Interleukin-10 and Pathogenesis of Murine Ocular Toxoplasmosis

Infection and Immunity

Volumn 71, Issue 12, 2003, Pages 7159-7163

  Lu, Fangli ^a,b,d   Huang, Shiguang ^a,c   Kasper, Lloyd H ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; MALE; MOUSE; NECROSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; TOXOPLASMA GONDII; TOXOPLASMOSIS; TRANSGENIC MOUSE;

ANIMALS; DISEASE MODELS, ANIMAL; EYE; HUMANS; INTERLEUKIN-10; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; TOXOPLASMA; TOXOPLASMOSIS, OCULAR;

EID: 0344420100     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.12.7159-7163.2003     Document Type: Article

References (21)

1. de Waal Malefyt, R., H. Yssel, M.-G. Roncarolo, H. Spits, and J. E. de Vries. 1992. Interleukin-10. Curr. Opin. Immunol. 4:314-320.
2. el-Malky, B. S., M. Soliman, A. A. Mageid, H. E. el-Nemr, E. M. el-Nashar, and S. Hawas. 2001. IL-10 gene expression as a marker for detection of protective immunity levels with irradiated cercarial vaccine against experimental Schistosoma mansoni infection. J. Egypt. Soc. Parasitol. 31:745-760.
3. Freund, Y. R., G. Sgarlato, C. O. Jacob, Y. Suzuki, and J. S. Remington. 1992. Polymorphisms in the tumor necrosis factor alpha (TNF-α) gene correlate with murine resistance to development of toxoplasmic encephalitis and with levels of TNF-α mRNA in infected brain tissue. J. Exp. Med. 175:683-688.
4. + T cells and accompanied by overproduction of IL-12, IFN-γ, and TNF-α. J. Immunol. 157:798-805.
5. Gazzinelli, R. T., S. Hieny, T. A. Wynn, S. Wolf, and A. Sher. 1993. Interleukin-12 is required for the T-lymphocyte-independent induction of interferon-gamma by an intracellular parasite and induces resistance in T cell-deficient hosts. Proc. Natl. Acad. Sci. USA 90:3442-3447.
6. Ghalib, H. W., M. R. Piuvezam, Y. A. W. Skeiky, M. Siddig, F. A. Hashim, A. M. El-Hassan, D. M. Russo, and S. G. Reed. 1993. Interleukin-10 production correlates with pathology in human Leishmania donovani infections. J. Clin. Investig. 92:324-329.
7. + T cells. J. Immunol. 160:3188-3193.
8. + T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cells. J. Immunol. 147:2310-2316.
9. Hoffmann, K. F., S. L. James, A. W. Cheever, and T. A. Wynn. 1999. Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. J. Immunol. 163:927-938.
10. Hu, M. S., J. D. Schwartzman, A. C. Lepage, I. A. Khan, and H. L. Kasper. 1999. Experimental ocular toxoplasmosis induced in naive and preinfected mice by intracameral inoculation. Ocul. Immunol. Inflamm. 7:17-26.
11. Hunter, C. A., J. S. Abrams, M. H. Beaman, and J. S. Remington. 1993. Cytokine mRNA in the central nervous system of SCID mice infected with Toxoplasma gondii: importance of T-cell-independent regulation of resistance to T. gondii. Infect. Immun. 61:4038-4044.
12. Johnson, L. 1992. A protective role for endogenous tumor necrosis factor in Toxoplasma gondii infection. Infect. Immun. 60:1979-1983.
13. Kaufman, H. L., J. B. Rao, K. R. Irvine, V. Bronte, S. A. Rosenberg, N. P. Restifo, and K. R. Irivine. 1999. Interleukin-10 enhances the therapeutic effectiveness of a recombinant poxvirus-based vaccine in an experimental murine tumor model. J. Immunother. 22:489-496.
14. King, C. L., A. Medhat, I. Malhotra, M. Nafeh, A. Helmy, J. Khaudary, S. Ibrahim, M. El-Sherbiny, S. Zaky, R. J. Stupi, K. Brustoski, M. Shehata, and M. T. Shata. 1996. Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity. J. Immunol. 156:4715-4721.
15. Neyer, L. E., G. Grunig, M. Fort, J. S. Remington, D. Rennick, and C. A. Hunter. 1997. Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii. Infect. Immun. 65:1675-1682.
16. + cytotoxic lymphocytes. J. Virol. 74:4729-4737.
17. Schluter, D., L. Y. Kwok, S. Lutjen, S. Soltek, S. Hoffmann, H. Korner, and M. Deckert. 2003. Both lymphotoxin-alpha and TNF are crucial for control of Toxoplasma gondii in the central nervous system. J. Immunol. 170:6172-6182.
18. Silva, J. S., P. J. Morrissey, K. H. Grabstein, K. M. Mohler, D. Anderson, and S. G. Reed. 1992. Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection. J. Exp. Med. 175:169-174.
19. Suzuki, Y., M. A. Orellana, R. D. Schreiber, and J. S. Remington. 1988. Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science 240:516-518.
20. Suzuki, Y., A. Sher, G. Yap, D. Park, L. E. Neyer, O. Liesenfeld, M. Ford, H. Kang, and E. Gufwoli. 2000. IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii. J. Immunol. 164:5375-5382.
21. Wille, U., E. N. Villegas, B. Striepen, D. S. Roos, and C. A. Hunter. 2001. Interleukin-10 does not contribute to the pathogenesis of a virulent strain of Toxoplasma gondii. Parasite Immunol. 23:291-296.