The Site of Leishmania major Infection Determines Disease Severity and Immune Responses

Infection and Immunity

Volumn 71, Issue 12, 2003, Pages 6830-6834

  Baldwin, Tracey M ^a   Elso, Colleen ^a   Curtis, Joan ^a   Buckingham, Lynn ^a   Handman, Emanuela ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; EXTERNAL EAR; FEMALE; FOOT PAD; HOST PARASITE INTERACTION; IMMUNITY; INFECTION RATE; INFECTION RESISTANCE; INFECTION SENSITIVITY; LEISHMANIA MAJOR; LEISHMANIASIS; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMASTIGOTE; TAIL;

ANIMALS; EAR; FEMALE; INJECTIONS, INTRADERMAL; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; MICE; MICE, INBRED STRAINS; SEVERITY OF ILLNESS INDEX; TAIL;

EID: 0344420165     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.12.6830-6834.2003     Document Type: Article

References (25)

1. Belkaid, Y., S. Kamhawi, G. Modi, J. Valenzuela, N. Noben-Trauth, E. Rowton, J. Ribeiro, and D. L. Sacks. 1998. Development of a natural model of cutaneous Leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis. J. Exp. Med. 188:1941-1953.
2. Belkaid, Y., S. Mendez, R. Lira, N. Kadambi, G. Milon, and D. Sacks. 2000. A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity. J. Immunol. 165:969-977.
3. Biedermann, T., S. Zimmermann, H. Himmelrich, A. Gumy, O. Egeter, A. K. Sakrauski, I. Seegmuller, H. Voigt, P. Launois, A. D. Levine, H. Wagner, K. Heeg, J. A. Louis, and M. Rocken. 2001. IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice. Nat. Immunol. 2:1054-1060.
4. Bretscher, P. A., G. Wei, J. N. Menon, and H. Bielefeldt-Ohmann. 1992. Establishment of stable, cell-mediated immunity that makes " susceptible" mice resistant to Leishmania major. Science 257:539-542.
5. Chretien, S., A. Dubart, D. Beaupain, N. Raich, B. Grandchamp, J. Rosa, M. Goossens, and P. H. Romeo. 1988. Alternative transcription and splicing of the human porphobilinogen deaminase gene result either in tissue-specific or in housekeeping expression. Proc. Natl. Acad. Sci. USA 85:6-10.
6. Courret, N., E. Prina, E. Mougneau, E. M. Saraiva, D. L. Sacks, N. Glaichenhaus, and J. C. Antoine. 1999. Presentation of the Leishmania antigen LACK by infected macrophages is dependent upon the virulence of the phagocytosed parasites. Eur. J. Immunol. 29:762-773.
7. Desjeux, P., S. Mollinedo, F. Le Pont, A. Paredes, and G. Ugarte. 1987. Cutaneous leishmaniasis in Bolivia. A study of 185 human cases from Alto Beni (La Paz Department). Isolation and isoenzyme characterization of 26 strains of Leishmania braziliensis braziliensis. Trans. R. Soc. Trop. Med. Hyg. 81:742-746. (Erratum, 82:83, 1988.)
8. a. Elso, C., L. J. Roberts, G. K. Smyth, R. J. Thomson, T. M. Baldwin, S. J. Foote, and E. Handman. Leishmaniasis host response loci (Imr1, 2, and 3) modify disease severity through a Th1/Th2 independent pathway. Genes Immun., in press.
9. Greenblatt, C. L. 1980. The present and future of vaccination for cutaneous leishmaniasis. Prog. Clin. Biol. Res. 47:259-285.
10. Handman, E. 2001. Leishmaniasis: current status of vaccine development. Clin. Microbiol. Rev. 14:229-243.
11. Kebayer, C., H. Louzir, M. Chenik, A. Ben Saleh, and K. Delaggi. 2001. Heterogeneity of wild Leishmania major isolates in experimental murine pathogenicity and specific immune responses. Infect. Immun. 69:4906-4915.
12. Kirkpatrick, C. E., T. J. Nolan, and J. P. Farrell. 1987. Rate of Leishmania-induced skin-lesion development in rodents depends on the site of inoculation. Parasitology 94:451-465.
13. Locksley, R. M., F. P. Heinzel, M. D. Sadick, B. J. Holaday, and K. J. Gardner. 1987. Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets. Ann. Inst. Pasteur Immunol. 138:744-749.
14. Mitchell, G. F. 1983. Murine cutaneous leishmaniasis: resistance in reconstituted nude mice and several F1 hybrids infected with Leishmania tropica major. J. Immunogenet. 10:395-412.
15. Nabors, G. S., and J. P. Farrell. 1994. Site-specific immunity to Leishmania major in SWR mice: the site of infection influences susceptibility and expression of the antileishmanial immune response. Infect. Immun. 62:3655-3662.
16. Nicolle, C. H. 1908. Cultures des corps de Leishman isoles de la rate dans trois cas d'anemie splenique infantile. Bull. Soc. Pathol. Exot. 1:121.
17. Preston, P. M., and D. C. Dumonde. 1976. Experimental cutaneous leishmaniasis. V. Protective immunity in subclinical and selfhealing infection in the mouse. Clin. Exp. Immunol. 23:126-138.
18. Roberts, L. J., T. M. Baldwin, J. M. Curtis, E. Handman, and S. J. Foote. 1997. Resistance to Leishmania major is linked to the H2 region on chromosome 17 and to chromosome 9. J. Exp. Med. 185:1-6.
19. Sacks, D., and N. Noben-Trauth. 2002. The immunology of susceptibility and resistance to Leishmania major in mice. Nat. Rev. Immunol. 2:845-858.
20. Sacks, D. L., and R. P. da Silva. 1987. The generation of infective stage Leishmania major promastigotes is associated with the cell-surface expression and release of a developmentally regulated glycolipid. J. Immunol. 139:3099-3106.
21. Sacks, D. L., and P. V. Perkins. 1984. Identification of an infective stage of Leishmania promastigotes. Science 223:1417-1419.
22. Shaffer, J. P. 1995. Multiple hypothesis testing. Ann. Rev. Psychol. 561-576.
23. Solbach, W., and T. Laskay. 2000. The host response to Leishmania infection. Adv. Immunol. 74:275-317.
24. Titus, R. G., M. Marchand, T. Boon, and J. A. Louis. 1985. A limiting dilution assay for quantifying Leishmania major in tissues of infected mice. Parasite Immunol. 7:545-555.
25. Walton, B. C., and L. Valverde. 1979. Racial differences in espundia. Ann. Trop. Med. Parasitol. 73:23-29.