Inhibition of factor VIIa generation and prothrombin activation by treatment with enoxaparin in patients with unstable angina

British Journal of Haematology

Volumn 120, Issue 4, 2003, Pages 611-617

  Gerotziafas, Grigoris T ^a   Zafiropoulos, Athanasios ^b   Van Dreden, Patrick ^c   Karavaggeli, Eli ^d   Goutzoumas, Nikos ^b   Nikolaidis, Paschalis ^b   Combot, Caroline ^c   Lagoudaki, Pervez ^b   Zervas, Kostas ^a   Arzoglou, Pantelis ^e   Samama, Meyer Michel ^f  

^a THEAGENIO CANCER HOSPITAL   (Greece)

^b G GENNIMATAS GENERAL HOSPITAL   (Greece)

^c Serbio Research Laboratory   (France)

^d Agios Dimitrios General Hospital   (Greece)

^e ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^f Aristotle University of Thessaloniki ^*

Author keywords

Enoxaparin; Factor VII; TFPI; Thrombin generation; Unstable angina

Indexed keywords

ACETYLSALICYLIC ACID; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; ENOXAPARIN; GLYCERYL TRINITRATE; PROTHROMBIN; SALOSPIR; TISSUE FACTOR PATHWAY INHIBITOR;

ADULT; AGED; ARTICLE; ASSAY; BLOOD ANALYSIS; BLOOD CLOTTING; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; FEMALE; HUMAN; INHIBITION KINETICS; MALE; PRIORITY JOURNAL; UNSTABLE ANGINA PECTORIS; VALIDATION PROCESS;

AGED; AGED, 80 AND OVER; ANGINA, UNSTABLE; ANTICOAGULANTS; ENOXAPARIN; FACTOR VIIA; FACTOR XA; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; LIPOPROTEINS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; PROTHROMBIN;

EID: 0344407511     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04146.x     Document Type: Article

References (46)

1. Antman, E.M., McCabe, C.H., Gurfinkel, E.P., Turpie, A.G.G., Bernink, P.J., Salein, D., Bays de Luna, A., Fox, R., Lablanche, J.M., Radley, D., Premmereur, J. & Braunwald, E. for the TIMI 11B Investigators (1999) Enoxaparin prevents death and cardiac ishemic events in unstable angina/non-Q-wave myocardial infarction (TIMI 11b trial). Circulation, 100, 1593-1601.
2. Badimon, L. (2001) Atherosclerosis and thrombosis: lessons from animal models. Thrombosis and Haemostasis, 86, 356-365.
3. Bajaj, M.S., Birktoft, J.J., Steer, S.A. & Bajaj, S.P. (2001) Structure and biology of tissue factor pathway inhibitor. Thrombosis and Haemostasis, 86, 959-972.
4. Bara, L., Bloch, M.F., Zitoun, D., Samama, M., Collignon, F., Frydman, A., Uzan, A. & Bouthier, J. (1993) Comparative effects of enoxaparin and unfractionated heparin in healthy volunteers on prothrombin consumption in whole blood and release of tissue factor pathway inhibitor. Thrombosis Research, 69, 443-452.
5. Bauer, K.A., Kass, B.L., Ten Cate, H., Bednarek, M.A., Hawiger, J.J. & Rosenberg, R.D. (1989) Detection of factor X activation in humans. Blood, 74, 2007-2015.
6. Bendz, B., Hansen, J.B., Andersen, T.O., Ostergaard, P. & Sandset. P.M. (1999) Partial depletion of tissue factor pathway inhibitor during subcutaneous administration of unfractionated heparin, but not with two low-molecular-weight heparins. British Journal of Haematology, 107, 756-762.
7. Broze, G.J., Girard, T.J. & Novotny, W.F. (1990) Regulation of coagulation by a multivalent Kunitz-type inhibitor. Biochemistry, 29, 7539-7546.
8. Broze, G.R.J., Likert, K. & Higuchi, D. (1993) Inhibition of factor VIIa/tissue factor by antithrombin III and tissue factor pathway inhibitor. Blood, 82, 1679-1680.
9. Cohen, M., Demers, C., Gurfinkel, E.P., Turpie, A.G.G., Fromell, G.J., Goodman, S., Langer, A., Califf, R.M., Fox, K.A.A., Premmereur, J. & Bigonzi, F. for the Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-wave Coronary Events Study Group. (1997) A comparison of low molecular weight heparin with unfractionated heparin for unstable coronary artery disease. New England Journal of Medicine, 337, 442-452.
10. Depasse, F., Heilmann. J.J., Busson. J., Clonier, F. & Samama, M.M. (2002) Free TFPI and factor VII profiles after multiple subcutaneous doses of 175 anti-Xa IU/kg per day of tinzaparin (Innohep) in healthy volunteers. Pathophysiology of Haemostasis and Thrombosis, 32, 153.
11. Eichinger, S., Mannucci, P.M., Tradati, F., Arbini, A.A. & Rosenberg, R.D. (1995) Determinants of plasma factor VIIa levels in humans. Blood, 86, 3021-3025.
12. Eriksson, B.L., Soserberg, K., Wislund, L., Wandeli, B., Tengborn, L. & Risberg, B. (1995) A comparative study of three low molecular weight heparins (LMWH) and unfractionated heparin (UFH) in healthy volunteers. Thrombosis and Haemostasis, 73, 398-401.
13. Frydman, A.M., Bara, L., Le Roux, Y., Woler, M., Chauliac, F. & Samama, M.M. (1988) The antithrombotic activity and pharmacokinetics of enoxaparin, a low molecular weight heparin in humans given single subcutaneous doses of 20-80 mg. Journal of Clinical Pharmacology, 28, 609-618.
14. Gemmell, C.H., Turitto, V.T. & Nemerson, Y. (1991) Factors affecting the interaction of tissue factor/factor VII with factor X in a heterogeneous tubular reactor. Thrombosis and Haemostasis, 65, 139-143.
15. Gerotziafas, G.T. (1999) Génération du FVIIa pendant la coagulation du plasma humain. Etude du mécanisme d'inhibition de la génération et de l'activité du FVIIa induite par le pentasaccharide synthétique, l'héparine de bas poids moléculaire et l'héparine non fractionnée. Comparaison avec l'hirudine recombinante. Doctoral Thesis. Université Paris VI. France.
16. Gerotziafas, G.T., Bara, L., Bloch, M.F., Makris, P.E. & Samama, M.M. (1996) Treatment with LMWHS inhibits factor VIIa generation during in vitro coagulation of whole blood. Thrombosis Research, 81, 491-496.
17. Gerotziafas, G.T., Bara, L., Bloch, M.F., Makris, P.E. & Samama, M.M. (1998) Comparative effects of the synthetic pentasaccharide, low molecular weight heparin, unfractionated heparin and recombinant hirudin on factor VIIa generation and prothrombin activation after coagulation of human plasma. Blood Coagulation and Fibrinolysis, 9, 571-580.
18. Giannitsis, E., Bardorff, M.M., Schweikart, S., Wiegand, U., Kampmann, M. & Katus, H.A. (2000) Relationship of cardiac troponin T and procoagulant activity in unstable angina. Thrombosis and Haemostasis, 83, 224-228.
19. Giesen, P.L.A., Rauch, U., Bohrmann, B., Kling, D., Roqué M., Fallon, J.T., Badimon, J.J., Himber, J., Riederer, M.A. & Nemerson, Y. (1999) Blood-borne tissue factor: another view of thrombosis. Proceedings of National Academy of Sciences of the United States of America, 96, 2311-2315.
20. Hansen, J.B., Sandset, P.M., Huseby, K.R., Huseby, N.E. & Nordøy, A. (1996) Depletion of intravascular pools of tissue factor pathway inhibitor (TFPI) during repeated or continuous intravenous infusion of heparin in man. Thrombosis and Haemostasis, 76, 703-709.
21. Hansen, J.B., Sandset, P.M., Huseby, K.R., Huseby, N.E., Bendz, B., Ostergaard, P. & Nordoy, A. (1998) Differential effect of unfractionated heparin and low molecular weight heparin on intravascular tissue factor pathway inhibitor: evidence for a difference in antithrombotic action. British Journal of Haematology, 101, 638-646.
22. Hansen, J.B., Svenson, B., Sandset, P.M. & Thijssen, F. (2000) Reduction of factor VIIa activity during heparin therapy evidence for assay interactions with tissue factor pathway inhibitor and antithrombin. Thrombosis Research, 100, 389-396.
23. Hemker, H.C. & Béguin, S. (1993) Mode of action of low-molecular-weight heparins in plasma and its consequences for the clinical laboratory. In: Low-Molecalar-Weight Heparins in Prophylaxis and Therapy of Thromboembolic Diseases (ed. by H. Bounameaux), pp. 21-42. Marcel Dekker, New York.
24. Hubbard, A.R. & Barrowcliffe, T.W. (1994) Measurement of activity factor VII using soluble mutant tissue factor proposal for standardisation. Thrombosis and Haemostasis, 72, 644-650.
25. Jesty, J., Lorenz, A., Rodriguez, J. & Wun, T.C. (1996) Initiation of the tissue factor pathway coagulation in the presence of heparin: control by antithrombin III and tissue factor pathway inhibitor. Blood, 87, 2301-2307.
26. Jin, J., Abrahams, J.P., Skinner, R., Petitou, M., Pike, R.N. & Carrel, R.W. (1997) The anticoagulant activation of antithrombin by heparin. Proceedings of National Academy of Sciences of the United States of America, 94, 14683-14688.
27. Josso, F. & Beguin, S. (1969) The possible role of factor VII in the intrinsic system. In: Human Blood Coagulation. Biochemistry, Clinical Investigation and Therapy (ed. by H.C. Hemker. E.A. Loeliger & J.J. Veltkampm), pp. 77-82. Leiden University Press, Leiden.
28. Kalafatis, M., Egan. J., van't Veer, C., Cawthern, K.M. & Mann, K.G. (1997) The regulation of clotting factors. Critical Reviews in Eukariotique Gene Expression, 7, 241-280.
29. Kondo, S. & Kisiel, W. (1987) Regulation of factor VIIa activity in plasma: evidence that antithrombin III is the sole plasma protease inhibitor of human factor VIIa. Thrombosis Research, 46, 325-335.
30. Lormeau, J.C., Herault, J.P. & Herbert, J.M. (1996) Antithrombin-mediated inhibition of factor VIIa-tissue factor complex by the synthetic pentasaccharide representing the heparin binding site to antithrombin. Thrombosis and Haemostasis, 76, 5-8.
31. Morrissey, J.H. (2001) Tissue factor: an enzyme cofactor and a true receptor. Thrombosis and Haemostasis, 86, 66-74.
32. Morrissey, J.H., Macik, B.G., Neuenschwander, P.F. & Comp, P.C. (1993) Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation. Blood, 81, 734-744.
33. Nemerson, Y. & Contino, P.B. (1996) Tissue factor, flow and the initiation of coagulation. In: Hypercoagulable States. Fundamental Aspects, Acquired Disorders and Congenital Thrombophilia (ed. by M.J. Seghatchian, M.M. Samama & S.P. Hecker), pp. 21-28. CRC Press. Boca Raton.
34. Ostergaard, P.B., Beck, T.C., Orsted, H., Svendsen, A., Nordfang, O., Sandset, P.M. & Hansen, J.B. (1997) An enzyme linked immunosorbtion assay for tissue factor pathway inhibitor. Thrombosis Research, 87, 447-459.
35. Østerud, B. & Rapaport, S.I. (1977) Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation. Proceedings of National Academy of Sciences of the United States of America, 74, 5260-5264.
36. Pernerstorfer, T., Jilma, B., Eichler, H.G., Aull, S., Handler, S. & Speiser, W. (1999) Heparin lowers plasma levels of activated factor VII. British Journal of Hematology, 105, 1127-1129.
37. Philippou, H., Adami, A., Amersey, R.A., Stubbs, P.J. & Lane, D.A. (1997) A novel specific immunoassay for plasma two-chain factor VIIa: investigation of FVIIa levels in normal individuals and in patients with acute coronary syndromes. Blood, 89, 767-775.
38. Rao, L.V.M. & Rapaport, S.I. (1988) Activation of factor VII bound to tissue factor: a key step in the tissue factor pathway of blood coagulation. Proceedings of National Academy of Sciences of the United States of America, 85, 6686-6691.
39. Rao, L.V.M., Rapaport, S.I. & Hoang, A.D. (1993) Binding of factor VIIa to tissue factor permits rapid antithrombin III/heparin inhibition of factor VIIa. Blood, 81, 2600-2607.
40. Salvioni, A., Casilli, F., Assanelli, E., Grazi, M., Marenzi, G. & Guazzi, M.D. (2001) Comparison of enoxaparin and unfractionated heparin on thrombin generation in acute coronary syndromes without ST-segment elevation. Thrombosis and Haemostasis, 86, 991-994.
41. Samama, M.M., Bara, L. & Gerotziafas, G.T. (1994) Mechanisms for the antithrombotic activity in man of low molecular weight heparins (LMWHs). Haemostasis, 24, 105-117.
42. Samama, M.M. & Gerotziafas, G.T. (2000) Comparative pharmacokinetics of LMWHs. Seminars in Thrombosis and Hemostasis, 26, 31-38.
43. Sandset, P.M., Abildgaard, U. & Larsen, M.L. (1988) Heparin induces release of extrinsic coagulation pathway inhibitor (EPI). Thrombosis Research, 50, 803-813.
44. Seligsohn, U., Østerud, B., Brown, S.F. & Griffin, J.H. (1979) Activation of human factor VII in plasma and in purified systems. Journal of Clinical Investigation, 64, 1056-1065.
45. Vuillemenot, A., Schiele, F., Meneveau, N., Claudel, S., Donat, F., Fontecave, S., Cariou, R., Samama, M.M. & Bassand, J.P. (1999) Efficacy of a synthetic pentasaccharide, a pure factor Xa inhibitor, as an antithrombotic agent: a pilot study in the setting of coronary angioplasty. Thrombosis and Haemostasis, 81, 214-220.
46. Wildgoose, P., Nemerson, Y., Hansen, L.L., Nielsen, F.E., Glazer, S. & Hedner, U. (1992) Measurement of basal levels of factor VIIa in hemophilia A and B patients. Blood, 80, 25-28.