Pharmacokinetics and pharmacodynamics of mivacurium in patients phenotypically heterozygous for the usual and atypical plasma cholinesterase variants (UA)

Acta Anaesthesiologica Scandinavica

Volumn 47, Issue 10, 2003, Pages 1219-1225

  Ostergaard D ^b   Viby Mogensen, J ^a   Rasmussen, S N ^c   Gatke M R ^a   Pedersen, N A ^b   Skovgaard, L T ^d  

^a Copenhagen University Hospital ^*  (Denmark)

^b GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d Department of Environmental Health   (Denmark)

Author keywords

Butyrylcholinesterase; Cholinesterase; Cholinesterase variants; Dose response curves; Enzymes; Genetic factors; Mivacurium; Neuromuscular relaxants; Pharmacodynamics; Pharmacokinetics; Pharmacology; Pseudocholinesterase; Stereo isomers

Indexed keywords

CHOLINESTERASE; MIVACURIUM;

ADULT; AGED; ANESTHETIC RECOVERY; ARTICLE; CIS ISOMER; CIS TRANS ISOMERISM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG POTENCY; ENZYME ACTIVITY; FEMALE; HETEROZYGOTE; HUMAN; ISOMER; MALE; NERVE STIMULATION; NEUROMUSCULAR BLOCKING; PHENOTYPE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0344442826     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1399-6576.2003.00243.x     Document Type: Article

References (22)

1. Savarese JJ, Ali HH, Basta SJ et al. The clinical neuromuscular pharmacology of mivacurium chloride (BW B1090U). Anesthesiology 1988; 68: 723-32.
2. Lien CA, Schmith VD, Embree PB, Belmont MR, Wargin WA, Savarese JJ. The pharmacokinetics and pharmacodynamics of the stereoisomers of mivacurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia. Anesthesiology 1994; 80: 1296-302.
3. Østergaard D, Jensen FS, Jensen E, Skovgaard LT, Viby Mogensen J. Mivacurium-induced neuromuscular blockade in patients with atypical plasma cholinesterase. Acta Anaesthesiol Scand 1993; 37: 314-8.
4. Whitaker M. Cholinesterase. In: Beckman L, ed. Basel: Karger, 1986.
5. Viby-Mogensen J, Hanel HK. A Danish cholinesterase research unit. Acta Anaesthesiol Scand 1977; 21: 371-80.
6. Jensen FS, Skovgaard LT, Viby-Mogensen J. Identification of human plasma cholinesterase variants in 6.688 individuals using biochemical analysis. Acta Anaesthesiol Scand 1995; 39: 157-62.
7. Viby-Mogensen J, Engbæk J, Eriksson LI et al. Good clinical research practice (GCRP) in pharmacodynamic studies of neuromuscular blocking agents. Acta Anaesthesiol Scand 1996; 40: 59-74.
8. Viby-Mogensen J, Østergaard D, Donati F et al. Pharmacokinetic studies of neuromuscular blocking agents: Good clinical research practice (GCRP). Acta Anaesthesiol Scand 2000; 44: 1169-90.
9. D'Argenio DZ, Schumitzky A. ADAPT 11 user's guide. Los Angeles: Biomedical Simulation Resources, University of Southern California, 1992.
10. Ørding H, Skovgaard LT, Engbæk J, Viby-Mogensen J. Dose-response curves for vecuronium during halothane and neurolept anaesthesia: Single bolus versus cumulative method. Acta Anaesthesiol Scand 1985; 29: 121-4.
11. Østergaard D, Viby-Mogensen J, Pedersen NA, Holm H, Skovgaard LT. Pharmacokinetics and pharmacodynamics of mivacurium in young adult and elderly patients. Acta Anaesthesiol Scand 2002; 46: 684-91.
12. Caldwell JE, Kitts JB, Heier T, Fahey MR, Lynam DP, Miller RD. The dose-response relationship of mivacurium chloride in humans during nitrous oxide-narcotic anesthesia in adult surgical patients. Anesthesiology 1989; 70: 31-5.
13. Diefenbach C, Mellinghoff H, Lynch J, Buzello W. Mivacurium: Dose-response relationship and administration by repeated injection or infusion. Anesth Analg 1992; 74: 420-3.
14. Østergaard D, Jensen FS, Skovgaard LT, Viby-Mogensen L. Dose-response relationship for mivacurium in patients with phenorypically abnormal plasma cholinesterase activity. Acta Anaesthesiol Scand 1995; 39: 1016-8.
15. Goudsouzian N, Chakravorti S, Denman W, Schwartz A, Yang HS, Cook DR. Prolonged mivacurium infusion in young and elderly adults. Can J Anesth 1997; 44: 955-62.
16. Østergaard D, Ibsen M, Skovgaard LT, Viby-Mogensen J. Plasma cholinesterase activity and duration of action of mivacurium in phenotypically normal patients. Acta Anaesthesiol Scand 2002; 46: 679-83.
17. Maddineni VR, Mirakhur RK, McCoy EP, Sharpe TD. Neuromuscular and haemodynamic effects of mivacurium in elderly and young patients. Br J Anaesth 1994; 73: 608-12.
18. Servin F, Lavaut E, Peytavin G, Farinotti R, Desmonts JM. A pharmacokinetic and dynamic study of mivacurium infusion in elderly patients. Anesthesiology 1997; 87: A855 (Abstract).
19. Head-Rapson AG, Devlin JC, Parker CJR, Hunter JM. Pharmacokinetics and pharmacodynamics of the three isomers of mivacurium in health, in end-stage renal failure and in patients with impaired renal function. Br J Anaesth 1995; 75: 31-6.
20. Østergaard D, Rasmussen SN, Rohde M, Viby-Mogensen J. The pharmacokinetics and pharmacodynamics of mivacurium in patients homozygous for the atypical plasma cholinesterase gene. Anesthesiology 1997; V87 (3A): A854 (Abstract).
21. Head-Rapson AG, Devlin JC, Parker CJR, Hunter JM. Pharmacokinetics of the three isomers of mivacurium and pharmacodynamics of the chiral mixture in hepatic cirrhosis. Br J Anaesth 1994; 73: 613-8.
22. Lacroix M, Donati F, Varin F. Pharmacokinetics of mivacurium isomers and their metabolites in healthy volunteers after intravenous bolus administration. Anesthesiology 1997; 86: 322-30.