Possible Relationship between Testosterone and Comorbid Major Depressive Episode in Male Patients with Schizophrenia Treated with Typical Antipsychotic Medications

Clinical Neuropharmacology

Volumn 26, Issue 6, 2003, Pages 291-293

  Kaneda, Yasuhiro ^a,b  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b Psychiatric Hospital at Vanderbilt   (United States)

Author keywords

Antipsychotic agents; Depression; Schizophrenia; Testosterone

Indexed keywords

NEUROLEPTIC AGENT; PROLACTIN; TESTOSTERONE;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; COMORBIDITY; DEPRESSION; DRUG MEGADOSE; HUMAN; HYPOGONADISM; MAJOR DEPRESSION; MALE; MENTAL DISEASE; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; RADIOIMMUNOASSAY; SCHIZOPHRENIA; TESTOSTERONE BLOOD LEVEL; TREATMENT OUTCOME;

ADULT; ANTIPSYCHOTIC AGENTS; DEPRESSIVE DISORDER, MAJOR; HUMANS; MALE; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TESTOSTERONE;

EID: 0344306579     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002826-200311000-00005     Document Type: Article

References (27)

1. Coryell W, Zimmerman M. Diagnosis and outcome in schizoaffective depression: a replication. J Affect Disord. 1988;15:21-27.
2. Siris SG. Depression in schizophrenia: perspective in the era of 'Atypical' antipsychotic agents. Am J Psychiatry. 2000;157:1379-1389.
3. Seidman SN, Walsh BT. Testosterone and depression in aging men. Am J Geriatr Psychiatry. 1999;7:18-33.
4. Sternbach H. Age-associated testosterone decline in men: clinical issues for psychiatry. Am J Psychiatry. 1998;155:1310-1318.
5. Bressan RA, Costa DC, Jones HM, et al. Typical antipsychotic drugs-D(2) receptor occupancy and depressive symptoms in schizophrenia. Schizophr Res. 2002;56:31-36.
6. Kapur S, Mann JJ. Role of the dopaminergic system in depression. Biol Psychiatry. 1992;32:1-17.
7. Brown WA, Laughren TP, Williams B. Differential effects of neuroleptic agents on the pituitary-gonadal axis in men. Arch Gen Psychiatry. 1981;38:1270-1272.
8. Brambilla F, Guerrini A, Guastalla A, et al. Neuroendocrine effects of haloperidol therapy in chronic schizophrenia. Psychopharmacologia. 1975;44:17-22.
9. Kaneda Y, Fujii A. Effects of chronic neuroleptic administration on the hypothalamo-pituitary-gonadal axis of male schizophrenics. Prog Neuropsychopharmacol Biol Psychiatry. 2000;24:251-258.
10. Kaneda Y. Depressive symptoms in chronic schizophrenia patients: any differences between patients with and without a major depressive episode? Eur Psychiatry. 2003;18:137-139.
11. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fourth Edition (DSM-IV). Washington, D.C.: American Psychiatric Association, 1994.
12. Kaneda Y, Ohmori T, Addington D. The Japanese version of the Calgary Depression Scale for Schizophrenics (JCDSS) (in Japanese). No To Shinkei. 2000;52:163-166.
13. Addington D, Addington J, Schissel B. A depression rating scale for schizophrenics. Schizophr Res. 1990;3:247-251.
14. Overall JE, Gorham DR. The brief psychiatric rating scale. Psychol Rep. 1962;10:799-812.
15. Inada T. Evaluation and Diagnosis of Drug-Induced Extrapyramidal Symptoms: Commentary on the DIEPSS and guide to its usage (in Japanese). Tokyo: Seiwa Pub., 1996.
16. Kulhara P, Avasthi A, Chadda R, et al. Negative and depressive symptoms in schizophrenia. Br J Psychiatry. 1989;154:207-211.
17. Lindenmayer JP, Kay SR, Plutchik R. Multivantaged assessment of depression in schizophrenia. Psychiatry Res. 1992;42:199-207.
18. Barnes TR, Curson DA, Liddle PF, et al. The nature and prevalence of depression in chronic schizophrenic in-patients. Br J Psychiatry. 1989;154:486-491.
19. Kaneda Y, Fujii A, Okura M, et al. Depressive Symptoms in Medicated Chronic Schizophrenics. German J Psychiatry. 1999;2:1-12.
20. Zisook S, McAdams LA, Kuck J, et al. Depressive symptoms in schizophrenia. Am J Psychiatry. 1999;156:1736-1743.
21. Knights A, Hirsch SR. Revealed Depression and drug treatment for schizophrenia. Arch Gen Psychiatry. 1981;38:806-811.
22. Galdi J. The causality of depression in schizophrenia. Br J Psychiatry. 1983;142:621-624.
23. Rupprecht R, Rupprecht C, Rupprecht M, et al. Different reactivity of the hypothalamo-pituitary-gonadal-axis in depression and normal controls. Pharmacopsychiatry. 1988;21:438-439.
24. Undén F, Ljunggren JG, Beck-Friis J, et al. Hypothalamic-pituitary-gonadal axis in major depressive disorders. Acta Psychiatr Scand. 1988;78:138-146.
25. Vogel W, Klaiber EL, Broverman DM. Roles of the gonadal steroid hormones in psychiatric depression in men and women. Prog Neuropsychopharmacol. 1978;2:487-503.
26. Yesavage JA, Davidson J, Widrow L, et al. Plasma testosterone levels, depression, sexuality, and age. Biol Psychiatry. 1985;20:222-225.
27. Hamner M. The effects of atypical antipsychotics on serum prolactin levels. Ann Clin Psychiatry. 2002;14:163-173.