Differential effects of sodium nitroprusside and hydralazine in a rat model of topical FeCl3-induced carotid artery thrombosis

Thrombosis Research

Volumn 111, Issue 1-2, 2003, Pages 59-64

  Robinson, Mary A ^a   Welsh, Denise C ^a   Bickel, Denise J ^a   Lynch Jr , Joseph J ^a   Lyle, Elizabeth A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

FeCl3 induced thrombosis; Hydralazine; Platelet aggregation; Sodium nitroprusside; Vasoconstriction

Indexed keywords

ADENOSINE DIPHOSPHATE; ARACHIDONIC ACID; COLLAGEN; FERRIC CHLORIDE; HYDRALAZINE; NITROPRUSSIDE SODIUM;

ANIMAL MODEL; ARTICLE; BLOOD VESSEL TONE; CAROTID ARTERY THROMBOSIS; CONTROLLED STUDY; DISSOCIATION; IN VIVO STUDY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOGENESIS; VASOCONSTRICTION; VELOCITY; VESSEL;

EID: 0344440939     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2003.08.012     Document Type: Article

References (30)

1. Kurz K.D., Main B.W., Sandusky G.E. Rat model of arterial thrombosis induced by ferric chloride. Thromb. Res. 60:1990;269-280.
2. Neises B., Broersma R.J., Tarnus C., et al. Synthesis and comparison of tripeptidylfluoroalkane thrombin inhibitors. Bioorg. Med. Chem. 3:1995;1049-1061.
3. ab- fragment of a PAI-1 inhibiting antibody reduces thrombus size and restores blood flow in a rat model of arterial thrombosis. Thromb. Haemost. 77:1997;964-969.
4. Schumacher W.A., Heran C.L., Steinbacher T.E., Youssef S., Ogletree M.L. Superior activity of a thromboxane receptor antagonist as compared with aspirin in rat models of arterial and venous thrombosis. J. Cardiovasc. Pharmacol. 22:1993;526-533.
5. Finkle C.D., St. Pierre A., Leblond L., Deschenes I., DiMaio J., Winocour P.D. BCH-2763, a novel potent parenteral thrombin inhibitor, is an effective antithrombotic agent in rodent models of arterial and venous thrombosis - comparisons with heparin, r-hirudin, hirulog, inogatran and argatroban. Thromb. Haemost. 79:1998;431-438.
6. Lockyer S., Kambayashi J. Demonstration of flow and platelet dependency in a ferric chloride-induced model of thrombosis. J. Cardiovasc. Pharmacol. 33:1999;718-725.
7. Lyle E.M., Lewis S.D., Lehman E.D., et al. Assessment of thrombin inhibitor efficacy in a novel rabbit model of simultaneous arterial and venous thrombosis. Thromb. Haemost. 79:1998;656-662.
8. Fiscus R.R. Molecular mechanisms of endothelium-mediated vasodilation. Semin. Thromb. Hemost. 14:1988;12-22.
9. Katsuki S., Arnold W., Mittal C., et al. Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin, and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. J. Cycl. Nucleotide Res. 3:1977;23-35.
10. Walker H.J., Geniton D.J. Vasodilator therapy and the anesthetist: a review of nitroprusside, labetolol, hydralazine, and nitroglycerin. J. Am. Assoc. Nurse Anesth. 57:1989;435-444.
11. 2 biosynthesis. Biochem. Biophys. Res. Commun. 84:1978;1112-1118.
12. Greenwald J.E., Wong L.K., Alexander M., Bianchine J.R. In vivo inhibition of thromboxane biosynthesis by hydralazine. Samuelsson B., Ramwell P.W. Advances in Prostaglandin and Thromboxane Research. vol. 6:1980;293-295 Raven Press, New York.
13. 2 in hypertension. Biomed. Biochim. Acta. 43:1984;S208-S211.
14. Luderer J.R., Demers L.M., Janson R.W., et al. The effect of hydralazine on arachidonic acid metabolism in isolated, washed human platelets. Res. Commun. Chem. Pathol. Pharmacol. 28:1980;43-52.
15. Ambler J., Sarwar M., Smith J.R., et al. The platelet inhibitory effect of hydralazine: comparison with hypotensive effects in the rat. Thromb. Res. 32:1983;239-243.
16. Burns T.S., Saunders R.N. Antiplatelet activity of hydralazine. Thromb. Res. 16:1979;837-842.
17. Folts J.D. Inhibition of platelet function in vivo or in vitro by organic nitrates. J. Am. Coll. Cardiol. 18:1991;1537-1538.
18. Radomski M.W., Palmer R.M.J., Moncada S. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. PNAS USA. 87:1990;5193-5197.
19. Rovin J.D., Stamler J.S., Loscalzo J., et al. Sodium nitroprusside, an endothelium-derived relaxing factor congener, increases platelet cyclic GMP levels and inhibits epinephrine-exacerbated in vivo platelet thrombus formation in stenosed canine coronary arteries. J. Cardiovasc. Pharmacol. 22:1993;626-631.
20. Spankova H., Mlejnkova M., Rysanek K., et al. The action of hydrazine hypotensive drugs upon adrenalin and ADP induced platelet aggregation. Act. Nerv. Super. (Praha). 12:1970;79-80.
21. Srivastava K.C. Effects of dipyridamole, nifedipine, verapamil, hydralazine, and propranolol on the formation of prostacyclin and thromboxane in a coupled system of platelets and rat aorta. Prostaglandins Leukot. Med. 23:1986;31-36.
22. Stamler J.S., Loscalzo J. The antithrombotic effects of organic nitrates. Trends Cardiovasc. Med. 1:1991;346-353.
23. Stamler J.S., Loscalzo J. The antiplatelet effects of organic nitrates and related nitroso compounds in vitro and in vivo and their relevance to cardiovascular disorders. J. Am. Coll. Cardiol. 18:1991;529-536.
24. Wang G.-R., Zhu Y., Halushka P.V., et al. Mechanism of platelet inhibition by nitric oxide: in vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase. PNAS. 95:1998;4888-4893.
25. Ally A.I., Horrobin D.F. Hydralazine inhibits vascular reactivity by a mechanism independent of vascular prostaglandin synthesis: role of thromboxane synthetase in blocking hydralazine actions. Res. Commun. Chem. Pathol. Pharmacol. 53:1986;39-63.
26. Folts J.D., Stamler J., Loscalzo J. Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries. Circulation. 83:1991;2122-2127.
27. Lam J.Y.T., Chesebro J.H., Fuster V. Platelets, vasoconstriction, and nitroglycerin during arterial wall injury. A new antithrombotic role for an old drug. Circulation. 78:1988;712-716.
28. Werns S.W., Rote W.E., Davis J.H., et al. Nitroglycerin inhibits experimental thrombosis and reocclusion after thrombolysis. Am. Heart J. 127:1994;727-737.
29. Mann K.G., Tracey P.B., Nesheim M.E. Assembly and function of prothrombinase complex on synthetic and natural membranes. Oates J.A., Hawiger J., Ross R. Interaction of platelets with the vessel wall. 1985;47-57 Waverly Press, Baltimore.
30. Mendelsohn M.E., O'Neill S., George D., et al. Inhibition of fibrinogen binding to human platelets by S-nitroso-N-acetylcysteine. J. Biol. Chem. 265:1990;19028-19034.