Possible involvement of IGF-1 receptor and IGF-binding protein in insulin-induced enhancement of noradrenaline response in diabetic rat aorta

Folia Pharmacologica Japonica

Volumn 122, Issue SUPPL. 1, 2003, Pages

  Kobayashi, Tsuneo ^a   Matsumoto, Takayuki ^a   Kamata, Katsuo ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Diabetes; Insulin; Insulin like growth factor; Vascular endothelial cells; Vascular smooth muscle cells

Indexed keywords

GROWTH FACTOR; INSULIN; ISOPROTEIN; NORADRENALIN; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN RECEPTOR; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; BLOOD VESSEL; HYPERINSULINEMIA; MUSCLE CONTRACTILITY; NONHUMAN; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES;

ANIMALS; AORTA; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIUM, VASCULAR; EPINEPHRINE; INSULIN; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; MALE; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, WISTAR; RECEPTOR, IGF TYPE 1; VASOCONSTRICTION;

EID: 0344394292     PISSN: 00155691     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Kobayashi T, Kamata K. Effect of insulin treatment on the smooth muscle contractility and endothelium-dependent relaxation in rat aortae from established STZ-induced diabetes. Br J Pharmacol. 1999; 127:835-842.
2. Kobayashi T, Kamata K. Effect of chronic insulin treatment on NO metabolism and endothelium-dependent relaxation in rats aortae from established STZ-induced diabetic rats. Atherosclerosis. 2001; 155:313-320.
3. Kobayashi T, Kamata K. Short-term insulin treatment and aortic expressions of IGF-1 receptor and VEGF mRNA in diabetic rats. Am J Physiol Heart Circ Physiol. 2002; 283:H1761-1768.
4. Kobayashi T, Kaneda K, Kamata K. Possible involvement of IGF-1 receptor and IGF-binding protein in insulin-induced enhancement of noradrenaline response in diabetic rat aorta. Br J Pharmacol. (in press).