illinois