Clinical pharmacokinetics and metabolism of paclitaxel after a three-hour infusion: Comparison of two preparations

Journal of Oncology Pharmacy Practice

Volumn 9, Issue 4, 2003, Pages 129-136

  Czejka, Martin ^a,d   Schueller, Johannes ^b   Schnait, Heinz ^c   Springer, Beate ^b   Eder, Isabella ^d  

^a UNIVERSITY OF VIENNA   (Austria)

^b Rudolfstiftung   (Austria)

^c Research Initiative Ebewe   (Austria)

^d AUS Society of Applied Pharmaco   (Austria)

Author keywords

Metabolism; Paclitaxel; Pharmacokinetics; Test prepation

Indexed keywords

CITRIC ACID; DRUG METABOLITE; EBETAXEL; PACLITAXEL; PACLITAXEL DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BREAST CANCER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG INFUSION; DRUG METABOLISM; HUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

EID: 0344465954     PISSN: 10781552     EISSN: None     Source Type: Journal    
DOI: 10.1191/1078155203jp113oa     Document Type: Article

References (10)

1. Rowinsky EK. Paclitaxel: pharmacology and metabolism In McGuire WP, Rowinsky EK eds. Paclitaxel in cancer treatment. New York: Marcel Dekker Inc., 1995: 91-119.
2. Terwogt JM, Nuijen B, Huinik WW. Antitumor treatment: alternative formulations of paclitaxel. Cancer Treat Rev 1997; 23: 87-95.
3. Eisenhauer EA, Vermorken JB. The taxoids: comparative clinical pharmacology and therapeutic potential. Drugs 1998; 55: 5-30.
4. Huizing MT, Keung AC, Rosing H. Pharmacokinetics of paclitaxel and metabolites in a randomised comparative study in platinum pretreated ovarian cancer patients. J Clin Oncol 1993; 11: 2127-35.
5. Sonnichsen DS, Hurwitz CA, Pratt CB. Saturable pharmacokinetics and paclitaxel pharmacodynamics in children with solid tumours. J Clin Oncol 1994; 12: 532-38.
6. Gianni L, Kearns CM, Giani A. Nonlinear pharmacokinetics and metabolism of paclitaxel and its pharmacokinetic/pharmacodynamic relationships in humans. J Clin Oncol 1995; 13: 180-90.
7. Monsarrat B, Mariel E, Crois S. Taxol metabolism: Isolation and identification of three major metabolites in rat bile. Drug Metab Dispos 1990; 18: 895-90.
8. Huizing MT, Vermorken JB, Rosing H. Pharmacokinetics of paclitaxel and three major metabolites in patients with advanced breast carcinoma refractory to anthraxine therapy treated with a 3 hour paclitaxel infusion: a European Cancer Center (ECC) trial. Ann Oncol 1995; 6: 699-704.
9. GN Kumar, UK Walle, KN Bhalla. Binding of taxol to human plasma, albumin and alpha-1-acid glycoprotein. Res Comm Chem Pathol Pharm 1993; 80: 337-44.
10. Ciba Geigy Scientific Tables. Haematology and Human Genetics, Volume 2. Basel: Ciba Geigy Ltd, 1983: 66-67.