Newly Identified Steroid Hormone in Urine of Patients with Cushing's Syndrome: 3α, 11β-Dihydroxy-4-Androsten-17-one

Endocrine Journal

Volumn 50, Issue 5, 2003, Pages 571-577

  Suzuki, Takashi ^a   Ueki, Makoto ^b   Sakuta, Hidenari ^a   Fujisaki, Makoto ^b   Yasuda, Hiroko ^a   Ito, Teizo ^a  

^a Japan Self Defense Forces Central Hospital   (Japan)

^b LSI MEDIENCE CORPORATION   (Japan)

Author keywords

17 Ketosteroid; Cushing's syndrome; Identification; Steroid hormone; Urine

Indexed keywords

3ALPHA,11BETA DIHYDROXY 4 ANDROSTEN 17 ONE; STEROID HORMONE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CHEMICAL STRUCTURE; CONTROLLED STUDY; CUSHING SYNDROME; GAS CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; MOLECULAR WEIGHT; URINALYSIS;

ANDROSTENES; CHROMATOGRAPHY, GAS; CUSHING SYNDROME; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MOLECULAR STRUCTURE; MOLECULAR WEIGHT;

EID: 0344441411     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.50.571     Document Type: Article

References (15)

1. Kirk LF Jr, Hash RB, Katner HP, Jones T (2000) Cushing's disease: clinical manifestations and diagnostic evaluation. Am Fam Physician 62: 1119-1127.
2. Mengden T, Hubmann P, Muller J, Greminger P, Vetter W (1992) Urinary free cortisol versus 17-hydroxycorticosteroids: a comparative study of their diagnostic value in Cushing's syndrome. Clin Invest 70: 545-548.
3. Billon-Rey S, Beylot M, Mathian B, Patricot MC, Berthezene F, Morrnex R, Revol A (1986) Comparison between the value of urinary free cortisol and 17-hydroxycorticosteroids for the diagnosis of Cushing's syndrome. Presse Med 15: 985-968.
4. Suzuki T, Sakuta T, Nakagawa K, Yamada K, Ito T (1993) Unidentified steroid hormone of Cushing's Syndrome and Disease (Report 2). Folia Endocrinol 69: 349.
5. Suzuki T, Sakuta H, Nakagawa K, Iwata J, Ito T (1993) Unidentified steroid hormone of Cushing's syndrome and disease. Folia Endocrinol 69: 1139-1152.
6. Iwata J, Morita H, Yasuda K, Kuwayama A, Suzuki T, Demura H (1995) Daily excretion levels of an unidentified ketosteroid in the urine of patients with Cushing's syndrome and healthy subjects measured by a new method. Endocr J 42: 449-453.
7. Iwata J, Suga T (1989) Direct determination of four sulfates and seven glucuronides of 17-oxosteroids in urine by fluorescence " high-performance" liquid chromatography. Clin Chem 35: 794-799.
8. Suzuki T, Sakuta H, Nakagawa K, Yamada K, Ito T (1995) Unknown peak found in 17-ketosteroid fraction of urine from Cushing's syndrome. Part 3. Ann Res Report SDFCH 96-103.
9. Ibayashi H (1971) Synthesis and metabolism of steroid hormone. In: Kyousuke Tsuda (ed) Steroid. Asakurashoten, Tokyo, 153-301.
10. Hill RA, Kirk SN, Makin HLJ, Murphy GM (1991) 3,11-dihydroxy-4-androsten-17-one. In: Dictionary of Steroids. Chapman and Hall, Great Britain, D-00293.
11. Fukushima DK, Dobriner S, Bradlow HL, Zumoff B, Hellman L, Gallagher TF (1966) New metabolites of 11β-hydroxy-Δ4-androsten-3,17-dione. Biochemistry 5: 1779-1783.
12. Fukushima DK, Dobriner S, Bradlow HL (1966) Synthesis and reactions of 3,11β-dihydroxy-Δ4-androsten-17-one. Biochemistry 5: 1783-1789.
13. Slaunwhite WR, Neely JL, Sandberg AA (1964) The metabolism of 11-oxyandrogens in human subjects. The influence of oxygen at C11 upon the stereochemical reduction of ring A in vivo. Steroids 3: 391-416.
14. Gallagher TF, Fukushima DK, Noguchi S, Fishman J, Bradlow HL, Cassouto J, Zumoff B, Hellman L (1966) Recent studies in steroid hormone metabolism in man. Recent Prog Horm Res 22: 283-303.
15. Bradlow HL, Zumoff B, Fukushima DK, Hellman L, Gallagher TF (1966) Metabolism of 11β-hydroxy-Δ4-androstene-3,17-dione: Effect of thyroid hormone. J Clin Endocrinol Metab 26: 949-954.