Synthesis and Evaluation of PEG414, a Novel Formulating Agent that Avoids Analytical Problems Associated with Polydisperse Vehicles Such as PEG400

Journal of Pharmaceutical Sciences

Volumn 92, Issue 12, 2003, Pages 2512-2518

  Temesi, David ^a   Law, Brian ^a   Howe, Nicholas ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Dose vehicle; HPLC MS; Ion suppression; PEG400; PEG414

Indexed keywords

ACETAZOLAMIDE; DANAZOL; DISULFARIM; GRISEOFULVIN; MACROGOL 400; MACROGOL DERIVATIVE; MEGESTROL ACETATE; PHENYTOIN; POLYETHYLENE GLYCOL 414; PROBUCOL; UNCLASSIFIED DRUG;

ARTICLE; DRUG FORMULATION; DRUG SYNTHESIS; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

EID: 0344443698     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10514     Document Type: Article

References (13)

1. Burhman DL, Price PI, Rudewicz PJ. 1999. Quantitation of Sr 27417 in human plasma using electrospray liquid chromatography tandem mass spectrometry: A study of ion suppression. J Am Soc Mass Spectrom 7:1099-1105.
2. Matuszewski BK, Constanzer ML, Chavez-Eng CM. 1998. Matrix effects in quantitative LC/MS/MS analyses of biological fluids: A method for determination of finasteride in human plasma at picogram per milliliter concentrations. Anal Chem 70:882-889.
3. Beaudry F, Le Blanc JCY, Coutu M, Brown NK. 1998. In vivo pharmacokinetic screening in cassette dosing experiments; the use of on-line Pprospekt liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry technology in drug discovery. Rapid Commun Mass Spectrom 12:1216-1222.
4. Law B, Temesi D. 2000. Factors to consider in the development of generic bioanalytical high-performance liquid chromatographic-mass spectrometric methods to support drug discovery. J Chromatogr B Biomed Sci Appl 748:21-30.
5. Toreson H. 1999. 16th Montreux LC-MS symposium, Hilton Head, SC.
6. Tong XS, Wang J, Zheng S, Pivnichny JV, Griffin PR, Shen X, Donnelly M, Vakerich K, Nunes C, Fenyk-Melody J. 2002. Effect of signal interference from dosing excipients on pharmacokinetic screening of drug candidates by liquid chromatography/mass spectrometry. Anal Chem 74:6305-6313.
7. Smyth HF, Carpenter CP, Weil CS. 1955. The chronic oral toxicology of the polyethylene glycols. J Am Pharm Assoc Sci 64:27-31.
8. Hermansky SJ, Neptun DA, Loughran KA, Leung HW. 1995. Effects of polyethylene glycol 400 (PEG 400) following 13 weeks of gavage treatment in Fischer-344 rats. Food Chem Toxicol 33:139-149.
9. Wade A, Weller PJ. 1994. Editors Handbook of Pharmaceutical Excipients, 2nd ed. London: Pharmaceutical Press, pp 355-361.
10. Montaguti P, Melloni E, Cavalletti E. 1994. Acute intravenous toxicity of dimethyl sulphoxide, polyethylene glycol 400, dimethylformamide, absolute ethanol, and benzyl alcohol in inbred mouse strains. Arzneimittelforschung 44:566-570.
11. Yalkowsky SH, Roseman TJ. 1981. Solubilisation of drugs by cosolvents. In: Ylakowsky SH, editor. Techniques of solubilisation of drugs. New York: Marcel Dekker, pp 91-134.
12. Ma TY, Hollander D, Krugliak P, Katz K. 1990. PEG 400, a hydrophilic molecular probe for measuring intestinal permeability. Gastroenterology 98:39-46.
13. He YL, Murby S, Warhurst G, Gifford L, Walker D, Ayrton J, Eastmond R, Rowland M. 1998. Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides. J Pharm Sci 87:626-633.