Molecular mechanisms for cAMP-independent activation of MaxiK channel: G protein direct channel regulation and contribution to the tuning of vascular smooth muscle tone

Folia Pharmacologica Japonica

Volumn 122, Issue SUPPL. 1, 2003, Pages

  Yamaki, Fumiko ^a   Tanaka, Yoshio ^a   Horinouchi, Takahiro ^a   Shigenobu, Koki ^a   Koike, Katsuo ^a  

^a TOHO UNIVERSITY   (Japan)

Author keywords

cAMP; G protein; IP receptor; MaxiK channel; Vascular smooth muscle

Indexed keywords

4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; 9 (TETRAHYDRO 2 FURYL)ADENINE; ADENYLATE CYCLASE; BERAPROST; CHOLERA TOXIN; CYCLIC AMP; GUANOSINE TRIPHOSPHATE; IBERIOTOXIN; PHOSPHODIESTERASE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PROSTACYCLIN RECEPTOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; GUINEA PIG; MOLECULAR DYNAMICS; MUSCLE CELL; NONHUMAN; PROTEIN FUNCTION; QUALITATIVE ANALYSIS; THORACIC AORTA; VASODILATATION;

ANIMALS; CYCLIC AMP; GTP-BINDING PROTEINS; GUINEA PIGS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MUSCLE, SMOOTH, VASCULAR; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RECEPTORS, EPOPROSTENOL; VASODILATION;

EID: 0344394290     PISSN: 00155691     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Ca, a unique member of the voltage-gated K channel superfamily. News Physiol Sci. 1998;13:112-117.
2. 2+ channels. Gen Pharmacol. 2000;34:159-165.
3. + channel, Hslo, is a target of cGMP-dependent protein kinase phosphorylation in vivo. J Biol Chem. 1998;273:32950-32956.
4. Ca channel in smooth muscle. Trends Pharmacol Sci. 2001;22:505-512.
5. 2+ levels and muscle contraction in isolated guinea pig aorta. Jpn J Pharmacol. 1996;71:231-237.
6. Turcato S, Clapp LH. Effects of the adenylyl cyclase inhibitor SQ22,536 on iloprost-induced vasorelaxation and cyclic AMP elevation in isolated guinea-pig aorta. Br J Pharmacol. 1999;126:845-847.
7. Narumiya S, Sugimoto Y, Ushikubi F. Prostanoid receptors: structures, properties, and function. Physiol Rev. 1999;79:1193-1226.
8. Corriu C, Félétou, M. M, Edwards G, Weston AH, Vanhoutte PM. Differential effects of prostacyclin and iloprost in the isolated carotid artery of the guinea-pig. Eur J Pharmacol. 2001;426:89-94.
9. Ca-channel activation by cAMP-dependent protein kinase. Am J Physiol. 1997;272:147-156.
10. + channels play a major role in mediating the vascular effects of iloprost and cicaprost. Eur J Pharmacol. 1998;356:215-224.
11. Yamaki F, Kaga M, Horinouchi T, Tanaka H, Koike K, Shigenobu K, Toro L, Tanaka Y. MaxiK channel-mediated relaxation of guinea-pig aorta following stimulation of IP receptor with beraprost via cyclic AMP-dependent and -independent mechanisms. Naunyn Schmiedeberg's Arch Pharmacol. 2001;364:538-550.