Antiischemic effect of monophosphoryl lipid A in conscious rabbits with hypercholesterolemia and atherosclerosis

Journal of Cardiovascular Pharmacology

Volumn 32, Issue 2, 1998, Pages 206-212

  Szilvássy, Zoltán ^a,c   Ferdinandy, Péter ^a   Cluff, Christopher W ^b   Elliott, Gary T ^b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b Ribi ImmunoChem Inc   (United States)

^c UNIVERSITY OF PÉCS   (Hungary)

Author keywords

MLA; Myocardial ischemia; Preconditioning mimetic; Ventricular pacing

Indexed keywords

PHOSPHORYL LIPID A;

ANIMAL EXPERIMENT; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DRUG EFFECT; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REFRACTORY PERIOD; HEART PROTECTION; HEART VENTRICLE PACING; HYPERCHOLESTEROLEMIA; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ARTERIOSCLEROSIS; ELECTROPHYSIOLOGY; HEART; HEMODYNAMIC PROCESSES; HYPERCHOLESTEROLEMIA; LIPID A; MALE; MYOCARDIAL ISCHEMIA; PROTECTIVE AGENTS; RABBITS;

EID: 0344447040     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199808000-00006     Document Type: Article

References (24)

1. Szilvassy Z, Ferdinandy P, Bor P, Jakab I, Lonovics J, Koltai M. Ventricular overdrive pacing-induced anti-ischemic effect: a conscious rabbit model of preconditioning. Am J Physiol 1994;266: H2033-41.
2. Szekeres L, Papp JGy, Szilvássy Z, Udvary É, Végh Å. Moderate stress by cardiac pacing may induce both short term and long term cardioprotection. Cardiovasc Res 1993;27:593-6.
3. Szilvassy Z, Ferdinandy P, Szilvassy J, et al. Loss of preconditioning in atherosclerotic rabbits: the role of hypercholesterolaemia. J Mol Cell Cardiol 1995;27:2559-69.
4. Szekeres L, Szilvassy Z, Ferdinandy P, Nagy I, Karcsu S, Csati S. Delayed cardiac protection against harmful consequences of stress can be induced in experimental atherosclerosis in rabbits. J Mol Cell Cardiol 1997;29:1977-83.
5. Parratt JR. Possibilities for the pharmacological exploitation of ischaemic preconditioning. J Mol Cell Cardiol 1995;27:991-1000.
6. Elliott GT. Pharmacologic myocardial preconditioning with monophosphoryl lipid A (MLA) reduces infarct size and stunning in dogs and rabbits. Ann N Y Acad Sci 1996;793:386-99.
7. Nelson DW, Brown JM, Banerjee A, et al. Pretreatment with a non-toxic derivative of endotoxin induces functional protection against cardiac ischaemia/reperfusion injury. Surgery 1991;110:365-9.
8. Yao Z, Auchampach JA, Pieper GM, Gross GJ. Cardioprotective effects of monophosphoryl lipid A, a novel endotoxin analogue, in the dog. Cardiovasc Res 1993;27:832-8.
9. Elliott GT, Zhao L, McLeod RA, Floyd KW, Graves GM. Cardiac functional preservation by monophosphoryl lipid A in a rabbit model of prolonged regional cardiac ischemia and reperfusion. Int J Immunother 1995;11:39-48.
10. Zhao L, Kirsch C, Hagen SR, Elliott GT. Preservation of global cardiac function in the rabbit following protracted ischaemia/reperfusion using monophosphoryl lipid A (MLA). J Mol Cell Cardiol 1996;28:197-208.
11. Przyklenk K, Zhao L, Kloner R, Elliott GT. Cardioprotection with ischemic preconditioning and MLA: role of adenosine-regulating enzymes? Am J Physiol 1996;271:H1004-14.
12. Szilvássy Z, Jakab I, Bor P, et al. Anti-ischemic effect of cicletanine in conscious rabbits: a possible relation to changes of cardiac-cyclic nucleotide content. Coron Artery Dis 1993;4:443-52.
13. Wallenstein S, Zucker CL, Fleiss JL. Some statistical methods useful in circulation research. Circ Res 1980;47:1-9.
14. Murry CE, Richard VJ, Reimer KA, Jennings RB. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode. Circ Res 1990;66: 913-31.
15. Kitazake M, Hori M, Takashima S, Sato H, Inoue M, Kamada T. Ischemic preconditioning increases adenosine release and 5′-nucleotidase activity during myocardial ischemia and reperfusion in dogs. Circulation 1993;87:208-15.
16. Mizumura T, Nithipatikom K, Gross GJ. Bimakalim, an ATP-sensitive potassium channel opener mimics the effect of preconditioning to reduce infarct size, adenosine release and neutrophil function in dogs. Circulation 1995;92:1236-45.
17. Rowland RT, Cleveland JC, Meng X, Ho L, Harken AH, Brown JM. A single endotoxin challenge induces delayed myocardial protection against infarction. J Surg Res 1996;29:813-9.
18. Zhao L, Weber P, Smith JR, Comerfors ML, Elliott GT. Role of inducible nitric oxide synthase in pharmacological "preconditioning" with monophosphoryl lipid A. J Mol Cell Cardiol 1997;29: 1567-76.
19. Szilvássy Z, Koltai M, Ferdinandy P, et al. Cromakalim and cicletanine against pacing-induced myocardial ischemia in conscious rabbits. Life Sci 1994;54:125-30.
20. Ferdinandy P, Szilvássy Z, Balogh N, et al. Nitric oxide is involved in active preconditioning in isolated working rat hearts. Ann N Y Acad Sci 1996;793:489-93.
21. Bolli R, Bhatti ZA, Tang X-L, et al. Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by the generation of nitric oxide. Circ Res 1997;81:42-52.
22. Vegh A, Papp JG, Parratt JR. Pretreatment with monophosphoryl lipid C (MPL-C) reduces ischemia-reperfusion-induced arrhythmias in dogs [Abstract]. J Mol Cell Cardiol 1996;28:A56.
23. Szilvassy Z, Nagy I, Szilvassy J, Jakab I, Csati S, Lonovics J. Impaired nitrergic relaxation of the sphincter of Oddi of hyperlipidaemic rabbits. Eur J Pharmacol 1996;301:R17-8.
24. Hoshida S, Nishida M, Yamashita N, et al. Amelioration of severity of myocardial injury by a nitric oxide donor in rabbits fed a cholesterol-rich diet. J Am Coll Cardiol 1996;27:902-9.