Distinct structural elements in GDNF mediate binding to GFRα1 and activation of the GFRα1-c-Ret receptor complex

EMBO Journal

Volumn 18, Issue 21, 1999, Pages 5901-5910

  Eketjäll, Susanna ^a   Fainzilber, Michael ^a,c   Murray Rust, Judith ^b   Ibáñez, Carlos F ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

c Ret; GDNF; GFR 1; Ligand receptor interaction; Site directed mutagenesis

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLYCOSYLPHOSPHATIDYLINOSITOL; PROTEIN TYROSINE KINASE; RECEPTOR;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; COMPLEX FORMATION; LIGAND BINDING; MOUSE; MUTANT; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING;

ANIMALS; BINDING SITES; CELL LINE; CROSS-LINKING REAGENTS; DIMERIZATION; DROSOPHILA PROTEINS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; MICE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0344423815     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.21.5901     Document Type: Article

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