A new method for estimating the importance of hydrogen-bonding groups in the binding site of a protein

Journal of Computer-Aided Molecular Design

Volumn 17, Issue 7, 2003, Pages 401-414

  Kelly, Matthew D ^a   Mancera, Ricardo L ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b De Novo Pharmaceuticals   (United Kingdom)

Author keywords

Binding site; Hydrogen bond; Structure based drug design

Indexed keywords

LIGANDS; PROTEINS;

BINDING POCKETS; BINDING-SITES; BONDING REGION; CRYSTALS STRUCTURES; DESIGN STRATEGIES; HYDROGEN-BONDING STRENGTH; PRIORITIZATION; PROTEIN-LIGAND INTERACTIONS; STRUCTURE BASED DRUG DESIGNS; STRUCTURE-BASED DESIGNS;

HYDROGEN BONDS;

LIGAND; NEW DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; HYDROGEN BOND; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

EID: 0344465830     PISSN: 0920654X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1027346709963     Document Type: Article

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