Vagus nerve stimulation for essential tremor: A pilot efficacy and safety trial

Neurology

Volumn 61, Issue 10, 2003, Pages 1401-1405

  Handforth, A ^a,g   Ondo, W G ^d   Tatter, S ^e   Mathern, G W ^a,b   Simpson Jr , R K ^d   Walker, F ^e   Sutton, J P ^c   Hubble, J P ^f   Jankovic, J ^d  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e WAKE FOREST UNIVERSITY   (United States)

^f OHIO STATE UNIVERSITY   (United States)

^g VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRIMIDONE; PROPRANOLOL;

ACCELEROMETER; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; ELECTRODE; ESSENTIAL TREMOR; FEMALE; HUMAN; MALE; MULTICENTER STUDY; OPEN STUDY; PRIORITY JOURNAL; RATING SCALE; SAFETY; SCORING SYSTEM; TREATMENT OUTCOME; VAGUS NERVE; VAGUS NERVE STIMULATION; VIDEOTAPE;

EID: 0344442691     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000094355.51119.D2     Document Type: Article

References (18)

1. Jenkins IH, Bain PG, Colebatch JG, et al. A positron emission tomography study of essential tremor: evidence for overactivity of cerebellar connections. Ann Neurol 1993;34:82-90.
2. Boecker H, Wills AJ, Ceballos-Baumann A, et al. The effect of ethanol on alcohol-responsive essential tremor: a positron emission tomography study. Ann Neurol 1996;39:650-658.
3. Simantov R, Snyder SH, Oster-Granite ML. Harmaline-induced tremor in the rat: abolition by 3-acetylpyridine destruction of cerebellar climbing fibers. Brain Res 1976;114:144-151.
4. Perrin J, Crousillat J. Responses of single units in the inferior olive nucleus to stimulation of the splanchnic afferents in the cat. J Auton Nerv Syst 1980;2:15-22.
5. Tong G, Robertson LT, Brons J. Vagal and somatic representation by the climbing fiber system in lobule V of the cat cerebellum. Brain Res 1991;552:58-66.
6. Hennemann HE, Bubia FJ. Vagal representation in the cerebellum of the cat. Pflugers Arch 1978;375:119-123.
7. Okahara K, Nisimaru N. Climbing fiber responses evoked in lobule VII of the posterior cerebellum from a vagal nerve in rabbits. Neurosci Res 1991;12:232-239.
8. Vagus Nerve Stimulation Study Group. A randomized controlled trial of chronic vagus nerve stimulation for treatment of medically intractable seizures. Neurology 1995;45:224-230.
9. Handforth A, DeGiorgio CM, Schachter SC, et al. Vagus nerve stimulation therapy for partial-onset seizures. A randomized active-control trial. Neurology 1998;51:48-55.
10. Schachter SC, Saper CB. Vagus nerve stimulation. Epilepsia 1998;39:677-686.
11. 15O blood flow imaging. Neurosurgery 1996;39:426-430.
12. Henry TR, Votaw JR, Pennell PB, et al. Acute blood flow changes and efficacy of vagus nerve stimulation in partial epilepsy. Neurology 1999;52:1166-1173.
13. Handforth A, Krahl SE. Suppression of harmaline-induced tremor in rats by vagus nerve stimulation. Mov Disord 2001;16:84-88.
14. Deuschl G, Bain P, Brin M, and Ad Hoc Scientific Committee. Consensus statement of the Movement Disorders Society on tremor. Mov Disord 1998;13(suppl 3):2-23.
15. Terry RS, Tarver WB, Zabara J. The implantable Neurocybernetic Prosthesis System. Pacing Clin Electrophysiol 1991;14:86-93.
16. Fahn SE, Tolosa E, Marin C. Clinical rating scale for tremor. In: Jankovic J, Tolosa E, eds. Parkinson's disease and movement disorders. 2nd ed. Baltimore: Williams & Wilkins, 1993:271-280.
17. Jankovic J, Schwartz K, Clemence W, Aswad A, Mordaunt J. A randomized, double-blind, placebo controlled study to evaluate botulinum toxin type A in essential hand tremor. Mov Disord 1996;11:250-256.
18. Gehan EA. The determination of the number of patients required in a preliminary and followup trial of a new chemotherapeutic agent. J Chronic Dis 1961;13:346-353.