Growth hormone enhances regeneration of nitric oxide synthase-containing penile nerves after cavernous nerve neurotomy in rats

Journal of Urology

Volumn 160, Issue 5, 1998, Pages 1899-1904

  Jung, Gyung Woo ^a   Spencer, E Martine ^a   Lue, Tom F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Growth factors; Growth hormone; Impotence; Nitric oxide

Indexed keywords

GROWTH HORMONE; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; ELECTROSTIMULATION; ERECTILE DYSFUNCTION; HORMONAL REGULATION; MALE GENITAL SYSTEM FUNCTION; MOTOR NERVE; NERVE REGENERATION; NEURECTOMY; NEUROTRANSMITTER RELEASE; NONHUMAN; PELVIC NERVE; PELVIS SURGERY; PENIS; PENIS ERECTION; PRIORITY JOURNAL; RAT;

EID: 0344423819     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)62440-6     Document Type: Article

References (33)

1. Walsh, P. C. and Donker, P. J.: Impotence following radical prostatectomy: insight into etiology and prevention. J. Urol., 128: 492, 1982.
2. Walsh, P. C., Epstein, J. I. and Lowe, F. C.: Potency following radical prostatectomy with wide unilateral excision of the neurovascular bundle. J. Urol., 138: 823, 1987.
3. Catalona, W. J. and Basler, J. W.: Return of erections and urinary continence following nerve sparing radical retropubic prostatectomy. J. Urol., 150: 905, 1993.
4. Burnett, A. L., Lowenstein, C., J., Bredt, D. S., Chang, T. S. K. and Synder, S. H.: Nitric oxide: a physiologic mediator of penile erection. Science, 257: 401, 1992.
5. Kim, N., Azadzoi, K. M., Goldstein, I. and Saaenz de Tejada, I.: A nitric oxide-like factor mediates nonadrenergicnoncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. J. Clin. Invest., 88: 112, 1991.
6. Burnett, A. L., Tillman, S. L., Chang, T. S. K., Epstein, J. I., Lowenstein, C. J., Bredt, D. S., Synder, S. H. and Walsh, P. C.: Immunohistochemical localization of nitric oxide synthase in the autonomie innervation of the human penis. J. Urol., 150: 73, 1993.
7. Carrier, S., Zvara, P., Nunes, L., Kour, N. H., Rehman, J. and Lue, T. F.: Regeneration of nitric oxide synthase-containing nerves after cavernous nerve neurotomy in the rat. J. Urol., 153: 1722, 1995.
8. Carrier, S., Hricak, H., Lee, S. S., Baba, K. Morgan, D. M., Nunes, L., Ross, G. Y., Phillips, T. L. and Lue, T. F.: Radiation-induced decreases in nitric oxide synthase-containing nerves in the rat penis. Thera. Radio., 195: 95, 1995.
9. Vincent, S. R. and Hope, B. T.: Neurons that say NO. Trends Neurosci., 15: 108, 1992.
10. Hope, B. T., Michael, G. J., Knigge, K. M. and Vincent, S. R.: Neuronal NADPH diaphorase is a nitric oxide synthase. Neurobiology, 88: 2811, 1991.
11. Kanje, M., Skottner, A. and Lundborg, G.: Effects of growth hormone treatment on the regeneration of rat sciatic nerve. Brain Res., 475: 154, 1988.
12. Fernyhough, P., Willars, G. B., Lindsay, R. M. and Tomlinson, D. R.: Insulin and insulin-like growth factor I enhance regeneration in cultured adult rat sensory neurons. Brain Res., 607: 117, 1993.
13. Nachemson, A. K., Lundborg, G. and Hasson, H.: Insulin-like growth factor I promotes nerve regeneration: an experimental study on rat sciatic nerve. Growth Factors, 3: 309, 1990.
14. Van Wyk, J. J.: Somatomedins: biological actions and physiologic control mechanisms. In: Hormonal Proteins and Peptides. Edited by C. H. Li. New York: Academic, vol. 12, chap. 3, pp. 81-125, 1984.
15. Quinlan, D. M., Nelson, R. J., Partin, A. W., Mostwin, J. L. and Walsh, P. C.: The rat as a model for the study of penile erction. J. Urol., 141: 656, 1989.
16. Aim, P., Larsson, B., Ekbald, E., Sundler, F. and Andersson, K-E.: Immunohistochemical localization of peripheral nitric oxide synthase-containing nerves using antibodies raised against synthesized C-and N-terminal fragments of a cloned enzyme from rat brain. Acta Physiol. Scand., 148: 421, 1993.
17. Gulbenkian, S., Wharttton, J. and Polak, J. M.: The visualization of cardiovascular innervation in the guinea pig using an antiserum to protein gene product 9.5 (PGP 9.5).: J. Auton. Nerv. Syst., 18: 235, 1987.
18. Ignaro, L. J.: Endothelium-derived nitric oxide: pharmacology and relationship to the actions of organic nitrate esters. Pharm. Res., 6: 651, 1992.
19. Dawson, T. M., Bredt, D. S., Fotuhi, M., Hwang, P. M. and Synder, S. H.: Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc. Natl. Acad. Sci. USA, 88: 7797, 1991.
20. Lue, T. F., Zeineh, S. J., Schmit, R. A. and Tanagho, E. A.: Neuroanatomy of penile erection: its relevance to iatrogenic impotence. J. Urol., 131: 273 1984.
21. Lepor, H., Gregerman, M., Crosby, R., Mostofi, F. K. and Walsh, P. C.: Precise localization of the anatomic nerves from the pelvic plexus to the corpora cavernosa: a detailed anatomical study of the adult male pelvis. J. Urol., 133: 207, 1985.
22. Paick, J. S., Donatucci, C. F. and Lue, T. F.: Anatomy of cavernous nerves distal to prostate: microdissection study in adult male cadavers. Urology, 42: 145, 1993.
23. Breza, J., Aboseif, S. R., Orvis, B. R., Lue, T. F. and Tanagho, E. A.: Detailed anatomy of penile neurovascular structures: surgical significance. J. Urol., 141: 437, 1989.
24. Kredel, F. E. and Phemister, D. B.: Recovery of sympathetic nerve function in skin transplants. Arch. Neurol. Psych., 42: 403, 1939.
25. Gibson, G. R.: Impotence following fractured pelvis and ruptured urethra. Br. J. Urol., 42: 86, 1970.
26. Fernyhough, P., Willars, G. B., Lindsay, R. M. and Tomlinson, D. R.: Insulin and insulin-like growth factor I enhance regeneration in cultured adult rat sensory neurons. Brain Res., 607: 117, 1993.
27. Recio-Pinto, E., Rechler, M. M. and Ishii, D. N.: Effects of insulin, insulin-like growth factor II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons. J. Neurosci., 6: 1211, 1986.
28. Caroni, P. and Grandes, P.: Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors. J. Cell Biol., 110: 1307, 1990.
29. Kanje, M., Stottner, A. and Lundborg, G.: Effects of growth hormone treatment on the regeneration of rat sciatic nerve. Brain Res., 475: 254, 1988.
30. Sjöberg, J. and Kanje, M.: Insulin-like growth factor (IGF-I) as a stimulator of regeneration in the freeze-injured rat sciatic nerve. Brain Res., 485: 102, 1989.
31. Ding, Y., Wang, Y., Qin, B. and Li, J.: The major pelvic ganglion is the main source of nitric oxide synthase-containing nerve fibers in penile erectile tissue of the rat. Neurosci. Lett., 164: 187, 1993.
32. Keast, J. R.: A possible neural source of nitric oxide in the rat penis. Neurosci. Lett., 143: 69, 1992.
33. McNeill, D. L., Parka, R. E. and Harris, C. H.: CGRP immunoreactivity and NADPH-diaphorase in afferent nerves of the rat penis. Peptides, 13: 1239, 1992.