Coupling of 2′-deoxyribonucleotides with 2-pyridinealdehyde methiodides

Journal of Organic Chemistry

Volumn 61, Issue 7, 1996, Pages 2561-2563

  Dodin, Guy ^a   Bourliataud, Bernadette ^a   Cordier, Christine ^a   Blais, Jean Claude ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0344418768     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9521312     Document Type: Article

References (9)

1. Dodin, G.; Kühnel, J. M.; Demerseman, P.; Kotzyba, J. Anti-Cancer Drug Des. 1993, 8, 361.
2. Only the bis-pyridinium aldehyde with a linking tether of seven methylene groups (compound 1, MW 626), as being representative of the other long chain derivatives, was considered in this study (see ref 1). For the synthesis of BPA, see the reference quoted in ref 1.
3. Huang, H.; Solomon, M. S.; Hopkins, P. B. J Am. Chem. Soc. 1992, 114, 9240.
4. Huang, H.; Hopkins, P. B. J. Am. Chem. Soc. 1993, 115, 9402.
5. The mass spectrum of the species formed from 2-OH-5′-AMP and 2 at 60°C (see ref 3) shows high proportions of the 2/1 adduct (797 Da), together with a mass corresponding to diadenosine pyrophosphate.
6. Orgel, L. E. Nature 1992, 358, 2O3.
7. Wu, T.; Orgel, L. E. J. Am. Chem. Soc. 1992, 114, 7963.
8. Ferris, J. P.; Ertem, G. J. Am. Chem. Soc. 1993, 115, 12270.
9. Prabahar, K. J.; Cole, T. D. J. Am. Chem. Soc. 1994, 116, 10914.